CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2980
Family Name 5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine transporter Ligand 1-(2-phenoxyphenyl)piperazine Family
No. of Seeds 8 No. of Other Members 41
Family Centroid CFAMM00281070 Functional Category Investigative Drug
Superfamily 5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine transporter Binder Superfamily 2
Class Class 490

Cousin Family NamesSeedsMembers
Beta-2 adrenergic receptor Ligand Formoterol Family 16 63
Potassium voltage-gated channel subfamily H member 2 Ligand Do... 5 30
Acetylcholinesterase Inhibitor Edrophonium Family 7 40
Acetylcholinesterase Inhibitor Neostigmine Family 4 76
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
Calcium-activated potassium channel subunit alpha-1 Ligand Chl... 2 15
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 3 27
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 3 67
Substance-P receptor Ligand Ezlopitant Family 10 207
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
Transforming growth factor-beta Inhibitor ACE-011 Family 1 13
Dp-b99 family 1 5
Beta-2 adrenergic receptor Ligand Olodaterol Family 16 27
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 6 Ligand Sb 258585 Family 11 121
Histamine H3 receptor Ligand UCL1972 Family 3 23
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
5-hydroxytryptamine receptor 6 Ligand SB-357134 Family 13 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 20 33
Mineralocorticoid receptor and Androgen receptor Ligand AL-43 ... 79 235
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 20
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Liga... 40 90
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Cholesteryl ester transfer protein Inhibitor Tetrahydroquinoli... 3 8
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Fatty-acid amide hydrolase 1 Inhibitor 2-fluorophenyl 4-(octyl... 15 9
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Fatty-acid amide hydrolase 1 Inhibitor Phenmedipham Family 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 9
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 28 24
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Fatty-acid amide hydrolase 1 Inhibitor 4-nitrophenyl 4-benzylp... 5 35
D(4) dopamine receptor ligand AGN-PC-004XJQ family 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(4-... 3 5
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 2
Alpha-2A adrenergic receptor and 5-hydroxytryptamine receptor ... 7 10
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-3... 2 3
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 12 10
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 3
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
Survival motor neuron protein and DNA-(apurinic or apyrimidini... 1 5
Nischarin inhibitor SureCN7818902 family 2 12
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Sodium-dependent serotonin transporter inhibitor SureCN3890472... 2 0
5-hydroxytryptamine receptor 6 ligand 1-(4-methoxy-3-piperazin... 6 3
5-hydroxytryptamine receptor 6 ligand AGN-PC-0BRZ7B family 9 2
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 6 11
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 11 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 3 0
Gonadotropin-releasing hormone receptor ligand SureCN5756131 f... 5 7
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 1
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Neuropeptide Y receptor type 5 ligand 2-(7-chloro-3-oxo-1,4-be... 3 3
Neuropeptide Y receptor type 5 ligand N-[[4-[2-[7-(trifluorome... 1 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 5
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 16 6
Transient receptor potential cation channel subfamily V member... 1 0
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 2 3
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
Sodium-dependent serotonin transporter inhibitor 2-[2-[(dimeth... 3 3
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(2... 2 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 0
D(2) dopamine receptor and Muscarinic acetylcholine receptor M... 1 0
Translocator protein inhibitor [11C]DAA1106 family 15 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 3
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 10 1
C-C chemokine receptor type 1 ligand N-[2-[(2S)-3-(5-chlorospi... 4 0
C-C chemokine receptor type 1 ligand N-[2-[(2S)-2-amino-3-(5-f... 3 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 5 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 1
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 8
5-hydroxytryptamine receptor 7 ligand 1-(2-methoxyphenyl)-4-[2... 6 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 8
Poly [ADP-ribose] polymerase 1 inhibitor 6-[[4-(4-chlorophenyl... 1 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2
D(3) dopamine receptor and D(2) dopamine receptor ligand (5R)-... 2 0
Coagulation factor X and Cationic trypsin inhibitor 3-[(E)-3-[... 3 2
Glutamate receptor ionotropic, NMDA 2B and Potassium voltage-g... 2 1
Progesterone receptor ligand CHEMBL252850 family 2 0
Progesterone receptor ligand CHEMBL253735 family 2 0
Alpha-1D adrenergic receptor and D(2) dopamine receptor ligand... 3 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1A ligand AGN-PC-0034EG family 5 2
5-hydroxytryptamine receptor 1A ligand (1R,2R)-2-[4-(2,3-dihyd... 2 3
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 10
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Substance-P receptor ligand CP 141938 family 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand Desac... 2 3
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 1
Histamine H3 receptor ligand AGN-PC-077MDJ family 2 1
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 9 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 0
Peptide deformylase inhibitor (2S)-N-(cyclopropylmethyl)-N-[2-... 1 0
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 2 0
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 6
Arachidonate 5-lipoxygenase inhibitor ethyl (E)-3-(10H-phenoxa... 1 1
Leukotriene A-4 hydrolase inhibitor AGN-PC-087BON family 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-[2-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00281052 DNC010037 Investigative Drug 1-(2-(3-fluorophenoxy)phenyl)piperazine
CFAMM00281051 DNC010036 Investigative Drug 1-(2-(4-fluorophenoxy)phenyl)piperazine
CFAMM00281050 DNC010046 Investigative Drug 1-(2-(2-fluorobenzyloxy)phenyl)piperazine
CFAMM00281091 DNC011912 Investigative Drug 1-(2-Isopropoxy-phenyl)-piperazine
CFAMM00281070 DNC010054 Investigative Drug 1-(2-phenoxyphenyl)piperazine
CFAMM00281097 DNC011932 Investigative Drug 1-(2-Ethoxy-phenyl)-piperazine
CFAMM00281048 DNC010045 Investigative Drug 1-(2-(benzyloxy)phenyl)piperazine
CFAMM00281069 DNC011895 Investigative Drug 1-(2-Butoxy-phenyl)-piperazine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

23724 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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