CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2949
Family Name Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-phenylacetamidomethyl)benzenesulfonamide Family
No. of Seeds 6 No. of Other Members 19
Family Centroid CFAMM00280618 Functional Category Investigative Drug
Superfamily Carbonic anhydrase 2 and Carbonic anhydrase 1 Binder Superfamily
Class Class 905

Cousin Family NamesSeedsMembers
SUR1-type K(ATP) channel and SUR2-type K(ATP) channel Ligand T... 3 35
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Sodium channel protein type 5 subunit alpha Ligand Indecainide... 2 41
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
ATP-sensitive inward rectifier potassium channel 10 Ligand Ace... 2 64
DNA Binder Procarbazine Family 8 358
Cathepsin K Inhibitor Odanacatib Family 33 84
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Chloride channel protein 2 Ligand Acid-activated Omeprazole Fa... 1 1
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Thymidylate synthase Inhibitor N-[tosyl-d-prolinyl]amino-ethan... 1 10
Thymidylate synthase Inhibitor Sp-876 Family 7 117
Penicillin-binding protein 1B Inhibitor N-benzoyl-d-alanine Fa... 1 40
Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... 12 44
Carbonic anhydrase 2 Inhibitor 4-(2-aminoethyl)benzenesulfonam... 3 30
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic ... 7 13
Integrin beta-3 Inhibitor L-750034 Family 7 38
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-hydr... 3 14
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Alpha-2A adrenergic receptor Ligand SK&F-29661 Family 3 42
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 2-acet... 6 2
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 2-pent... 4 5
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 1 3
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 2-valp... 8 5
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Saccha... 2 13
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Disintegrin and metalloproteinase domain-containing protein 17... 7 39
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
Aminopeptidase N Inhibitor 2-benzyl-n1-hydroxy-n3-(4-phenylbut... 5 3
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Calpain Inhibitor SJA-6017 Family 2 12
Trypsin Inhibitor Benzamidrazone Analogue Family 16 6
5-hydroxytryptamine receptor 6 ligand N-[[(1R)-6-(benzenesulfo... 8 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 6
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor AGN-PC... 2 5
Calpain-1 catalytic subunit inhibitor 6-chloro-2-methyl-1,1-di... 3 9
72 kDa type IV collagenase and Neutrophil collagenase inhibito... 8 4
Acetylcholinesterase and Butyrylcholinesterase inhibitor N-[2-... 3 7
Cathepsin L1 and Cathepsin B inhibitor (2S)-3-methyl-N-[(2S)-4... 7 24
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-044L... 6 7
Disintegrin and metalloproteinase domain-containing protein 17... 6 5
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 1
Neprilysin inhibitor AGN-PC-047EOK family 7 4
Neprilysin inhibitor AGN-PC-047EP1 family 1 0
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 0
D(2) dopamine receptor and D(3) dopamine receptor ligand 1,1-d... 2 7
Cannabinoid receptor 2 ligand 4-methyl-3-piperidin-1-ylsulfony... 2 0
Acetylcholinesterase inhibitor N-[2-(1-benzylpiperidin-4-yl)et... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-met... 8 13
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Carbonic anhydrase 12 and Carbonic anhydrase 2 inhibitor AGN-P... 5 0
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor 2-[2-[... 10 5
Poly [ADP-ribose] polymerase 1 inhibitor SureCN2769748 family 1 1
Bifunctional epoxide hydrolase 2 inhibitor 1-(2-bromophenyl)su... 2 5
Bifunctional epoxide hydrolase 2 inhibitor N-cycloheptyl-1-(2,... 7 8
Bifunctional epoxide hydrolase 2 inhibitor N-cycloheptyl-1-(2,... 1 0
B1 bradykinin receptor ligand N-[(4S)-1-ethyl-3,3-dimethylpipe... 10 4
Cathepsin K and Cathepsin L1 inhibitor N-[1-(cyanomethylcarbam... 2 0
Proteasome subunit beta type-5 inhibitor (2S)-N'-(2,2-dimethyl... 2 9
Dipeptidyl peptidase 4 inhibitor 4-cyano-N-[4-[(2S)-2-cyanopyr... 1 1
Bifunctional epoxide hydrolase 2 inhibitor 1-(2,4-dimethylphen... 4 8
Cannabinoid receptor 2 ligand AGN-PC-04VLWN family 9 4
Cannabinoid receptor 2 ligand N-cyclohexyl-4-propan-2-yl-3-pyr... 2 2
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Neutrophil elastase inhibitor diethyl (1,1,3-trioxo-4-propan-2... 2 0
5-hydroxytryptamine receptor 1A and Alpha-2B adrenergic recept... 2 2
72 kDa type IV collagenase and Stromelysin-1 inhibitor (3R)-3-... 3 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 1
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[ethyl-[2-(4... 1 1
Growth hormone secretagogue receptor type 1 ligand [(3S)-3-ami... 2 6
Growth hormone secretagogue receptor type 1 ligand [(3R)-3-ami... 2 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor N-... 9 0
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2J2 inhib... 5 0
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor AGN-PC... 6 4
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor 2-[car... 1 0
Calpain-1 catalytic subunit and Cathepsin B inhibitor (4S)-3-(... 1 0
Caspase-3 inhibitor 3-oxo-N-(2-phenylethyl)-1,2-benzothiazole-... 1 3
Lethal(3)malignant brain tumor-like protein 3 and Lethal(3)mal... 1 0
Tyrosine-protein kinase Lck inhibitor 1-[2-[bis[3-[bis[3-[bis(... 1 0
Bifunctional epoxide hydrolase 2 and Lysosomal alpha-glucosida... 9 3
Secreted frizzled-related protein 1 and Proto-oncogene Wnt-3 i... 2 5
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor AGN-PC... 2 9
Calpain-1 catalytic subunit and Cathepsin B inhibitor [(3R,5S)... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00280628 CHEMBL293628 Bioactive N-(cyclohexylmethyl)-4-sulfamoylbenzamide
CFAMM00280601 CHEMBL294548 Bioactive N-octyl-4-sulfamoylbenzamide
CFAMM00280619 DNC009941 Investigative Drug 4-(2-Phenylacetamidoethyl)benzenesulfonamide
CFAMM00280596 DNC012160 Investigative Drug 2-Propyl-pentanoic acid 4-sulfamoyl-benzylamide
CFAMM00280618 DNC009940 Investigative Drug 4-(2-Phenylacetamidomethyl)benzenesulfonamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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