CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3015
Family Name Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dichlorobenzyl)nicotinamide Family
No. of Seeds 10 No. of Other Members 116
Family Centroid CFAMM00282205 Functional Category Investigative Drug
Superfamily Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dichlorobenzyl)nicotinamide Superfamily
Class Class 11

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Transient receptor potential cation channel subfamily V member... 16 295
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
ABC294640 family 5 75
Casein kinase II subunit alpha Inhibitor CX-4945 Family 1 7
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
Stress kinase p38 Inhibitor P38 Map Kinase Inhibitor Family 1 3
XL-888 family 16 85
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Class II cytokine receptor Ligand IL-10 Family 7 45
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Tubulin beta chain Inhibitor 2-(3-chloro-phenyl)-1h-[1,8]napht... 3 13
Tubulin beta chain Inhibitor 7-methyl-2-m-tolyl-1h-[1,8]naphth... 7 15
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Metabotropic glutamate receptor 5 Ligand 3-chloro-n-(6-chlorop... 2 5
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Peroxisome proliferator-activated receptor gamma Ligand 2-chlo... 5 19
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
Amine oxidase [flavin-containing] A Inhibitor 6-chloro-n-(2-mo... 5 3
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Tubulin beta chain Inhibitor 2-m-tolyl-1h-[1,8]naphthyridin-4-... 5 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 6-(4-... 3 6
Reverse transcriptase/RNaseH inhibitor AC1LAJTF family 6 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
5-hydroxytryptamine receptor 1A and D(1A) dopamine receptor li... 2 3
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
ALK tyrosine kinase receptor ligand SureCN1600195 family 1 1
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Coagulation factor X inhibitor (3R,4R)-3-N-(5-chloropyridin-2-... 3 6
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Nicotinamide phosphoribosyltransferase inhibitor 4-[(7-chloro-... 6 4
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-ami... 2 0
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 2 7
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 2
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Cellular tumor antigen p53 inhibitor CHEMBL1551403 family 1 0
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Coagulation factor X and Kallikrein-1 inhibitor SureCN890858 f... 5 6
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Coagulation factor X inhibitor AGN-PC-078Y3A family 4 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 13 3
Nicotinamide phosphoribosyltransferase inhibitor 4-[[(7-chloro... 1 1
Metabotropic glutamate receptor 5 ligand SureCN3866791 family 2 10
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
B1 bradykinin receptor ligand 6-(8-fluoro-4-methyl-1-oxophthal... 3 0
G1/S-specific cyclin-E2 and G1/S-specific cyclin-E1 inhibitor ... 5 10
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 2-... 3 0
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 3 6
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
C-X-C chemokine receptor type 3 ligand 3-amino-6-chloro-5-[(3S... 11 1
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(2-amino-6... 13 0
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(4-chlorob... 6 0
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X3N ... 1 7
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Cell division cycle 7-related protein kinase and Dual specific... 3 1
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 1 1
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
B1 bradykinin receptor ligand methyl 2-fluoro-6-[3-fluoro-4-[[... 22 11
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Corticotropin-releasing factor receptor 1 ligand 4-[(1R)-1-cyc... 5 6
Substance-P receptor ligand Netupitant family 5 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
Dipeptidyl peptidase 4 inhibitor 7-amino-6-(aminomethyl)-5-(2-... 1 6
Dipeptidyl peptidase 4 inhibitor 6-(aminomethyl)-5-(2-bromo-5-... 6 1
Smoothened homolog inhibitor 3-pyridin-3-yl-N-[1-[[6-[4-[(3-py... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Aurora kinase A inhibitor Bisanilinopyrimidine, 6j family 2 1
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 0
ALK tyrosine kinase receptor ligand N-[6-[[4-(2-hydroxypropan-... 2 0
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 2 11
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 6 3
P2X purinoceptor 7 inhibitor SureCN1635928 family 4 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
Tyrosine-protein kinase receptor TYRO3 and P-selectin ligand 2... 2 3
Tyrosine-protein kinase receptor TYRO3 and Mitogen-activated p... 3 7
Metabotropic glutamate receptor 5 ligand 5-(4-chlorophenyl)-1,... 3 1
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0Z0U... 2 0
Non-receptor tyrosine-protein kinase TYK2 ligand SureCN1298914... 3 0
Non-receptor tyrosine-protein kinase TYK2 ligand SureCN3514789... 1 0
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 7 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 17 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Coagulation factor X inhibitor 5-bromo-N-(5-chloropyridin-2-yl... 1 1
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Thromboxane-A synthase inhibitor 6-chloro-3-(4-imidazol-1-ylbu... 12 21
Substance-K receptor and Substance-P receptor ligand 3,5-dichl... 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Coagulation factor X inhibitor N-[2-[(5-chloropyridin-2-yl)sul... 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Cannabinoid receptor 2 ligand N-isoquinolin-1-yl-4-methyl-3-pi... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 4
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Macrophage colony-stimulating factor 1 receptor ligand N-[3-[(... 5 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 0
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Transient receptor potential cation channel subfamily V member... 3 2
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 4 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 1 0
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 0
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Sonic hedgehog protein and Cytochrome P450 2C9 inhibitor AGN-P... 1 0
C-C chemokine receptor type 5 ligand AC1MHPAK family 5 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(2,6... 1 1
Reverse transcriptase/RNaseH inhibitor PETT deriv. 13 family 1 0
Transcription factor AP-1 and Nuclear factor NF-kappa-B p105 s... 2 4
Cannabinoid receptor 2 ligand SureCN13503317 family 7 7
Tyrosine-protein kinase receptor TYRO3 and Tyrosine-protein ki... 1 0
Amine oxidase [flavin-containing] B and Metabotropic glutamate... 2 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 1 0
Histone deacetylase 1 inhibitor SureCN4538615 family 2 2
C-C chemokine receptor type 3 ligand 4-[[2-(4-chlorophenyl)eth... 2 1
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 1
Transient receptor potential cation channel subfamily V member... 2 0
P2X purinoceptor 7 inhibitor 1-[3-[4-chloro-3-(cycloheptylmeth... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [2-(a... 1 2
Potassium voltage-gated channel subfamily KQT member 3 and Pot... 2 0
C-X-C chemokine receptor type 2 ligand 6-chloro-N-(4-fluorophe... 1 0
Reverse transcriptase/RNaseH inhibitor 133626-85-4 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00282287 CHEMBL1681868 Bioactive SureCN13205694
CFAMM00282301 CHEMBL250684 Bioactive AGN-PC-03MSWD
CFAMM00282314 CHEMBL2387132 Bioactive SureCN3514252
CFAMM00282307 CHEMBL250228 Bioactive SureCN429452
CFAMM00282313 CHEMBL472288 Bioactive SureCN13205647
CFAMM00282268 CHEMBL401153 Bioactive SureCN427506
CFAMM00282303 CHEMBL1681869 Bioactive SureCN13205719
CFAMM00282244 DNC010271 Investigative Drug 6-(4-chlorophenylamino)-N,N-diethylnicotinamide
CFAMM00282205 DNC010182 Investigative Drug 6-amino-N-(2,4-dichlorobenzyl)nicotinamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26200 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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