CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3004
Family Name Tyrosine-protein phosphatase non-receptor type 1 Ligand Kuwanon J Family
No. of Seeds 3 No. of Other Members 3
Family Centroid CFAMM00281648 Functional Category Investigative Drug with Natural Product
Superfamily Danthron Superfamily
Class Class 779

Cousin Family NamesSeedsMembers
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor Mycophenola... 4 353
Estrogen receptor beta Ligand Conjugated Estrogens Family 12 210
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Ipriflavone family 62 2480
Rotenone family 16 107
Danthron family 11 141
taste receptor Ligand Cynarin Family 6 124
Agrimophol family 10 22
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Mitogen-activated protein kinase 12 Inhibitor SCIO-469 Family 1 7
Substance-P receptor Ligand CI-1021 Family 1 0
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Apoptosis regulator Bcl-2 Inhibitor Gossypol Family 1 9
Glucose-6-phosphate translocase Inhibitor Mumbaistatin Family 3 11
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 2 19
Steryl-sulfatase Inhibitor Sulfamic Acid 3-(4-hydroxy-benzoyl)... 3 2
Epidermal growth factor receptor Ligand AG-538 Family 5 11
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
Estrogen receptor beta Ligand 3,6-dihydroxy-2-(4-hydroxy-pheny... 2 23
Phospholipase A2 Inhibitor 3,9-dihydroxy-2,10-diprenylpterocap... 9 25
4-aminobutyrate aminotransferase, mitochondrial and Succinate-... 4 22
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
L-selectin and P-selectin Inhibitor 2,3,4-trihydroxybenzoic Ac... 2 10
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
DNA topoisomerase 2-beta Inhibitor Demethylzeylasterone Family 1 2
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 3 7
Indoleamine 2,3-dioxygenase 1 Inhibitor 2-hydroxygarvin A Family 2 2
Indoleamine 2,3-dioxygenase 1 Inhibitor Garveatin E Family 2 0
Histone deacetylase 1 Inhibitor Gymnochrome E Family 1 0
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 1 6
Arachidonate 5-lipoxygenase Inhibitor 4,5-dimethoxy-10h-anthra... 1 4
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Tyrosinase Inhibitor 3-(2,4-dihydroxyphenyl)-propionic Acid Et... 3 8
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 14
Protein kinase C beta type and Protein kinase C eta type inhib... 1 0
Thromboxane A2 receptor ligand AGN-PC-003UTI family 1 0
Acetylcholinesterase inhibitor 5,7-Dimethoxy-2-methyl-indan-1-... 1 0
Steryl-sulfatase inhibitor (8R,9S,13S,14S,17R)-17-benzyl-3,17-... 1 1
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 6 13
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 2
Catechol O-methyltransferase inhibitor 4,5-dihydroxybenzene-1,... 1 1
Sterol O-acyltransferase 1 and Sterol O-acyltransferase 2 inhi... 1 5
5-lipoxygenase inhibitor 6-(1,8-dihydroxy-9-oxo-10H-anthracen-... 6 0
Aldehyde dehydrogenase, cytosolic 1 and Aldehyde dehydrogenase... 2 0
Prenol Lipids Metabolite Scutigeral Family 1 0
Acenes Metabolite Lacinilene C Family 2 3
Prenol Lipids Metabolite Macrocarpal B Family 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00281648 DNC010150 Investigative Drug kuwanon J
CFAMM00281647 DNC010152 Investigative Drug kuwanon R
CFAMM00281646 DNC010154 Investigative Drug kuwanon V

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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