CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2993
Family Name Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl]piperazine Family
No. of Seeds 5 No. of Other Members 18
Family Centroid CFAMM00281499 Functional Category Investigative Drug with Natural Product
Superfamily 5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine transporter Binder Superfamily 2
Class Class 490

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Edrophonium Family 7 40
Acetylcholinesterase Inhibitor Neostigmine Family 4 76
Sodium channel protein type 10 subunit alpha and Sodium channe... 1 7
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
Cholesteryl ester transfer protein Inhibitor CP-800569 Family 5 81
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 3 67
Substance-P receptor Ligand Ezlopitant Family 10 207
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 6 Ligand Sb 258585 Family 11 121
Histamine H3 receptor Ligand UCL1972 Family 3 23
Peptidyl-prolyl cis-trans isomerase A Inhibitor 7-amino-4-meth... 4 59
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Carbonic anhydrase 2 Inhibitor 4-methoxyphenylsulfamide Family 2 27
Histone deacetylase 1 Inhibitor 7-(4-(dimethylamino)phenoxy)-n... 2 1
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 11 13
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Cholesteryl ester transfer protein Inhibitor Tetrahydroquinoli... 3 8
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Fatty-acid amide hydrolase 1 Inhibitor 2-fluorophenyl 4-(octyl... 15 9
Fatty-acid amide hydrolase 1 Inhibitor Propan-2-one O-4-(hexyl... 12 4
Fatty-acid amide hydrolase 1 Inhibitor Benzaldehyde O-4-ethoxy... 21 4
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Fatty-acid amide hydrolase 1 Inhibitor Phenmedipham Family 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 9
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Fatty-acid amide hydrolase 1 Inhibitor 4-nitrophenyl 4-benzylp... 5 35
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 4 6
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(4-... 3 5
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-087THW family 1 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN2729784 family 3 9
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Renin inhibitor 6-[[(2R)-1-[4-[3-[(2-methoxyphenyl)methoxy]pro... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Estrogen receptor and Estrogen receptor beta ligand SureCN5681... 7 3
Survival motor neuron protein and DNA-(apurinic or apyrimidini... 1 5
Acetylcholinesterase inhibitor trimethyl-(2-methyl-3-propanoyl... 3 2
Acetylcholinesterase inhibitor AGN-PC-075N8G family 2 9
Capsid scaffolding protein inhibitor AC1LAC6N family 2 1
Sodium-dependent serotonin transporter inhibitor SureCN3890472... 2 0
Survival motor neuron protein and ATP-dependent DNA helicase Q... 1 4
Substance-P receptor ligand (2S,4S)-1-N-(3-chlorophenyl)-2-N-[... 5 2
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Neuropeptide Y receptor type 5 ligand N-[[4-[2-[7-(trifluorome... 1 1
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Renin and Cytochrome P450 3A4 inhibitor SureCN6719989 family 2 0
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 2 3
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S)-4-(4-methoxya... 1 26
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
D(2) dopamine receptor and Muscarinic acetylcholine receptor M... 1 0
Translocator protein inhibitor [11C]DAA1106 family 15 2
Cathepsin S and Cathepsin K inhibitor SureCN3018173 family 2 4
Cathepsin K inhibitor (1R,2R)-N-(cyanomethyl)-2-[4-(3-methoxyp... 2 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 10 1
C-C chemokine receptor type 1 ligand N-[2-[(2S)-2-amino-3-(5-f... 3 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-[4-[3... 2 0
5-hydroxytryptamine receptor 7 ligand 1-(2-methoxyphenyl)-4-[2... 6 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-ethylbutanoyl)... 11 0
Coagulation factor X and Cationic trypsin inhibitor 3-[(E)-3-[... 3 2
Glutamate receptor ionotropic, NMDA 2B and Potassium voltage-g... 2 1
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 20 23
5-hydroxytryptamine receptor 1A ligand AGN-PC-0034EG family 5 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Neuropeptide Y receptor type 5 ligand 3-[4-(4-fluorophenoxy)ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Substance-P receptor ligand CP 141938 family 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 2
Neutrophil elastase inhibitor AGN-PC-04S1IE family 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 1 0
Acetylcholinesterase and Cholinesterase inhibitor [3-hydroxy-5... 2 4
Histamine H3 receptor ligand AGN-PC-077MDJ family 2 1
Amyloid beta A4 protein inhibitor 2-(fluoranylmethyl)-3-[4-[(E... 1 3
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 0
Peptide deformylase inhibitor (2S)-N-(cyclopropylmethyl)-N-[2-... 1 0
Hormone-sensitive lipase and Acetylcholinesterase inhibitor Su... 2 0
Prelamin-A/C and Nonstructural protein 1 inhibitor CHEMBL14536... 1 2
Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)... 4 16
Matrix metalloproteinase-9 and Metalloproteinase inhibitor 3 i... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00281498 DNC010111 Investigative Drug 1-(4-Phenoxyphenyl)piperazine
CFAMM00281499 DNC010110 Investigative Drug 1-[4-(4-Iodophenoxy)phenyl]piperazine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24328 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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