CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2920
Family Name Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinopropoxy)phenyl)-3-phenylurea Family
No. of Seeds 24 No. of Other Members 102
Family Centroid CFAMM00279919 Functional Category Investigative Drug with Natural Product
Superfamily Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinopropoxy)phenyl)-3-phenylurea Superfamily
Class Class 2603

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand phenylpiperazine derivative Arip... 3 53
Potassium voltage-gated channel subfamily H member 2 Ligand Do... 5 30
Acetylcholinesterase Inhibitor Neostigmine Family 4 76
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Sodium channel protein type 10 subunit alpha and Sodium channe... 1 7
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
Calcium-activated potassium channel subunit alpha-1 Ligand Chl... 2 15
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
Cholesteryl ester transfer protein Inhibitor CP-800569 Family 5 81
D(2) dopamine receptor Ligand Aplindore Fumarate Family 2 30
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 3 67
Substance-P receptor Ligand Ezlopitant Family 10 207
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 23
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
Beta-3 adrenergic receptor Ligand Cgp 12177 Family 3 8
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 6 Ligand Sb 258585 Family 11 121
Inosine-5'-monophosphate dehydrogenase Inhibitor VX-148 Family 2 3
Histamine H3 receptor Ligand UCL1972 Family 3 23
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 20
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Liga... 40 90
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Alpha-1A adrenergic receptor Ligand Ro-11-04253 Family 1 1
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Histone deacetylase 1 Inhibitor 7-(4-(dimethylamino)phenoxy)-n... 2 1
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 11 13
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 12 44
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Fatty-acid amide hydrolase 1 Inhibitor 2-fluorophenyl 4-(octyl... 15 9
Fatty-acid amide hydrolase 1 Inhibitor Propan-2-one O-4-(hexyl... 12 4
Fatty-acid amide hydrolase 1 Inhibitor Benzaldehyde O-4-ethoxy... 21 4
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Fatty-acid amide hydrolase 1 Inhibitor Phenmedipham Family 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 9
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 28 24
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 7
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Fatty-acid amide hydrolase 1 Inhibitor 4-nitrophenyl 4-benzylp... 5 35
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
Beta-1 adrenergic receptor ligand 1-[2-[[(2S)-3-(2-cyanophenox... 10 4
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 4 6
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 18
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 0
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 1 1
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 8
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 0
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 10
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-087THW family 1 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN2729784 family 3 9
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 9 37
Transient receptor potential cation channel subfamily V member... 3 15
Survival motor neuron protein and DNA-(apurinic or apyrimidini... 1 5
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 3 1
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor SureCN... 2 11
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Sodium-dependent serotonin transporter inhibitor SureCN3890472... 2 0
Survival motor neuron protein and ATP-dependent DNA helicase Q... 1 4
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 2 4
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 11 12
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-088O2I family 3 3
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-088O2K family 2 0
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Trace amine-associated receptor 1 ligand EPPTB family 4 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Gonadotropin-releasing hormone receptor ligand SureCN5756131 f... 5 7
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 5 2
Peptide deformylase inhibitor 2-[(2R)-2-(cyclopentylmethyl)-3-... 3 2
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 1
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 16 6
Orexin receptor type 2 and Orexin receptor type 1 ligand 4-(3,... 1 0
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 2 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 4 19
Bifunctional epoxide hydrolase 2 inhibitor 1-(1-adamantyl)-3-[... 2 1
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(4... 4 2
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(4... 10 0
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(2... 2 0
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-(2,... 2 11
