CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3013
Family Name Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-trifluoropropoxy)nicotinamide Family
No. of Seeds 21 No. of Other Members 62
Family Centroid CFAMM00282128 Functional Category Investigative Drug
Superfamily Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-trifluoropropoxy)nicotinamide Superfamily
Class Class 1163

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Histamine H3 receptor Ligand GSK239512 Family 2 65
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Neuronal acetylcholine receptor subunit alpha-4 Ligand TC-5619... 3 61
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
DCC-2036 family 2 5
Smoothened homolog Inhibitor LDE225 Family 3 76
MK-6096 family 3 69
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Glucokinase Inhibitor GKA1 Family 2 67
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Cytochrome P450 3A4 Inhibitor 3-(5-((methylthio)methyl)furan-2... 4 14
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-[3... 1 2
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Reverse transcriptase/RNaseH inhibitor AC1LALKM family 2 19
Neutrophil elastase inhibitor phenyl N-[(2S)-1-[(2S)-2-[[(3S)-... 2 0
C-C chemokine receptor type 5 ligand (2,4-dimethyl-1-oxidopyri... 5 4
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor AGN-PC... 1 2
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
Gonadotropin-releasing hormone receptor ligand 1-[(2,6-difluor... 6 31
Lanosterol synthase inhibitor (4-bromophenyl)-[6-[6-[methyl(pr... 1 1
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 5 2
Histamine H3 receptor ligand SureCN3057575 family 4 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 2
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 1 0
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Somatostatin receptor type 5 ligand AGN-PC-088VSK family 2 3
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Renin inhibitor AGN-PC-09M9MJ family 2 23
Sodium channel protein type 10 subunit alpha and Sodium channe... 1 1
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Vascular endothelial growth factor receptor 2 ligand AC1LMMCZ ... 1 0
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Cathepsin S and Cathepsin K inhibitor N-[(2S)-3-(1-methylcyclo... 2 0
Cytochrome P450 2C19 and Inositol monophosphatase 1 inhibitor ... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Renin inhibitor [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrr... 5 12
Histamine H3 receptor ligand 3-[4-[3-[(2R)-2-methylpyrrolidin-... 1 5
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 11
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 10 15
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 7
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 1 13
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 2
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... 7 3
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Growth hormone secretagogue receptor type 1 and Potassium volt... 3 0
Growth hormone secretagogue receptor type 1 and Potassium volt... 2 0
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 3 0
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Beta-1 adrenergic receptor ligand N-[2-[[(2S)-3-(2-cyanophenox... 2 1
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-4-[[(4S)... 34 23
Histamine H3 receptor ligand 6-[[2-[2-[(2R)-2-methylpyrrolidin... 2 0
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 1 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
G-protein coupled bile acid receptor 1 ligand (4-cyclopropyl-2... 10 13
G-protein coupled bile acid receptor 1 ligand (4-cyclopropyl-2... 2 1
Beta-secretase 1 and Cytochrome P450 3A4 inhibitor N-[(2S,3R)-... 3 7
Motilin receptor ligand SureCN2768193 family 2 1
Motilin receptor ligand SureCN2765637 family 1 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Prothrombin and Coagulation factor X inhibitor N-[3-[(3-fluoro... 1 8
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5532501 fa... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Vascular endothelial growth factor receptor 2 and Vascular end... 2 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
CGMP-dependent protein kinase inhibitor AGN-PC-075IHL family 2 8
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
72 kDa type IV collagenase and Aminopeptidase N inhibitor ly52... 1 0
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 1 2
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 2 2
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 6 1
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN5948146 family 1 4
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 4
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 5 1
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 2 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 3
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 1 0
Sodium channel protein type 9 subunit alpha and Potassium volt... 1 1
Dual specificity mitogen-activated protein kinase kinase 1 inh... 1 2
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 1 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Reverse transcriptase/RNaseH inhibitor 3Am-6Et-7,9-diMe-PBOA-5... 4 1
Reverse transcriptase/RNaseH inhibitor 7CN-6Et-9Me-PBOA-5one f... 4 1
Coagulation factor X inhibitor 3-Oxybenzamide 15 family 1 1
Neutrophil elastase inhibitor SureCN8210283 family 2 2
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6
Fatty-acid amide hydrolase 1 and Monoglyceride lipase inhibito... 1 3
Platelet-activating factor receptor ligand AGN-PC-001U4L family 2 0
NP N-(2-(2-methoxyphenyl)-4-oxo-4h-chromen-6-yl)nicotinamide F... 9 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00282110 CHEMBL564893 Bioactive SureCN5947658
CFAMM00282130 CHEMBL1170999 Bioactive SureCN525037
CFAMM00282143 CHEMBL572205 Bioactive AGN-PC-014VSK
CFAMM00282174 CHEMBL556234 Bioactive AGN-PC-076IP5
CFAMM00282173 CHEMBL567314 Bioactive AGN-PC-07CRL9
CFAMM00282091 CHEMBL566648 Bioactive AGN-PC-07CRLG
CFAMM00282134 CHEMBL2364298 Bioactive SureCN2765921
CFAMM00282166 CHEMBL2364318 Bioactive SureCN2767069
CFAMM00282172 CHEMBL1170790 Bioactive SureCN2976982
CFAMM00282106 CHEMBL1171757 Bioactive SureCN524373
CFAMM00282133 CHEMBL2364291 Bioactive SureCN2766433
CFAMM00282149 CHEMBL567703 Bioactive AGN-PC-07CRLN
CFAMM00282165 CHEMBL1171754 Bioactive SureCN524288
CFAMM00282105 CHEMBL567110 Bioactive AGN-PC-07CRL8
CFAMM00282164 CHEMBL565628 Bioactive AGN-PC-07CRKA
CFAMM00282156 CHEMBL1270208 Bioactive AGN-PC-00RYTX
CFAMM00282131 CHEMBL1170788 Bioactive SureCN2965073
CFAMM00282128 DNC010180 Investigative Drug N-benzyl-6-(3,3,3-trifluoropropoxy)nicotinamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27056 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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