CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2921
Family Name Coagulation factor X Inhibitor BMS-269223 Family
No. of Seeds 15 No. of Other Members 58
Family Centroid CFAMM00280014 Functional Category Investigative Drug
Superfamily Coagulation factor X and Prothrombin Binder Superfamily
Class Class 2604

Cousin Family NamesSeedsMembers
Substance-K receptor Ligand MEN-14933 Family 13 154
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Coagulation factor X and Prothrombin Inhibitor BMS-344577 Family 13 12
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Macrophage metalloelastase and Collagenase 3 inhibitor SureCN4... 11 3
Histamine H3 receptor ligand 3-[[2-[2-[(2R)-2-methylpyrrolidin... 3 1
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Histamine H3 receptor ligand N-[2-[2-[(2R)-2-methylpyrrolidin-... 4 0
Coagulation factor X inhibitor (3S)-3-[[(Z)-1-[(2-methyl-1-ben... 1 0
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Trypsin-1 inhibitor N-[7-amino-1-[2-(4-carbamoylphenyl)ethylam... 1 0
Proteinase-activated receptor 1 ligand 2-[[2-[[2-[acetyl-[(E)-... 1 0


External ID

Functional Category

Molecule Name

CFAMM00280033 CHEMBL566210 Bioactive benzoylguanidine, 13
CFAMM00280039 CHEMBL198629 Bioactive 4-hydroxybutyl (Z)-2-cyano-3-[(2-methyl-1-benzofuran-5-yl)amino]-3-[[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]amino]prop-2-enoate
CFAMM00280053 CHEMBL577960 Bioactive 3-N,3-N-dimethyl-1-N-[N-(2-methyl-1-benzofuran-5-yl)-N'-[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]carbamimidoyl]benzene-1,3-dicarboxamide
CFAMM00280080 CHEMBL572054 Bioactive 4-N-[N-(2-methyl-1-benzofuran-5-yl)-N'-[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]carbamimidoyl]benzene-1,4-dicarboxamide
CFAMM00280032 CHEMBL584912 Bioactive sulfonylguanidine, 5
CFAMM00280052 CHEMBL577961 Bioactive benzoylguanidine, 17
CFAMM00280031 CHEMBL565588 Bioactive heteroaroylguanidine, 26
CFAMM00280015 CHEMBL451280 Bioactive 1-benzoyl-N-[N-(2-methyl-1-benzofuran-5-yl)-N'-[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]carbamimidoyl]piperidine-4-carboxamide
CFAMM00280051 CHEMBL577962 Bioactive benzoylguanidine, 18
CFAMM00280030 CHEMBL570636 Bioactive benzoylguanidine, 14
CFAMM00280050 CHEMBL577963 Bioactive 4-N,4-N-dimethyl-1-N-[N-(2-methyl-1-benzofuran-5-yl)-N'-[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]carbamimidoyl]benzene-1,4-dicarboxamide
CFAMM00280083 CHEMBL585283 Bioactive heteroaroylguanidine, 25
CFAMM00280035 CHEMBL466965 Bioactive benzoylguanidine, 12
CFAMM00280034 CHEMBL552166 Bioactive 1-cyano-2-[(3S)-1-[2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-2-oxoethyl]-2-oxoazepan-3-yl]-3-(2-methyl-1-benzofuran-5-yl)guanidine
CFAMM00280014 DNC009845 Investigative Drug BMS-269223

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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