CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2912
Family Name Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h-pyrrolo[2,3-b]pyridine Family
No. of Seeds 17 No. of Other Members 59
Family Centroid CFAMM00279681 Functional Category Investigative Drug
Superfamily Tyrosine-protein kinase Lck and Hepatocyte growth factor receptor Binder Superfamily
Class Class 2142

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Mast/stem cell growth factor receptor Kit and Vascular endothe... 6 34
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Hepatocyte growth factor receptor Ligand SGX523 Family 1 15
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Corticotropin-releasing factor receptor 1 Ligand CRA1000 Family 4 39
D(4) dopamine receptor Ligand L-745,870 Family 30 205
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Metabotropic glutamate receptor 5 Ligand 4-(4-chlorophenylthio... 4 17
Vascular endothelial growth factor receptor 2 Ligand 3-(4-amin... 2 5
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Protein farnesyltransferase subunit beta Inhibitor BMS-316810 ... 11 18
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 13 100
5-hydroxytryptamine receptor 6 ligand AGN-PC-0BIUF2 family 25 11
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 4
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 6 60
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 1 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
5-hydroxytryptamine receptor 6 ligand 6-chloro-5-[1-(1-methylp... 9 0
5-hydroxytryptamine receptor 6 ligand 3-(5-chlorothiophen-2-yl... 6 1
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Pol polyprotein and Reverse transcriptase/RNaseH inhibitor AC1... 6 11
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Coagulation factor X and Trypsin-1 inhibitor 1-(3-carbamimidoy... 4 1
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
5-hydroxytryptamine receptor 6 ligand 3-(benzenesulfonyl)-N,5-... 4 1
Platelet-activating factor receptor ligand 6-(4-fluorophenyl)-... 1 3
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Glucose-dependent insulinotropic receptor ligand 4-({Ethyl-[1-... 6 12
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 1
Neuropeptide Y receptor type 5 and Cytochrome P450 1A2 ligand ... 8 19
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Neuropeptide Y receptor type 5 ligand 2-(3-phenylpiperidin-1-y... 6 2
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 3 4
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 10
5-hydroxytryptamine receptor 6 ligand 3-(3-chlorophenyl)sulfon... 8 1
5-hydroxytryptamine receptor 6 ligand 3-(3-bromophenyl)sulfony... 3 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-076AT1 family 7 0
Nicotinamide phosphoribosyltransferase and Cytochrome P450 2C9... 4 5
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 4 5
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3,5-di... 4 8
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(benzen... 4 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 3 1
Cathepsin K inhibitor SureCN4141224 family 3 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Cannabinoid receptor 2 ligand 4-[[2-tert-butyl-1-(cyclohexylme... 2 0
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
Prostaglandin G/H synthase 2 inhibitor 2-(4-methylsulfonylphen... 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 1 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 4 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... 1 0
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-a]pyridine der... 4 0
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 3
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-[3-(2-hydroxyeth... 2 1
Neuropeptide Y receptor type 5 ligand AGN-PC-01NS1A family 7 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07R77D fa... 2 7
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 1 0
Cyclooxygenase 2 and Prostaglandin G/H synthase 1 inhibitor Su... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name
CFAMM00279691 CHEMBL577687 Bioactive AGN-PC-07CP8Y
CFAMM00279740 CHEMBL568672 Bioactive AGN-PC-07CP71
CFAMM00279683 CHEMBL392899 Bioactive AGN-PC-046EIO
CFAMM00279696 CHEMBL240922 Bioactive 3-(2-fluorophenyl)sulfonyl-1-pyrrolidin-3-ylpyrrolo[2,3-b]pyridine
CFAMM00279730 CHEMBL401019 Bioactive 3-(2-fluorophenyl)sulfonyl-1-piperidin-3-ylpyrrolo[2,3-b]pyridine
CFAMM00279744 CHEMBL565976 Bioactive SureCN3885906
CFAMM00279757 CHEMBL393158 Bioactive AGN-PC-00BADU
CFAMM00279715 CHEMBL236576 Bioactive 3-(4-fluorophenyl)sulfonyl-1-pyrrolidin-3-ylpyrrolo[2,3-b]pyridine
CFAMM00279728 CHEMBL235070 Bioactive 3-(benzenesulfonyl)-1-piperidin-3-ylpyrrolo[2,3-b]pyridine
CFAMM00279742 CHEMBL584049 Bioactive AGN-PC-07CP91
CFAMM00279708 CHEMBL400627 Bioactive 3-(3-fluorophenyl)sulfonyl-1-pyrrolidin-3-ylpyrrolo[2,3-b]pyridine
CFAMM00279734 CHEMBL565730 Bioactive AGN-PC-07CP8Z
CFAMM00279748 CHEMBL565745 Bioactive SureCN3888769
CFAMM00279692 CHEMBL576315 Bioactive SureCN3898702
CFAMM00279733 CHEMBL565731 Bioactive AGN-PC-07CP90
CFAMM00279745 DNC010089 Investigative Drug WAY-208466
CFAMM00279681 DNC009824 Investigative Drug 3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Statistics of CFAM Database
 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27075 visits since 2014 .........

 


Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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