CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2891
Family Name B2 bradykinin receptor Ligand FR-173657 Family
No. of Seeds 44 No. of Other Members 180
Family Centroid CFAMM00279283 Functional Category Investigative Drug
Superfamily B2 bradykinin receptor Ligand FR-173657 Superfamily
Class Class 2014

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
B2 bradykinin receptor Ligand Anatibant Family 49 15
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
B2 bradykinin receptor ligand SureCN6578325 family 2 1
B2 bradykinin receptor ligand 2-(4-aminobutylcarbamoylamino)-N... 5 0
B2 bradykinin receptor ligand (E)-3-(6-acetamidopyridin-3-yl)-... 1 0
Vascular endothelial growth factor receptor 2 and Fibroblast g... 10 3
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
B2 bradykinin receptor ligand SureCN8561638 family 30 3
B2 bradykinin receptor ligand SureCN7749611 family 4 1
B2 bradykinin receptor ligand 4-[(E)-3-[[2-[2,4-dichloro-3-[[4... 29 2
B2 bradykinin receptor ligand SureCN7977402 family 5 6
B2 bradykinin receptor ligand (E)-3-[6-(2-oxopyrrolidin-1-yl)p... 3 2
B2 bradykinin receptor ligand SureCN8516699 family 3 2
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Neuropeptide Y receptor type 1 ligand 2-[(4-chlorophenoxy)meth... 5 13
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QHF0 family 3 1
Somatostatin receptor type 2 ligand SureCN4325675 family 3 1
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Melanin-concentrating hormone receptor 1 ligand N-[3-(2-aminoq... 4 1
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(2,6-di... 14 8
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... 3 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 5 0
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
B2 bradykinin receptor ligand AGN-PC-073GJI family 2 4
B2 bradykinin receptor ligand SureCN7976932 family 2 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Coagulation factor X inhibitor 3-Oxybenzamide 48 family 1 12
B2 bradykinin receptor ligand (E)-N-[2-[N-methyl-3-[(2-methylq... 2 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 4 3
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
B2 bradykinin receptor ligand 4-[(E)-3-[[1-[2,4-dichloro-3-[(4... 3 0
Sterol O-acyltransferase 1 inhibitor AGN-PC-07CO2O family 1 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 1 0
Neuropeptide Y receptor type 1 ligand [1-(4-chlorophenoxy)-9-[... 5 7


