CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2995
Family Name Coagulation factor X and Prothrombin Inhibitor BMS-344577 Family
No. of Seeds 13 No. of Other Members 12
Family Centroid CFAMM00281528 Functional Category Investigative Drug
Superfamily Coagulation factor X and Prothrombin Binder Superfamily
Class Class 2604

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
SB1518 family 7 103
Coagulation factor X Inhibitor BMS-269223 Family 15 58
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 20 28
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 9 3
Ferritin light chain and Ras-related protein Rab-9A inhibitor ... 1 11
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
Histamine H3 receptor ligand N-[[2-[2-[(2R)-2-methylpyrrolidin... 7 2
Histamine H3 receptor ligand 4-[[2-[2-[(2R)-2-methylpyrrolidin... 1 0
Histamine H3 receptor ligand N-[2-[2-[(2R)-2-methylpyrrolidin-... 4 0
Coagulation factor X inhibitor (3S)-3-[[(Z)-1-[(2-methyl-1-ben... 1 0
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
CGMP-dependent protein kinase inhibitor AGN-PC-075IHL family 2 8
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-03J2ZU f... 1 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 19 2
NP N-(2-(3,4-dimethoxyphenyl)-4-oxo-4h-chromen-6-yl)nicotinami... 6 1
NP N-(2-(2-methoxyphenyl)-4-oxo-4h-chromen-6-yl)nicotinamide F... 9 0
carboxamide NP ZINC15729349 Family 2 0


External ID

Functional Category

Molecule Name

CFAMM00281534 CHEMBL197890 Bioactive N-[2-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]-1-benzofuran-5-yl]-5-(trifluoromethyl)pyridin-2-amine
CFAMM00281540 CHEMBL198703 Bioactive N-[2-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]-1-benzofuran-5-yl]pyrimidin-2-amine
CFAMM00281539 CHEMBL567048 Bioactive heteroaroylguanidine, 27
CFAMM00281532 CHEMBL199245 Bioactive N-[2-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]-1-benzofuran-5-yl]pyrimidin-5-amine
CFAMM00281545 CHEMBL364222 Bioactive 5-ethyl-N-[2-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]-1-benzofuran-5-yl]pyrimidin-2-amine
CFAMM00281531 CHEMBL565788 Bioactive isonicotinoyl guanidine, 23
CFAMM00281543 CHEMBL565390 Bioactive nicotinoyl guanidine, 31
CFAMM00281536 CHEMBL570639 Bioactive nicotinoyl guanidine, 33
CFAMM00281535 CHEMBL576094 Bioactive nicotinoyl guanidine, 35
CFAMM00281541 CHEMBL567487 Bioactive nicotinoyl guanidine, 32
CFAMM00281528 DNC010134 Investigative Drug BMS-344577

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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