CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2913
Family Name Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3,2-b]pyridine Family
No. of Seeds 2 No. of Other Members 16
Family Centroid CFAMM00279763 Functional Category Investigative Drug with Human Metabolite
Superfamily Indoleamine 2,3-dioxygenase 1 and Hepatocyte growth factor receptor Binder Superfamily
Class Class 2594

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Benzodiazepine receptor Ligand Midazolam Family 5 160
Neuronal acetylcholine receptor subunit alpha-4 Ligand Varenic... 3 54
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Histamine H1 receptor Ligand Mizolastine Family 14 603
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 23 63
HCV NS4B protein Inhibitor Clemizole Family 2 43
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
Amg 423 family 7 47
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 3 15
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 22
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
Metabotropic glutamate receptor 5 Ligand 3-(3-pyridin-2-yl-pyr... 4 24
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Aromatase Inhibitor NSC-356781 Family 3 10
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Kinesin-like protein KIF11 Inhibitor 2-(trifluoromethyl)-9h-ca... 5 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 9
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 1
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 3
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 6
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Acetylcholinesterase Inhibitor Infractopicrin Family 1 1
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Trypsin Inhibitor 4-(5-nitro-indol-1-ylmethyl)-benzamidine Family 2 0
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 4 5
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 3
Hepatocyte growth factor receptor ligand AGN-PC-08XYH0 family 8 4
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SQ6 family 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 4
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 4
Cathepsin K inhibitor SureCN4141224 family 3 0
5-hydroxytryptamine receptor 1D ligand AGN-PC-01NTBS family 1 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
Thromboxane-A synthase inhibitor AGN-PC-07BYVF family 1 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Lysine-specific demethylase 4E and Lethal(3)malignant brain tu... 1 1
Multidrug resistance-associated protein 1 and Multidrug resist... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00279764 DNC009826 Investigative Drug 1-(2-nitrophenethyl)-1H-pyrrolo[3,2-b]pyridine
CFAMM00279763 DNC009825 Investigative Drug 1-benzyl-1H-pyrrolo[3,2-b]pyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48686 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543