CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2983
Family Name D(2) dopamine receptor and D(3) dopamine receptor Ligand D-264 Family
No. of Seeds 6 No. of Other Members 32
Family Centroid CFAMM00281163 Functional Category Investigative Drug
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Ligand D-264 Superfamily
Class Class 1257

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
5-hydroxytryptamine receptor Ligand Sl65.0472 Family 2 16
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 7-me... 2 45
TGF-beta receptor type-1 Ligand 4-pyridin-2-yl-5-quinolin-4-yl... 4 23
Cathepsin B and Cathepsin K Inhibitor L-006235-1 Family 19 75
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
Metabotropic glutamate receptor 5 Ligand N-[4-(3-pyridylethyny... 2 10
C-C chemokine receptor type 4 Ligand N-(naphthalen-1-yl)-4-neo... 5 78
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 20 26
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Amine oxidase [flavin-containing] B Inhibitor 2-(2-cyclohexyli... 6 44
Histamine H3 receptor Ligand ST-1025 Family 2 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Reverse transcriptase Inhibitor 1-benzothiazol-2-yl-3-phenethy... 2 19
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-219... 2 0
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 2 7
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 20
Histone deacetylase 1 and Histone deacetylase 2 inhibitor AGN-... 2 5
Mitogen-activated protein kinase 14 inhibitor 4-[4-(4-fluoroph... 2 0
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 2 8
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Neuropeptide S receptor and Niemann-Pick C1 protein ligand CHE... 1 1
Amine oxidase [flavin-containing] B inhibitor 4-(4-fluoropheny... 3 4
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 3 7
Platelet-activating factor receptor ligand Foropafant family 2 0
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 8 6
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Amyloid beta A4 protein and Luciferin 4-monooxygenase inhibito... 11 46
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Microtubule-associated protein tau inhibitor 4-[(6-iodo-1,3-be... 1 1
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(4-phenyl-1,3-t... 3 4
Cathepsin K and Cathepsin L1 inhibitor (2R)-N-(cyanomethyl)-4-... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 6 5
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-N-[... 3 0
Cholinesterase and Acetylcholinesterase inhibitor 3-[ethyl-[3-... 6 9
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Sphingosine kinase 1 and Sphingosine kinase 2 inhibitor (2R,4S... 9 8
Histone deacetylase 1 inhibitor N',N'-bis[2-(1,3-benzothiazol-... 2 0
5-hydroxytryptamine receptor 1A and Alpha-2C adrenergic recept... 2 2
Neuropeptide Y receptor type 5 ligand 2-(dimethylamino)-1-[4-[... 10 5
Neuropeptide Y receptor type 5 ligand 1-[4-[[(9-fluoro-5,6-dih... 11 0
Amyloid beta A4 protein inhibitor SureCN2465837 family 4 2
Mitogen-activated protein kinase 14 inhibitor 303163-37-3 family 1 2
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck ligand... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor 4-[[4-(4-carb... 4 2
Vascular endothelial growth factor receptor 2 and Insulin rece... 2 0
D(2) dopamine receptor and Alpha-1A adrenergic receptor ligand... 1 0
Fructose-1,6-bisphosphatase 1 inhibitor AGN-PC-079IZF family 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00281174 CHEMBL467540 Bioactive AGN-PC-04SWTC
CFAMM00281165 CHEMBL468015 Bioactive AGN-PC-04SWGD
CFAMM00281177 CHEMBL456597 Bioactive (6S)-6-N-[2-(4-phenylpiperazin-1-yl)ethyl]-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
CFAMM00281144 CHEMBL171316 Bioactive AGN-PC-000QFY
CFAMM00281163 DNC010075 Investigative Drug D-264

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26821 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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