CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID287
Family Name Corticotropin-releasing factor receptor 1 Ligand Dmp-695/696 Family
No. of Seeds 11 No. of Other Members 20
Family Centroid CFAMM00186427 Functional Category Investigative Drug
Superfamily Corticotropin-releasing factor receptor 1 Ligand Dmp-695/696 Superfamily
Class Class 37

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
PF-4217903 family 14 65
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... 4 12
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 17
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YT9... 28 20
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
Adenosine receptor A3 and Adenosine receptor A2a ligand SureCN... 8 7
G1/S-specific cyclin-E1 and Cyclin-dependent kinase 2 inhibito... 1 5
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Tyrosine-protein kinase JAK2 inhibitor N-[2-(3-chlorophenyl)-5... 2 11
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Prostaglandin D2 receptor ligand N-[2-(2,4-dichlorophenyl)ethy... 2 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 5-[4-... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 9 6
Neuropeptide Y receptor type 1 ligand CP-671906 family 10 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Corticotropin-releasing factor receptor 1 ligand 5-(2,4-dichlo... 5 17
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Dipeptidyl peptidase 4 inhibitor Aminomethylpyrimidine 1ck family 6 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threon... 2 1
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-[8-... 2 5
Cyclin-dependent kinase 2 and MAP kinase-activated protein kin... 3 0
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 5 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 1 0
Cytochrome P450 3A4 and Cytochrome P450 2C8 inhibitor N-[3-[(1... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-met... 2 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3,5-b... 4 6
Corticotropin-releasing factor receptor 1 ligand AGN-PC-01Z2AT... 1 10
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 1
Corticotropin-releasing factor receptor 1 ligand 4-[7-(dipropy... 1 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 0
Adenosine receptor A1 ligand 3-[(2-chlorophenyl)methyl]-N-cycl... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 1 0
Corticotropin-releasing factor receptor 1 ligand 8-(4-bromo-2-... 1 0
Activated CDC42 kinase 1 inhibitor AGN-PC-078WDN family 7 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CCI... 3 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 17 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 1 1
Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family 9 14
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
Potassium voltage-gated channel subfamily A member 5 ligand (7... 5 18


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00186433 CHEMBL138155 Bioactive 8-(2,4-dichlorophenyl)-N-(1-methoxybutan-2-yl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine
CFAMM00186431 CHEMBL1771258 Bioactive SureCN7044646
CFAMM00186429 CHEMBL336678 Bioactive 8-(2,4-dichlorophenyl)-2,7-dimethyl-N-pentan-3-ylpyrazolo[1,5-a][1,3,5]triazin-4-amine
CFAMM00186415 CHEMBL141692 Bioactive 8-(2,4-dichlorophenyl)-N-(1,3-diethoxypropan-2-yl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine
CFAMM00186436 CHEMBL141084 Bioactive 8-(2,4-dichlorophenyl)-N,N-bis(2-methoxyethyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine
CFAMM00186435 CHEMBL141085 Bioactive 8-(2,4-dichlorophenyl)-N-heptan-3-yl-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine
CFAMM00186450 CHEMBL2165205 Bioactive [11C]DMP-696
CFAMM00186426 CHEMBL140143 Bioactive 8-(2,4-dichlorophenyl)-N-hexan-3-yl-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine
CFAMM00186434 CHEMBL138154 Bioactive 8-(2,4-dichlorophenyl)-N-heptan-4-yl-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine
CFAMM00186456 DNC003911 Investigative Drug DMP-696
CFAMM00186427 DNC000571 Investigative Drug DMP-695/696

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24631 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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