CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3030
Family Name Kappa-type opioid receptor and Mu-type opioid receptor Ligand 2-(2-methylquinolin-4-ylamino)-n-phenylacetamide Family
No. of Seeds 19 No. of Other Members 108
Family Centroid CFAMM00282586 Functional Category Investigative Drug with Natural Product
Superfamily Kappa-type opioid receptor and Mu-type opioid receptor Ligand 2-(2-methylquinolin-4-ylamino)-n-phenylacetamide Superfamily
Class Class 1105

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
HIV protease Inhibitor Saquinavir Family 64 428
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Neuronal acetylcholine receptor subunit alpha-4 Ligand Varenic... 3 54
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Gamma-aminobutyric acid A receptor Ligand Bromazepam Family 2 60
Histamine H1 receptor Ligand Triprolidine Family 19 316
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
26S proteasome Inhibitor Bortezomib Family 7 65
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
Prothrombin Inhibitor Ximelegatran Family 8 157
Transient receptor potential cation channel subfamily V member... 15 158
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Substance-P receptor Ligand GSK424887 Family 8 184
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Glucagon receptor Ligand Dwlip-gcgrrx Family 5 26
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
Amg 423 family 7 47
Setipiprant family 5 118
ABC294640 family 5 75
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
CP-18770 family 6 27
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Cyclin-dependent kinase 5 Inhibitor 9-nitropaullone Family 2 13
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Dihydroorotate dehydrogenase Inhibitor Nsc 665564 Family 2 83
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Lethal factor Inhibitor N,n'-bis(4-amino-2-methylquinolin-6-yl... 2 11
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Fatty acid-binding protein, adipocyte and Fatty acid-binding p... 3 11
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 43 17
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Poly [ADP-ribose] polymerase 1 Inhibitor 2-ethylquinoline-8-ca... 3 4
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Mineralocorticoid receptor and Androgen receptor Ligand WAY-25... 10 26
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 4 33
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Urotensin-2 receptor Ligand Palosuran Family 4 4
Kinesin-like protein KIF11 Inhibitor 2-(trifluoromethyl)-9h-ca... 5 0
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Adenosine receptor A3 and Potassium voltage-gated channel subf... 1 18
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 10 18
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 1 Ligand N-(2-phenylpropyl)qui... 3 1
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0
Metabotropic glutamate receptor 1 Ligand (e)-4,4-dimethyl-1-qu... 2 2
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... 1 0
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 3
Epidermal growth factor receptor ligand AGN-PC-07Q1HU family 4 17
Calcitonin gene-related peptide type 1 receptor ligand CHEMBL1... 5 8
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YYL... 1 3
Caspase-1 inhibitor (3S)-3-[[(2S)-4-[2-(1,2-dimethylindol-3-yl... 3 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Serine/threonine-protein kinase mTOR and DNA-dependent protein... 6 7
Cathepsin K and Potassium voltage-gated channel subfamily H me... 5 1
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 13 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-08W6BO ... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-072CVE ... 4 4
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Glucosylceramidase and Alpha-galactosidase A inhibitor AC1NNEG... 4 5
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Dipeptidyl peptidase 4 inhibitor (2S)-1-[2-[5-(aminomethyl)-2-... 4 4
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 2 3
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 4 2
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 2
Hepatocyte growth factor receptor ligand AGN-PC-08XYH0 family 8 4
Hepatocyte growth factor receptor ligand AGN-PC-08XYH3 family 1 0
Hepatocyte growth factor receptor ligand AGN-PC-09M1N4 family 2 0
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
C-X-C chemokine receptor type 3 ligand (6aR,9R)-N-phenyl-4-(2-... 5 0
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Cannabinoid receptor 2 ligand 1-[[4-[5-fluoro-6-(piperidin-1-y... 21 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 7 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 5 6
Melanin-concentrating hormone receptor 2 ligand N,N-dimethyl-3... 2 2
Melanin-concentrating hormone receptor 2 ligand N-[(1R)-1'-(9H... 4 1
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... 1 7
