CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2982
Family Name Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 6-methoxy-2-oxo-2h-chromene-3-carboxylic Acid Family
No. of Seeds 2 No. of Other Members 36
Family Centroid CFAMM00281106 Functional Category Investigative Drug with Natural Product
Superfamily Cyclooxygenase inhibitor salicylate derivative Aspirin Superfamily
Class Class 426

Cousin Family NamesSeedsMembers
Thyroid hormone receptor alpha ligand thyroid hormone analog L... 10 61
Lipoprotein lipase Inhibitor Gemfibrozil Family 1 28
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
Tyrosinase Inhibitor Monobenzone Family 6 197
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Ipriflavone family 62 2480
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Arachidonate 5-lipoxygenase Inhibitor Caffeic Acid Family 3 32
Proto-oncogene tyrosine-protein kinase Src Inhibitor Malonic A... 1 34
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU78300 F... 1 2
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Steryl-sulfatase Inhibitor Sulfamic Acid 2-nonyl-4-oxo-4h-chro... 4 68
Coagulation factor X and Prothrombin Inhibitor 3-chlorophenyl ... 2 12
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
NAD(P)H dehydrogenase [quinone] 1 Inhibitor NSC-106547 Family 3 65
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Kappa-type opioid receptor Ligand Anisocoumarin H Family 3 5
Androgen receptor Ligand 3-methoxy-4-(m-tolyloxy)benzonitrile ... 3 29
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Interleukin-8 Inhibitor 2-(2-(2-fluorophenoxy)phenyl)acetic Ac... 2 4
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
NAD(P)H dehydrogenase [quinone] 1 Inhibitor Ethyl Bis(4-hydrox... 5 7
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Amine oxidase [flavin-containing] B Inhibitor Methyl Piperate ... 1 19
Peroxisome proliferator-activated receptor delta ligand SureCN... 1 0
Histone deacetylase 2 and Histone deacetylase 8 inhibitor AC1L... 2 2
Histone deacetylase 2 and Histone deacetylase 8 inhibitor 2-hy... 1 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 10
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor (4-met... 1 1
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor propan... 3 5
NS5B protein inhibitor (Z)-4-[2-(3-cyanopropoxy)phenyl]-4-hydr... 2 0
Glutamate carboxypeptidase 2 inhibitor 2-phenylmethoxy-6-(2-su... 2 3
Carbonic anhydrase 9 and Carbonic anhydrase 12 inhibitor 5,10-... 1 0
Amine oxidase [flavin-containing] A inhibitor AGN-PC-02ON4B fa... 1 7
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 2 4
Phenylacetic Acid Derivatives Metabolite Guaicyl phenylacetate... 1 3
Putative NP ZINC31165975 Family 4 0
NP 4-(chloromethyl)-6-methoxy-2h-chromen-2-one Family 4 2
2-methyl-2H-chromene-3-carbaldehyde NP 2-methyl-2h-chromene-3-... 2 1
2-[(3,4-dimethoxyphenyl)methyl]propanedioate NP 4aji Family 1 0
2-[(E)-3-hydroxy-3-(6-methyl-2,4-dioxopyran-3-ylidene)prop-1-e... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00281114 DNC010069 Investigative Drug 8-methoxy-2-oxo-2H-chromene-3-carboxylic acid
CFAMM00281106 DNC010058 Investigative Drug 6-methoxy-2-oxo-2H-chromene-3-carboxylic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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