CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2985
Family Name D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366 Family
No. of Seeds 5 No. of Other Members 75
Family Centroid CFAMM00281337 Functional Category Investigative Drug with Natural Product
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366 Superfamily
Class Class 2628

Cousin Family NamesSeedsMembers
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
Gonadotropin-releasing hormone receptor Ligand decapeptide ana... 9 162
Epidermal Growth Factor family 111 209
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Gastrin/cholecystokinin type B receptor ligand oligopeptide Ce... 35 209
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
DNA Binder Elliptinium Acetate Family 11 116
Growth hormone receptor Ligand EP-51216 Family 34 390
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
Eluxadoline family 4 85
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
DNA topoisomerase 1 Inhibitor KT6006 Family 3 53
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
Oestrogen receptor and Estrogen receptor beta Ligand ZK-119010... 2 16
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 50 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 36 15
Serine/threonine-protein kinase Chk1 and Wee1-like protein kin... 2 101
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3,3'-pyrazine-2,5-... 2 14
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35
Endothelin B receptor Ligand IRL-2500 Family 34 87
Androgen receptor Ligand 11-methyl-6,11-dihydro-5h-benzo[a]car... 7 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Phospholipase A2 Inhibitor Hyrtiosulawesine Family 1 3
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 6 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 3 28
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 5 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 13 2
Kinesin-like protein KIF11 inhibitor AGN-PC-080PZM family 1 11
Vascular endothelial growth factor receptor 2 ligand indolyl q... 4 3
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Renin inhibitor SureCN1144364 family 3 15
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Retinoic acid receptor alpha and Retinoic acid receptor beta l... 1 2
Presenilin-1 and Presenilin-2 inhibitor (2S)-3-(3,4-difluoroph... 1 0
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Gonadotropin-releasing hormone receptor ligand AGN-PC-075RJQ f... 3 0
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Protein kinase C alpha type and Protein kinase C delta type in... 4 37
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 3
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 17 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4S,... 5 2
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-0759OR family 4 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Histone deacetylase inhibitor (3S,6S,9S,12R)-3-[(2S)-butan-2-y... 1 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
NS5B protein inhibitor AC1O5AET family 3 1
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Coagulation factor VII inhibitor AGN-PC-0763KB family 1 1
Substance-P receptor ligand AGN-PC-01VLKE family 9 11
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 1 1
Transient receptor potential cation channel subfamily V member... 1 5
Beta-2 adrenergic receptor ligand SureCN5346426 family 8 0
Beta-2 adrenergic receptor ligand SureCN4598646 family 7 7
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
Wee1-like protein kinase and Serine/threonine-protein kinase C... 3 51
Wee1-like protein kinase and Serine/threonine-protein kinase C... 8 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 1
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Neutrophil collagenase and Stromelysin-1 inhibitor (3R)-N-hydr... 2 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Coagulation factor X and Urokinase-type plasminogen activator ... 8 10
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Endothelin B receptor and Endothelin-1 receptor ligand N-[(2R)... 12 3
Coagulation factor VII and Tissue factor inhibitor 2-[3-(5-car... 3 2
Coagulation factor X and Prothrombin inhibitor SureCN6434488 f... 3 13
Cannabinoid receptor 1 ligand (4-hydroxynaphthalen-1-yl)-[1-(2... 2 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
Cholecystokinin receptor type A ligand (4R)-5-(dipentylamino)-... 1 11
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
KiSS-1 receptor ligand N-[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-... 1 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 7 1
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 1 0
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 4 4
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aS... 2 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 1 0
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Mitogen-activated protein kinase 14 inhibitor AGN-PC-08866Z fa... 2 0
Glycogen phosphorylase, liver form inhibitor 5-chloro-N-(3,6,6... 5 9
Kinesin-like protein KIF11 inhibitor AGN-PC-07R5ZC family 1 5
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 48
Aldose reductase and Aldo-keto reductase family 1 member B10 i... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00281265 CHEMBL550089 Bioactive SureCN2699677
CFAMM00281275 CHEMBL551960 Bioactive SureCN2700849
CFAMM00281337 DNC010078 Investigative Drug D-366
CFAMM00281293 DNC013556 Investigative Drug H-Dmt-Tic-NH-CH2-Indl

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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