CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2928
Family Name Kappa-type opioid receptor and Potassium voltage-gated channel subfamily H member 2 Ligand MK-1925 Family
No. of Seeds 10 No. of Other Members 10
Family Centroid CFAMM00280239 Functional Category Investigative Drug
Superfamily Kappa-type opioid receptor and Potassium voltage-gated channel subfamily H member 2 Ligand MK-1925 Superfamily
Class Class 2607

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Histamine H1 receptor Ligand Triprolidine Family 19 316
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
Prothrombin Inhibitor 4-[3-(4-chlorophenyl)-1h-pyrazol-5-yl]pi... 7 39
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
Metabotropic glutamate receptor 5 Ligand 3-(3-pyridin-2-yl-pyr... 4 24
Acetylcholinesterase Inhibitor 3-[2-(1-benzyl-piperidin-4-yl)-... 2 9
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 6
Calcium-activated potassium channel subunit alpha-1 Ligand 1-(... 3 3
Glucocorticoid receptor and Oxysterols receptor LXR-alpha Liga... 4 13
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Cytochrome P450 3A4 Inhibitor 5-(2-phenethylpiperazin-1-yl)-1h... 12 35
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Orexin receptor type 2 and Orexin receptor type 1 ligand AGN-P... 7 19
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Corticotropin-releasing factor receptor 1 ligand 3,7-dimethyl-... 3 4
Smoothened homolog inhibitor AC1P6IWE family 1 0
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00AP1L ... 14 7
Sodium-dependent serotonin transporter and Sodium-dependent no... 14 6
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Lysosomal Pro-X carboxypeptidase inhibitor [(3S,4R)-1-tert-but... 20 13
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
5-hydroxytryptamine receptor 7 ligand AS-19 (drug) family 1 1
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 3 0
Casein kinase I isoform delta and Casein kinase I isoform epsi... 1 0
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 5 0
Glucocorticoid receptor ligand 6-benzyl-1-(4-fluorophenyl)-4a-... 2 0
Methionine aminopeptidase 2 inhibitor SureCN5020175 family 1 1
Sigma non-opioid intracellular receptor 1 ligand 1-phenyl-4-(2... 1 0
Progesterone receptor ligand AGN-PC-074LWG family 1 1
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Nociceptin receptor ligand SureCN3543370 family 1 0
Nociceptin receptor ligand SureCN3542441 family 1 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 6 4
Transient receptor potential cation channel subfamily V member... 1 0
Dipeptidyl peptidase 4 inhibitor (3R)-3-amino-1-(3-methyl-6,7-... 6 1
Dipeptidyl peptidase 4 inhibitor (3R)-3-amino-1-[3-(4-chloroph... 2 0
Extracellular calcium-sensing receptor ligand SureCN2220343 fa... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name
CFAMM00280241 CHEMBL560468 Bioactive SureCN3540469
CFAMM00280233 CHEMBL541511 Bioactive SureCN3541822
CFAMM00280240 CHEMBL551002 Bioactive (1S,3R)-N-[[5-(3,4-difluorophenyl)-1,4-dimethylpyrazol-3-yl]methyl]-3-fluorocyclopentan-1-amine
CFAMM00280232 CHEMBL562932 Bioactive SureCN3543309
CFAMM00280225 CHEMBL557623 Bioactive SureCN3541731
CFAMM00280231 CHEMBL173988 Bioactive 3-(4-fluorophenyl)-1-pentyl-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridine;methanesulfonic acid
CFAMM00280230 CHEMBL561732 Bioactive SureCN3547362
CFAMM00280223 CHEMBL560667 Bioactive MK-1925
CFAMM00280228 CHEMBL173570 Bioactive 3-(4-fluorophenyl)-1-(1-phenylethyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridine;methanesulfonic acid
CFAMM00280239 DNC009883 Investigative Drug MK-1925

Statistics of CFAM Database
 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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