CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2892
Family Name Cytochrome P450 3A4 Inhibitor 1,2-diacetoxylycorine Family
No. of Seeds 4 No. of Other Members 19
Family Centroid CFAMM00279422 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Cytochrome P450 3A4 and Tumor necrosis factor Binder Superfamily
Class Class 719

Cousin Family NamesSeedsMembers
Nicotinic acetylcholine receptor alpha subunit Ligand benzylis... 4 18
Neuronal acetylcholine receptor subunit alpha-2 Ligand Metocur... 18 169
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Hydrastine family 6 115
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Tubulin beta chain Inhibitor Colchinol Family 3 109
D(2) dopamine receptor and Sodium-dependent dopamine transport... 6 10
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-ch... 2 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 2 26
Endothelin-1 receptor ligand 2-[(1R,3S)-1-(1,3-benzodioxol-5-y... 3 10
Cytochrome P450 3A4 inhibitor N-[(2S,3S)-2-(1,3-benzodioxol-5-... 4 5
Benzazepines Metabolite N-Methylporphyroxine Family 1 2


External ID

Functional Category

Molecule Name

CFAMM00279423 DNC009760 Investigative Drug 2-tert-Butyldimethylsilyloxylycorine
CFAMM00279422 DNC009763 Investigative Drug 1,2-Diacetoxylycorine
CFAMM00279421 DNC009762 Investigative Drug 1-Acetoxylycorine
CFAMM00279424 DNC009761 Investigative Drug 1-Acetoxy-2-tert-butyldimethylsilyl-oxylycorine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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