CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2996
Family Name Angiotensin-converting enzyme and Endothelin-converting enzyme 1 Inhibitor SCH-54470 Family
No. of Seeds 2 No. of Other Members 10
Family Centroid CFAMM00281552 Functional Category Investigative Drug with Natural Product
Superfamily Bacterial outer membrane Inhibitor Daptomycin Superfamily
Class Class 647

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
HIV protease Inhibitor Indinavir Family 36 211
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
HIV-1 protease Inhibitor Atazanavir Family 16 58
Gastrin/cholecystokinin type B receptor ligand oligopeptide Ce... 35 209
Gamma-aminobutyric acid A receptor Ligand Bromazepam Family 2 60
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Fibroblast growth factor receptor 1 and Aurora kinase B Inhibi... 4 51
Substance-P receptor Ligand GSK424887 Family 8 184
Growth hormone receptor Ligand EP-51216 Family 34 390
CBP-501 family 7 8
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Lethal factor Inhibitor GM6001 Family 50 435
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Endothelin-converting enzyme 1 inhibitor 2-[[1-[[(2S)-4-methyl... 2 8
C-C chemokine receptor type 5 ligand AC1LAJEM family 4 14
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Cholecystokinin receptor type A ligand A-65186 family 2 6
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Cathepsin L1 inhibitor Bio2_000267 family 9 1
Neutrophil collagenase and Stromelysin-3 inhibitor AC1MORIH fa... 7 9
Integrin beta-3 and Integrin alpha-V inhibitor SureCN3888804 f... 11 13
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 0
Caspase-1 inhibitor (3S)-3-[[(2S)-4-[2-(1,2-dimethylindol-3-yl... 3 4
Caspase-1 inhibitor (3S)-4-oxo-3-[[(2S)-4-oxo-2-propan-2-yl-4-... 3 0
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
Renin inhibitor [(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydrox... 3 1
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 4 53
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 4
Disintegrin and metalloproteinase domain-containing protein 17... 3 3
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 0
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Prothrombin and Trypsin-1 inhibitor 1-[2-(4-benzylpiperidin-1-... 2 2
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[2-(1H-ind... 1 0
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Relaxin-3 receptor 1 and Relaxin-3 receptor 2 ligand CHEMBL203... 4 1
Prothrombin and Tissue-type plasminogen activator inhibitor 2-... 4 5
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Pancreatic alpha-amylase and Gastrin/cholecystokinin type B re... 7 1
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 4
C-C chemokine receptor type 2 ligand SureCN5946889 family 2 6
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 4
Renin inhibitor tert-butyl N-[1-[[1-[[1-cyclohexyl-4,4-difluor... 5 0
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2S,4R)... 2 2
Protein kinase C delta type and Protein kinase C beta type inh... 4 4
Endothelin B receptor and Endothelin-1 receptor ligand 2-[[(2R... 17 10
Neutrophil collagenase and Stromelysin-3 inhibitor [3-[[1-amin... 3 2
Growth factor receptor-bound protein 2 ligand 2-[4-[(2S)-3-[[1... 1 0
Gastrin/cholecystokinin type B receptor ligand (2R)-2-[[5-(8-a... 2 3
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Neprilysin and Endothelin-converting enzyme 1 inhibitor (2S)-2... 5 0
Endothelin-1 receptor and Endothelin B receptor ligand 2-[[(2R... 5 3
Neutrophil collagenase and Interstitial collagenase inhibitor ... 1 0
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
Stromelysin-3 and Neutrophil collagenase inhibitor AGN-PC-074N... 3 1
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 3 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 2 3
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 5 2
72 kDa type IV collagenase and Interstitial collagenase inhibi... 1 1
Angiotensin-converting enzyme inhibitor AC1L1IZN family 2 2
Angiotensin-converting enzyme and Endothelin-converting enzyme... 1 0
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 2 1
Interstitial collagenase and Stromelysin-1 inhibitor CHEMBL887... 1 0
A disintegrin and metalloproteinase with thrombospondin motifs... 2 12
Substance-P receptor ligand methyl 6-acetamido-3-[[(2S)-1-[[3,... 1 0
Neprilysin inhibitor AGN-PC-073PUZ family 1 0
Insulin receptor ligand 2,5-dihydroxy-3-(1H-indol-3-yl)-6-phen... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 48
Caspase-1 inhibitor (3S)-5-[2-(1H-indol-3-yl)acetyl]oxy-4-oxo-... 1 0
Calcium/calmodulin-dependent protein kinase type II subunit de... 1 0
5-(carbamoylamino)pentanoate NP ZINC12297125 Family 8 0
NP Agn-pc-099dao Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00281552 DNC010135 Investigative Drug SCH-54470

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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