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00279177 CHEMBL264751 Bioactive SureCN7978830
CFAMM00279238 CHEMBL98460 Bioactive N-[4-[(E)-3-[[2-[2,4-dichloro-N-methyl-3-[[2-methyl-4-(pyridin-2-ylmethoxy)quinolin-8-yl]oxymethyl]anilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]phenyl]pyridine-4-carboxamide
CFAMM00279303 CHEMBL544480 Bioactive 4-[(E)-3-[[2-[2,4-dichloro-3-[(4-imidazol-1-yl-2-methylquinolin-8-yl)oxymethyl]-N-methylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-pyridin-4-ylbenzamide;hydrochloride
CFAMM00279223 CHEMBL328131 Bioactive SureCN6644131
CFAMM00279296 CHEMBL540819 Bioactive 4-[(E)-3-[[2-[2,4-dichloro-N-methyl-3-[(2-methylquinolin-8-yl)oxymethyl]anilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-pyridin-3-ylbenzamide;dihydrochloride
CFAMM00279163 CHEMBL98349 Bioactive SureCN6955167
CFAMM00279189 CHEMBL329701 Bioactive SureCN6970102
CFAMM00279348 CHEMBL539792 Bioactive N-[4-[(E)-3-[[2-[2,4-dichloro-N-methyl-3-[(2-methyl-4-piperidin-1-ylquinolin-8-yl)oxymethyl]anilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]phenyl]pyridine-4-carboxamide;hydrochloride
CFAMM00279328 CHEMBL542177 Bioactive AGN-PC-07BZFG
CFAMM00279282 CHEMBL539023 Bioactive 4-[(E)-3-[[2-[2,4-dichloro-3-[[4-(dimethylamino)-2-methylquinolin-8-yl]oxymethyl]-N-methylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-(pyridin-2-ylmethyl)benzamide;hydrochloride
CFAMM00279354 CHEMBL98292 Bioactive SureCN8011552
CFAMM00279162 CHEMBL540840 Bioactive SureCN8562998
CFAMM00279209 CHEMBL544601 Bioactive SureCN7748220
CFAMM00279262 CHEMBL542598 Bioactive AGN-PC-07BYP9
CFAMM00279321 CHEMBL555202 Bioactive N-[5-[(E)-3-[[2-[2,4-dichloro-N-methyl-3-[(2-methylquinolin-8-yl)oxymethyl]anilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]pyridin-2-yl]pyridine-4-carboxamide;trihydrochloride
CFAMM00279242 CHEMBL539294 Bioactive 4-[(E)-3-[[2-[2,4-dichloro-N-methyl-3-[(2-methylquinolin-8-yl)oxymethyl]anilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-pyridin-4-ylbenzamide;dihydrochloride
CFAMM00279373 CHEMBL544549 Bioactive 4-[(E)-3-[[2-[2,4-dichloro-3-[[4-(dimethylamino)-2-methylquinolin-8-yl]oxymethyl]-N-methylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-pyridin-4-ylbenzamide;hydrochloride
CFAMM00279353 CHEMBL430652 Bioactive 5-[(E)-3-[[2-[2,4-dichloro-N-methyl-3-[[2-methyl-4-(pyridin-2-ylmethoxy)quinolin-8-yl]oxymethyl]anilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-[(E)-2-pyridin-4-ylethenyl]pyridine-2-carboxamide
CFAMM00279281 CHEMBL554881 Bioactive 4-[(E)-3-[[2-[2,4-dichloro-3-[(4-imidazol-1-yl-2-methylquinolin-8-yl)oxymethyl]-N-methylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide;hydrochloride
CFAMM00279327 CHEMBL542176 Bioactive 5-[(E)-3-[[2-[2,4-dichloro-N-methyl-3-[(2-methyl-4-morpholin-4-ylquinolin-8-yl)oxymethyl]anilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylpyridine-2-carboxamide;hydrochloride
CFAMM00279366 CHEMBL545021 Bioactive N-[4-[(E)-3-[[2-[2,4-dichloro-N-methyl-3-[(2-methyl-4-morpholin-4-ylquinolin-8-yl)oxymethyl]anilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]phenyl]pyridine-4-carboxamide;hydrochloride
CFAMM00279346 CHEMBL329762 Bioactive SureCN8011090
CFAMM00279280 CHEMBL98458 Bioactive SureCN6964858
CFAMM00279365 CHEMBL555853 Bioactive 4-[(E)-3-[[2-[2,4-dichloro-3-[(4-imidazol-1-yl-2-methylquinolin-8-yl)oxymethyl]-N-methylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N,N-dimethylbenzamide;hydrochloride
CFAMM00279332 CHEMBL544087 Bioactive 5-[(E)-3-[[2-[2,4-dichloro-3-[[4-(dimethylamino)-2-methylquinolin-8-yl]oxymethyl]-N-methylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylpyridine-2-carboxamide;hydrochloride
CFAMM00279173 CHEMBL542958 Bioactive SureCN7746556
CFAMM00279345 CHEMBL543659 Bioactive 5-[(E)-3-[[2-[2,4-dichloro-N-methyl-3-[(2-methylquinolin-8-yl)oxymethyl]anilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-pyridin-4-ylpyridine-2-carboxamide;trihydrochloride
CFAMM00279199 CHEMBL542232 Bioactive 5-[(E)-3-[[2-[2,4-dichloro-N-methyl-3-[(2-methylquinolin-8-yl)oxymethyl]anilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylpyridine-2-carboxamide;dihydrochloride
CFAMM00279325 CHEMBL542173 Bioactive N-[4-[(E)-3-[[2-[2,4-dichloro-3-[[4-(dimethylamino)-2-methylquinolin-8-yl]oxymethyl]-N-methylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]phenyl]pyridine-4-carboxamide;hydrochloride
CFAMM00279206 CHEMBL329758 Bioactive SureCN7975793
CFAMM00279338 CHEMBL553614 Bioactive (E)-N-[2-[2,4-dichloro-N-methyl-3-[(2-methylquinolin-8-yl)oxymethyl]anilino]-2-oxoethyl]-3-[6-(2-oxopyrrolidin-1-yl)pyridin-3-yl]prop-2-enamide;dihydrochloride
CFAMM00279232 CHEMBL537927 Bioactive 4-[(E)-3-[[2-[2,4-dichloro-N-methyl-3-[(2-methyl-4-piperidin-1-ylquinolin-8-yl)oxymethyl]anilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-pyridin-4-ylbenzamide;hydrochloride
CFAMM00279305 CHEMBL544599 Bioactive SureCN7747399
CFAMM00279185 CHEMBL97393 Bioactive SureCN8018880
CFAMM00279259 CHEMBL555305 Bioactive 5-[(E)-3-[[2-[2,4-dichloro-3-[[4-(dimethylamino)-2-methylquinolin-8-yl]oxymethyl]-N-methylanilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N,N-dimethylpyridine-2-carboxamide;hydrochloride
CFAMM00279318 CHEMBL98459 Bioactive SureCN6959130
CFAMM00279370 CHEMBL130436 Bioactive SureCN8364325
CFAMM00279298 CHEMBL554127 Bioactive (E)-3-(6-acetamidopyridin-3-yl)-N-[2-[2,4-dichloro-3-[[4-(dimethylamino)-2-methylquinolin-8-yl]oxymethyl]-N-methylanilino]-2-oxoethyl]prop-2-enamide;hydrochloride
CFAMM00279311 CHEMBL553762 Bioactive 4-[(E)-3-[[2-[2,4-dichloro-N-methyl-3-[(2-methyl-4-morpholin-4-ylquinolin-8-yl)oxymethyl]anilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-pyridin-4-ylbenzamide;hydrochloride
CFAMM00279278 CHEMBL553843 Bioactive (E)-3-(6-acetamidopyridin-3-yl)-N-[2-oxo-2-[N,2,4-trimethyl-3-[(2-methylquinolin-8-yl)oxymethyl]anilino]ethyl]prop-2-enamide;dihydrochloride
CFAMM00279191 CHEMBL553897 Bioactive 4-[(E)-3-[[2-[2,4-dichloro-N-methyl-3-[(2-methyl-4-piperidin-1-ylquinolin-8-yl)oxymethyl]anilino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-(pyridin-2-ylmethyl)benzamide;hydrochloride
CFAMM00279291 CHEMBL99869 Bioactive FR190997
CFAMM00279184 CHEMBL328509 Bioactive SureCN6969534
CFAMM00279283 DNC009756 Investigative Drug FR-173657

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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