CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2984
Family Name D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237 Family
No. of Seeds 21 No. of Other Members 56
Family Centroid CFAMM00281223 Functional Category Investigative Drug
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237 Superfamily
Class Class 182

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Opioid receptor ligand opiate Levorphanol Family 18 537
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Acetylcholinesterase Inhibitor Edrophonium Family 7 40
Kappa-type opioid receptor Ligand Dezocine Family 36 46
D(2) dopamine receptor Ligand Quinagolide Family 2 0
Eptazocine Hbr family 6 8
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 3 27
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
D(2) dopamine receptor Ligand 2,3-dihydro-1h-indol-5-ol Family 1 4
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Amyloid beta A4 protein Inhibitor 4-(5-(4-(methylamino)phenyl)... 4 5
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 36 15
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 18 13
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(ethylamino)naphthal... 10 13
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 4
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-ch... 2 0
Kappa-type opioid receptor Ligand Morphinan Cyclic Imine Analo... 3 1
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00G... 16 4
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TF5... 1 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 6
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TFC... 2 7
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 5 29
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(4-... 3 5
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-01Z... 2 4
Alpha-2A adrenergic receptor and 5-hydroxytryptamine receptor ... 7 10
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 2
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 8 0
Estrogen receptor and Estrogen receptor beta ligand SureCN5681... 7 3
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
D(1A) dopamine receptor ligand (5S)-5-(4-azidophenyl)-8-iodo-3... 2 0
Sigma non-opioid intracellular receptor 1 ligand CHEMBL154452 ... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 2
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 11 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
Amyloid beta A4 protein inhibitor SureCN6372684 family 2 7
D(1A) dopamine receptor and D(2) dopamine receptor ligand AGN-... 1 3
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 0
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 3
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
5-hydroxytryptamine receptor 7 ligand 1-(2-methoxyphenyl)-4-[2... 6 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 1
Progesterone receptor ligand CHEMBL252850 family 2 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Substance-P receptor ligand CP 141938 family 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Estrogen receptor and Estrogen receptor beta ligand SureCN6716... 2 0
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(3-hydr... 1 0
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Histamine H3 receptor ligand SureCN3057839 family 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 6
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 2
Estrogen receptor beta and Estrogen receptor ligand (E)-3-[4-(... 1 0
Arachidonate 5-lipoxygenase inhibitor AGN-PC-0752DJ family 1 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 2 1
Benzazepines Metabolite 8-Hydroxyclomipramine Family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00281191 CHEMBL516296 Bioactive (4aS,10bS)-4-[2-(4-phenylpiperazin-1-yl)ethyl]-2,3,4a,5,6,10b-hexahydro-1H-benzo[f]quinolin-7-ol
CFAMM00281232 CHEMBL1254947 Bioactive AGN-PC-09M46O
CFAMM00281210 CHEMBL569003 Bioactive AGN-PC-07CQJJ
CFAMM00281230 CHEMBL254203 Bioactive 6-[4-(4-phenylpiperazin-1-yl)butyl-propylamino]-5,6,7,8-tetrahydronaphthalene-2,3-diol
CFAMM00281257 CHEMBL250552 Bioactive 6-[2-(4-phenylpiperazin-1-yl)ethyl-propylamino]-5,6,7,8-tetrahydronaphthalen-1-ol
CFAMM00281201 CHEMBL399164 Bioactive 6-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl-propylamino]-5,6,7,8-tetrahydronaphthalen-1-ol
CFAMM00281188 CHEMBL1253770 Bioactive AGN-PC-00RXES
CFAMM00281229 CHEMBL254202 Bioactive 6-[2-(4-phenylpiperazin-1-yl)ethyl-propylamino]-5,6,7,8-tetrahydronaphthalene-2,3-diol
CFAMM00281242 CHEMBL157293 Bioactive 7-[4-(4-phenylpiperazin-1-yl)butyl-prop-2-ynylamino]-5,6,7,8-tetrahydronaphthalen-2-ol
CFAMM00281222 CHEMBL315866 Bioactive AGN-PC-01RBPZ
CFAMM00281221 CHEMBL569747 Bioactive AGN-PC-07CQKC
CFAMM00281227 CHEMBL93391 Bioactive (E)-3-[4-(6-hydroxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)phenyl]-N,N-dimethylprop-2-enamide
CFAMM00281233 CHEMBL1254946 Bioactive AGN-PC-09M4YE
CFAMM00281224 DNC010079 Investigative Drug D-315
CFAMM00281223 DNC010077 Investigative Drug D-237

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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