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 0
Melanin-concentrating hormone receptor 1 ligand SureCN4261878 ... 4 7
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 5 8
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 2
Melanin-concentrating hormone receptor 1 ligand SureCN6198980 ... 13 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Prostaglandin D2 receptor 2 ligand 2-[(3R)-3-(3,3-diphenylprop... 1 0
Neuromedin-K receptor and Potassium voltage-gated channel subf... 13 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 3 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Motilin receptor ligand SureCN2768052 family 3 0
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 7 7
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 18
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 5
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 8
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
Cholinesterase and Acetylcholinesterase inhibitor [2,2-dimethy... 2 0
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
5-hydroxytryptamine receptor 5A and 5-hydroxytryptamine recept... 2 0
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
Stromelysin-3 and Neutrophil collagenase inhibitor AGN-PC-074N... 3 1
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Histone deacetylase 1 inhibitor AGN-PC-0456JP family 1 0
Telomerase reverse transcriptase inhibitor N-[9-(4-aminoanilin... 1 11
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 5 2
Melanin-concentrating hormone receptor 1 ligand SureCN6200892 ... 1 0
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 1 0
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
Plasmepsin-2 and Cathepsin D inhibitor N'-(3,4-dimethylacridin... 1 0
Coagulation factor X and Prothrombin inhibitor N,1-bis[(3-carb... 1 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 5
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
P2X purinoceptor 7 inhibitor N'-quinolin-5-yladamantane-1-carb... 2 9
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
P2Y purinoceptor 12 inhibitor (4S)-4-[(4,6-diphenylpyridine-2-... 1 0
Dihydrofolate reductase inhibitor N-(2,4-diamino-5-methylquina... 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 1
Potassium voltage-gated channel subfamily A member 5 and Volta... 2 4
D(4) dopamine receptor ligand SureCN4006627 family 1 0
P2X purinoceptor 7 inhibitor SureCN1194877 family 1 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Interstitial collagenase and Matrix metalloproteinase-9 inhibi... 1 5
Neutrophil collagenase and Stromelysin-1 inhibitor (3R)-N-hydr... 1 6
Endothelin-converting enzyme 1 inhibitor 5-(3,3-dimethylbutano... 1 1
Nuclear receptor ROR-gamma and Prelamin-A/C ligand CHEMBL14461... 1 18
Nonstructural protein 1 and Lysine-specific demethylase 4E inh... 1 0
Hexokinase and Farnesyl pyrophosphate synthase inhibitor AC1NQ... 1 0
Beta-secretase 1 and Cathepsin D inhibitor 2-[2-(1-adamantyl)-... 11 0
Acetylcholinesterase inhibitor (9R)-11-amino-6,6,9-trimethyl-9... 1 0
12b-methyl-2,3,6,7-tetrahydropyrazino[1',2':1,2]pyrido[3,4-b]i... 11 0
12b-methyl-2,3,6,7-tetrahydropyrazino[1',2':1,2]pyrido[3,4-b]i... 16 0
(S)-2-amino-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4... 1 0
2,3,6,7-tetrahydropyrazino[1',2':1,2]pyrido[3,4-b]indole-1,4(1... 3 0
(4aR,13bS,14aR)-3,4,4a,5,7,8,13,13b,14,14a-decahydro-5,14-etha... 2 0
6-(3-nitrophenyl)-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyri... 16 0
8'-fluoro-6'-methyl-2,3,4,5',6',9-hexahydrodispiro[beta-carbol... 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00282599 CHEMBL1808473 Bioactive 4-[3-(aminomethyl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]piperazin-2-one
CFAMM00282557 CHEMBL1631539 Bioactive SureCN2895887
CFAMM00282591 CHEMBL440983 Bioactive N,N'-bis[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]oxamide
CFAMM00282581 CHEMBL1632209 Bioactive SureCN2881638
CFAMM00282603 CHEMBL451304 Bioactive (2S)-1-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]-N-[5-(1,2,3,4-tetrahydroacridin-9-ylamino)pentyl]pyrrolidine-2-carboxamide
CFAMM00282568 CHEMBL2064471 Bioactive 3-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethylamino]-1-[4-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]piperazin-1-yl]propan-1-one
CFAMM00282549 CHEMBL1672113 Bioactive AGN-PC-09QMDR
CFAMM00282512 CHEMBL217061 Bioactive SureCN6203219
CFAMM00282614 CHEMBL1632207 Bioactive SureCN2882750
CFAMM00282493 CHEMBL58424 Bioactive SureCN1594107
CFAMM00282600 CHEMBL1808474 Bioactive 1-[3-(aminomethyl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]piperazine-2,3-dione
CFAMM00282619 CHEMBL1632208 Bioactive SureCN2883685
CFAMM00282586 DNC010242 Investigative Drug 2-(2-methylquinolin-4-ylamino)-N-phenylacetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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