CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2954
Family Name Histamine H3 receptor Ligand 2-(1,4'-bipiperidin-1'-yl)thiazolo[4,5-b]pyridine Family
No. of Seeds 2 No. of Other Members 23
Family Centroid CFAMM00280681 Functional Category Investigative Drug
Superfamily Histamine H3 receptor Ligand 2-(1,4'-bipiperidin-1'-yl)thiazolo[4,5-b]pyridine Superfamily
Class Class 2616

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Cyclin-dependent kinase 2 Inhibitor 4-(2,4-dimethyl-thiazol-5-... 2 14
TGF-beta receptor type-1 Ligand 4-pyridin-2-yl-5-quinolin-4-yl... 4 23
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 3 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethy... 2 2
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 1 0
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Platelet-activating factor receptor ligand Foropafant family 2 0
Histamine H3 receptor ligand AGN-PC-09QLRJ family 2 0
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Neuropeptide Y receptor type 5 ligand 2-fluoro-N-[5-[(4-pyridi... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 1
Serine/threonine-protein kinase Chk1 inhibitor 3-[5-[2-[(4-mor... 2 3
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
Cyclin-dependent kinase 6 and Cyclin-dependent kinase 4 inhibi... 1 0
Metabotropic glutamate receptor 5 ligand 2-methyl-N-(6-methylp... 1 8
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 5-[5-chloro-... 2 18
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00280681 DNC009954 Investigative Drug 2-(1,4'-bipiperidin-1'-yl)thiazolo[4,5-b]pyridine
CFAMM00280680 DNC009955 Investigative Drug 2-(1,4'-bipiperidin-1'-yl)thiazolo[4,5-c]pyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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