CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2887
Family Name Renin Inhibitor Zankiren Family
No. of Seeds 32 No. of Other Members 50
Family Centroid CFAMM00279075 Functional Category Investigative Drug
Superfamily HIV protease Inhibitor Ritonavir Superfamily
Class Class 135

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Ritonavir Family 12 49
Tubulin beta chain Inhibitor DOLASTATIN-10 Family 4 93
Coagulation factor X Inhibitor Phso2-gly-(me-gly)-arg-(2-thiaz... 32 62
Pol polyprotein inhibitor AC1LAD48 family 19 5
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 1 1
Cationic trypsin and Prothrombin inhibitor benzyl N-[(2R)-1-[(... 2 6
Renin inhibitor (1R,2R,3R)-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl... 3 0
Pol polyprotein inhibitor (2S)-N-[(2S,3S,4S,5S)-5-[[(2R)-2-[[(... 2 1
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 1 0
Renin and Pepsin A inhibitor [(2S)-1-[[(2R)-1-[[(2S,3S)-1-cycl... 1 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00279091 CHEMBL49862 Bioactive (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-4-morpholin-4-yl-4-oxobutanamide
CFAMM00279044 CHEMBL142942 Bioactive (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-N'-methyl-N'-(2-morpholin-4-ylethyl)butanediamide
CFAMM00279071 CHEMBL316218 Bioactive (3S,4S)-4-[[(2S)-3-(2-amino-1,3-thiazol-4-yl)-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]propanoyl]amino]-N-[2-[bis(2-hydroxyethyl)amino]ethyl]-5-cyclohexyl-3-hydroxypentanamide
CFAMM00279084 CHEMBL297429 Bioactive 2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-3-phenylpropanamide
CFAMM00279037 CHEMBL264848 Bioactive (1S,2R,3S)-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-2-(2-morpholin-4-yl-2-oxoethyl)-3-phenylcyclopropane-1-carboxamide
CFAMM00279097 CHEMBL296051 Bioactive (2R,3S)-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-2,3-diphenylcyclopropane-1-carboxamide
CFAMM00279064 CHEMBL30375 Bioactive (1S,2R,3S)-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-2-methylsulfonyl-3-phenylcyclopropane-1-carboxamide
CFAMM00279077 CHEMBL313063 Bioactive (2S)-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanamide
CFAMM00279090 CHEMBL30620 Bioactive (1S,2S,3R)-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-2-phenyl-3-propan-2-ylsulfonylcyclopropane-1-carboxamide
CFAMM00279057 CHEMBL281508 Bioactive (2S)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-3-morpholin-4-ylsulfonylpropanamide
CFAMM00279103 CHEMBL46607 Bioactive (1R,2R,3R)-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-2-(morpholine-4-carbonyl)-3-phenylcyclopropane-1-carboxamide
CFAMM00279083 CHEMBL344465 Bioactive (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-N'-(2-methoxyethyl)-N'-methylbutanediamide
CFAMM00279036 CHEMBL88091 Bioactive (2S)-N-[(2S)-3-(2-amino-1,3-thiazol-4-yl)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxopropan-2-yl]-3-phenyl-2-(piperazin-1-ylsulfonylamino)propanamide
CFAMM00279049 CHEMBL140731 Bioactive (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-N'-[3-(dimethylamino)propyl]-N'-methylbutanediamide
CFAMM00279042 CHEMBL30869 Bioactive (1S,2R,3S)-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-2-ethenylsulfonyl-3-phenylcyclopropane-1-carboxamide
CFAMM00279035 CHEMBL358152 Bioactive (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-N'-methyl-N'-[2-(4-methylpiperazin-1-yl)ethyl]butanediamide
CFAMM00279062 CHEMBL281487 Bioactive (1R,2S,3R)-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-2-ethenylsulfonyl-3-phenylcyclopropane-1-carboxamide
CFAMM00279027 CHEMBL88069 Bioactive (2S)-N-[(2S)-3-(2-amino-1,3-thiazol-4-yl)-1-[[(2S,3S,5S)-1-cyclohexyl-3,5-dihydroxyheptan-2-yl]amino]-1-oxopropan-2-yl]-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanamide
CFAMM00279020 CHEMBL344272 Bioactive (2R)-2-benzyl-N-[(2S)-1-[[(1R,2S)-3-cyclohexyl-1-[(5S)-3-ethyl-2-oxo-1,3-oxazolidin-5-yl]-1-hydroxypropan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-4-morpholin-4-yl-4-oxobutanamide
CFAMM00279047 CHEMBL342711 Bioactive (2S)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-3-(1-methylpiperidin-4-yl)sulfonylpropanamide
CFAMM00279061 CHEMBL30968 Bioactive 2-(benzenesulfonylmethyl)-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3-hydroxy-4-methoxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-3-phenylpropanamide
CFAMM00279054 CHEMBL279780 Bioactive (2S)-2-benzyl-3-tert-butylsulfonyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]propanamide
CFAMM00279067 CHEMBL280977 Bioactive (1R,2R,3S)-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-2-phenyl-3-propan-2-ylsulfonylcyclopropane-1-carboxamide
CFAMM00279080 CHEMBL332228 Bioactive ACMC-20mvv4
CFAMM00279093 CHEMBL49460 Bioactive (1S,2S,3S)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-3-(morpholine-4-carbonyl)cyclopropane-1-carboxamide
CFAMM00279025 CHEMBL341531 Bioactive AGN-PC-0753NF
CFAMM00279079 CHEMBL87389 Bioactive (2S)-4-(2-amino-1,3-thiazol-4-yl)-N-[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]butanamide
CFAMM00279092 CHEMBL141948 Bioactive (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-N'-[2-(dimethylamino)ethyl]-N'-methylbutanediamide
CFAMM00279085 CHEMBL140436 Bioactive (2S)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]-3-(1-methylazetidin-3-yl)sulfonylpropanamide
CFAMM00279024 CHEMBL314066 Bioactive (2S)-N-[1-(2-amino-1,3-thiazol-4-yl)-2-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-2-oxoethyl]-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanamide
CFAMM00279075 DNC009742 Investigative Drug ZANKIREN
CFAMM00279041 DNC012404 Investigative Drug CI-992

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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