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 3 3
D(2) dopamine receptor and Muscarinic acetylcholine receptor M... 1 0
Translocator protein inhibitor N-methyl-2-[5-(N-methylanilino)... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Motilin receptor ligand SureCN14564469 family 1 6
Galanin receptor type 3 and Alpha-1A adrenergic receptor ligan... 2 16
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 0
Cathepsin K inhibitor (1R,2R)-N-(cyanomethyl)-2-[4-(3-methoxyp... 2 1
Bifunctional epoxide hydrolase 2 inhibitor SureCN3178516 family 3 1
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 10 1
Translocator protein inhibitor CHEMBL2332256 family 1 0
Translocator protein inhibitor CHEMBL2332259 family 2 0
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 8
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 3 0
Nociceptin receptor and Mu-type opioid receptor ligand SureCN7... 13 22
Histamine H3 receptor and Histamine receptor H3 ligand 1-[4-[3... 2 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-(3,5-... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand N-ethyl... 8 3
Poly [ADP-ribose] polymerase 1 inhibitor 6-[[4-(4-chlorophenyl... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-ethylbutanoyl)... 11 0
Transient receptor potential cation channel subfamily M member... 2 13
Coagulation factor X and Cationic trypsin inhibitor 3-[(E)-3-[... 3 2
C-X-C chemokine receptor type 3 ligand 1-[1-[(9-acetyl-9-azabi... 1 0
Alpha-1D adrenergic receptor and D(2) dopamine receptor ligand... 3 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1A ligand AGN-PC-0034EG family 5 2
5-hydroxytryptamine receptor 1A ligand (1R,2R)-2-[4-(2,3-dihyd... 2 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 10
Neuropeptide Y receptor type 5 ligand 3-[4-(4-fluorophenoxy)ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZ6 family 3 6
Substance-P receptor ligand CP 141938 family 1 0
5-hydroxytryptamine receptor 1A ligand AGN-PC-00FVK4 family 1 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 0
Sigma non-opioid intracellular receptor 1 ligand (5S)-5-[(4-hy... 1 5
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-00RZQT family 3 4
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJY family 5 4
Histamine H3 receptor ligand AGN-PC-077MDJ family 2 1
Hormone-sensitive lipase inhibitor [4-[(4-tert-butylcyclohexan... 2 1
Kappa-type opioid receptor ligand AGN-PC-077Q4X family 1 1
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-[2-... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 0
Sterol O-acyltransferase 1 inhibitor SureCN6152927 family 7 3
Histamine H3 receptor ligand AGN-PC-07ZCFA family 1 0
Peptide deformylase inhibitor (2S)-N-(cyclopropylmethyl)-N-[2-... 1 0
C-C chemokine receptor type 3 ligand SureCN6700764 family 2 2
Hormone-sensitive lipase and Acetylcholinesterase inhibitor Su... 2 0
Prelamin-A/C and Nonstructural protein 1 inhibitor CHEMBL14536... 1 2
Transient receptor potential cation channel subfamily V member... 2 7
DNA polymerase III PolC-type inhibitor 6-(3-ethyl-4-methylanil... 1 0
Histamine H3 receptor ligand 1-naphthalen-1-yl-3-[4-(3-pyrroli... 1 0
D-amino-acid oxidase inhibitor 3-hydroxy-7-methoxy-1H-benzimid... 1 1
D(2) dopamine receptor ligand 5-[4-[4-(2,3-dichlorophenyl)pipe... 1 0
C-X-C chemokine receptor type 3 ligand 1-[1-[[(1S,5R)-6,6-dime... 2 3
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 1
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN9818603 f... 2 2
D(2) dopamine receptor and D(3) dopamine receptor ligand 1-(3-... 2 0
Prelamin-A/C and Ras-related protein Rab-9A inhibitor CHEMBL13... 1 2
Leukotriene A-4 hydrolase inhibitor AGN-PC-087BON family 1 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075HBO ... 2 44
Cholinesterase inhibitor (13-methyl-5,6,8,13a-tetrahydroisoqui... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-[2-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00279936 CHEMBL551521 Bioactive SureCN4266421
CFAMM00279865 CHEMBL568915 Bioactive SureCN4258016
CFAMM00279945 CHEMBL561383 Bioactive SureCN4262609
CFAMM00279935 CHEMBL456836 Bioactive SureCN4261127
CFAMM00279844 CHEMBL550655 Bioactive SureCN4259984
CFAMM00279853 CHEMBL457032 Bioactive SureCN4258642
CFAMM00279982 CHEMBL564360 Bioactive SureCN4259533
CFAMM00279843 CHEMBL549902 Bioactive SureCN4262990
CFAMM00279917 CHEMBL2387305 Bioactive 1-(4-chlorophenyl)-3-[4-(3-piperidin-1-ylpropoxy)phenyl]urea
CFAMM00279915 CHEMBL2387301 Bioactive 1-[4-[3-(diethylamino)propoxy]phenyl]-3-(2,4-difluorophenyl)urea
CFAMM00279886 CHEMBL383800 Bioactive 1-[4-methoxy-3-(2-piperidin-1-ylethoxy)phenyl]-3-phenylimidazolidin-2-one
CFAMM00279922 CHEMBL560982 Bioactive SureCN4254907
CFAMM00279859 CHEMBL551061 Bioactive SureCN4264251
CFAMM00279921 CHEMBL458166 Bioactive SureCN4256223
CFAMM00279919 DNC009843 Investigative Drug 1-(3-(3-morpholinopropoxy)phenyl)-3-phenylurea
CFAMM00279954 DNC009844 Investigative Drug 1-(4-(3-morpholinopropoxy)phenyl)-3-phenylurea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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