CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2987
Family Name Indoleamine 2,3-dioxygenase 1 Inhibitor 5-aminoquinolin-8-ol Family
No. of Seeds 3 No. of Other Members 16
Family Centroid CFAMM00281393 Functional Category Investigative Drug with Natural Product
Superfamily Cyclin-dependent kinase 4 and Indoleamine 2,3-dioxygenase 1 Binder Superfamily
Class Class 2071

Cousin Family NamesSeedsMembers
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Aromatic-L-amino-acid decarboxylase Inhibitor Vitamin B6 Family 6 13
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Food vacuoles Inhibitor Mefloquine Family 2 25
DNA Binder Elliptinium Acetate Family 11 116
Citric Acid family 2 58
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU79072 F... 1 2
Cytochrome b Inhibitor 2-nonyl-4-hydroxyquinoline N-OXIDE Family 2 22
Acetylcholinesterase Inhibitor Velnacrine Family 2 29
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
E3 ubiquitin-protein ligase Mdm2 Inhibitor NSC-66811 Family 4 27
Arachidonate 12-lipoxygenase, 12S-type Inhibitor NSC-125034 Fa... 1 0
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3,3'-pyrazine-2,5-... 2 14
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-m... 2 12
Kappa-type opioid receptor Ligand Clioquinol Family 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Metabotropic glutamate receptor 5 Ligand 3-hydroxy-5-(2-methyl... 2 1
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
D(4) dopamine receptor ligand AGN-PC-00SXAZ family 2 4
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 7 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 2 4
ATP-dependent molecular chaperone HSP82 and Arachidonate 12-li... 1 2
Nuclear receptor ROR-gamma and 4'-phosphopantetheinyl transfer... 2 0
Thioredoxin glutathione reductase and Nuclear receptor ROR-gam... 1 0
Reverse transcriptase/RNaseH inhibitor Uranidine family 1 0
2-[2-(4-hydroxyphenyl)ethyl]-6-methylpyridin-1-ium-3-ol NP 2-(... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00281393 DNC010091 Investigative Drug 5-aminoquinolin-8-ol
CFAMM00281391 DNC010094 Investigative Drug 5-(isopropylamino)quinolin-8-ol
CFAMM00281387 DNC010964 Investigative Drug OXYQUINOLINE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27276 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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