CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2937
Family Name Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family
No. of Seeds 27 No. of Other Members 48
Family Centroid CFAMM00280428 Functional Category Investigative Drug
Superfamily Prostaglandin G/H synthase 2 and Corticotropin-releasing factor receptor 1 Binder Superfamily
Class Class 857

Cousin Family NamesSeedsMembers
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 5 60
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 4 14
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
Transient receptor potential cation channel subfamily V member... 15 457
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
PF-3758309 family 1 8
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CRA1000 Family 4 39
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Peptide deformylase, mitochondrial Inhibitor 5-phenylsulfanyl-... 5 23
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Corticotropin-releasing factor receptor 1 Ligand N-mesityl-6-m... 3 2
Corticotropin-releasing factor receptor 1 ligand N-(2-bromo-4-... 5 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 8
Corticotropin-releasing factor receptor 1 ligand AGN-PC-01ZUJC... 2 1
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 1 7
5-hydroxytryptamine receptor 6 ligand AGN-PC-03P3TZ family 6 88
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 1
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Adenosine kinase inhibitor SureCN8183719 family 2 3
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Vascular endothelial growth factor receptor 2 ligand urea deri... 3 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 8
Aurora kinase A and Aurora kinase B inhibitor 2-[[5-chloro-2-[... 3 7
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0760... 4 0
Growth hormone secretagogue receptor type 1 ligand SureCN63605... 5 7
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 2-[4... 5 5
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 3 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
Dihydrofolate reductase inhibitor WR 158122 family 1 0
Prostaglandin G/H synthase 2 inhibitor 6-ethoxy-2-(4-methylsul... 5 1
Prostaglandin G/H synthase 2 inhibitor 2-(4-methylsulfonylphen... 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 0
Dihydrofolate reductase inhibitor 5-[4-[(3,4-dichlorophenyl)me... 1 0
Histamine H4 receptor and Histamine H1 receptor ligand 6-chlor... 1 0
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 3 0
Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin... 7 2
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 2 9
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 3 3
Prostaglandin G/H synthase 2 inhibitor AGN-PC-073UDQ family 2 0
Histone-lysine N-methyltransferase 2A and Huntingtin inhibitor... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00280443 CHEMBL271338 Bioactive 2-(4-methylsulfonylphenyl)-N-(thiophen-2-ylmethyl)-6-(trifluoromethyl)pyrimidin-4-amine
CFAMM00280430 CHEMBL551829 Bioactive SureCN5785800
CFAMM00280422 CHEMBL561950 Bioactive AGN-PC-07C4CR
CFAMM00280465 CHEMBL561086 Bioactive AGN-PC-07C3UD
CFAMM00280458 CHEMBL207754 Bioactive AGN-PC-0760XN
CFAMM00280471 CHEMBL205995 Bioactive 5-[4-[(4-methylsulfonylphenyl)methylamino]phenyl]-6-octylpyrimidine-2,4-diamine
CFAMM00280486 CHEMBL551148 Bioactive SureCN5787610
CFAMM00280421 CHEMBL273118 Bioactive N-(1-benzothiophen-2-ylmethyl)-2-(4-methylsulfonylphenyl)-6-(trifluoromethyl)pyrimidin-4-amine
CFAMM00280456 CHEMBL559613 Bioactive AGN-PC-07C4T0
CFAMM00280470 CHEMBL562791 Bioactive AGN-PC-07C6QL
CFAMM00280420 CHEMBL203578 Bioactive SureCN6363915
CFAMM00280411 CHEMBL549393 Bioactive AGN-PC-07C5BZ
CFAMM00280440 CHEMBL558728 Bioactive AGN-PC-07C7BF
CFAMM00280455 CHEMBL563322 Bioactive AGN-PC-07C3SW
CFAMM00280483 CHEMBL382033 Bioactive SureCN6361316
CFAMM00280426 CHEMBL203280 Bioactive SureCN6360495
CFAMM00280410 CHEMBL205374 Bioactive SureCN6363744
CFAMM00280439 CHEMBL551830 Bioactive AGN-PC-07C5BN
CFAMM00280454 CHEMBL424860 Bioactive 6-heptyl-5-[4-[(4-methylsulfonylphenyl)methylamino]phenyl]pyrimidine-2,4-diamine
CFAMM00280424 CHEMBL561891 Bioactive SureCN5675609
CFAMM00280481 CHEMBL203373 Bioactive SureCN6361334
CFAMM00280431 CHEMBL206486 Bioactive SureCN6359093
CFAMM00280444 CHEMBL206820 Bioactive 6-[(4-fluoroanilino)methyl]-5-[4-[(4-methylsulfonylphenyl)methylamino]phenyl]pyrimidine-2,4-diamine
CFAMM00280488 CHEMBL551418 Bioactive AGN-PC-07C5AL
CFAMM00280428 DNC009902 Investigative Drug GW-637185X

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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