CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3011
Family Name Urotensin-2 receptor Ligand JNJ-28318706 Family
No. of Seeds 4 No. of Other Members 227
Family Centroid CFAMM00281788 Functional Category Investigative Drug with Natural Product
Superfamily cAMP-specific 3',5'-cyclic phosphodiesterase 4D Inhibitor Apremilast Superfamily
Class Class 1059

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Histamine H1 receptor Ligand Tranilast Family 5 125
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Inhibitor Apre... 1 4
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 16
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Potassium ... 1 15
Oxytocin receptor and Vasopressin V1a receptor Ligand L-371257... 8 92
MO15-related protein kinase Pfmrk Inhibitor 3-[3-(2-hydroxy-et... 1 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
Histamine H3 receptor Ligand A-349821 Family 49 228
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Mitogen-activated protein kinase 14 and Serine/threonine-prote... 1 1
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Multidrug resistance protein 1 and Multidrug resistance-associ... 3 55
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Amine oxidase [flavin-containing] A and Mitogen-activated prot... 1 71
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 8 39
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Integrin beta-1 and Integrin alpha-4 inhibitor (3S)-3-(3,4-dim... 5 61
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Cannabinoid receptor 2 ligand 8-butoxy-N-(2-fluoro-2-phenyleth... 12 7
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Rho-associated protein kinase 2 inhibitor N-(7-chloro-1-oxo-2H... 2 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand N-... 1 2
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Stromelysin-1 and 72 kDa type IV collagenase inhibitor [(2S)-2... 2 2
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
Poly [ADP-ribose] polymerase 1 inhibitor 6-[1-(2,3-dihydro-1,4... 1 30
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
C-C chemokine receptor type 3 ligand 1-(3-cyanophenyl)-3-[6-[[... 2 5
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-3... 2 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 7 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-087THY family 1 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 35
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 2
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Acrosin and Trypsin-1 inhibitor (4-methylphenyl) 4-(diaminomet... 10 13
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
Neuropeptide S receptor and Survival motor neuron protein liga... 1 2
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Trace amine-associated receptor 1 ligand EPPTB family 4 9
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Delta-type opioid receptor and Kappa-type opioid receptor liga... 15 6
Potassium voltage-gated channel subfamily H member 2 and Melan... 2 12
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-075FY0 f... 1 0
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X1U ... 2 3
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor ethyl ... 3 1
Microsomal triglyceride transfer protein large subunit inhibit... 3 0
Motilin receptor ligand SureCN14564469 family 1 6
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 2
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Somatostatin receptor type 1 and D(4) dopamine receptor ligand... 9 10
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 7 1
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 2
Delta-type opioid receptor and Kappa-type opioid receptor liga... 5 0
5-hydroxytryptamine receptor 1A ligand 3-hydroxy-6-iodo-2-[2-[... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 7
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 11 4
Substance-P receptor ligand AGN-PC-074DCO family 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 13
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 10 1
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(2,4-difl... 3 26
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Urotensin-2 receptor ligand SureCN2347581 family 10 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Retinoic acid receptor RXR-gamma and Retinoic acid receptor RX... 3 36
Multidrug resistance protein 1B and Multidrug resistance-assoc... 1 4
Nicotinamide phosphoribosyltransferase inhibitor N-(1,3-benzod... 1 0
Urotensin-2 receptor ligand SureCN1472946 family 2 0
Mitogen-activated protein kinase 14 inhibitor SureCN6679437 fa... 1 0
Multidrug resistance protein 1 inhibitor 3,4,5-trimethoxy-N-(2... 4 0
Angiotensin-converting enzyme inhibitor (6aS,8R)-8-hydroxy-5-[... 1 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 3
Coagulation factor X inhibitor 3,4-dimethoxy-N-[N-(4-methoxyph... 3 0
Histone deacetylase 1 and Histone deacetylase 2 inhibitor 4-[3... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
dimethyl 5-[[2-(3,4,7,8,9,10-hexahydro-2H-[1,4]dioxepino[2,3-g... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00281788 DNC010165 Investigative Drug JNJ-28318706

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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