CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3048
Family Name Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)-5-amino-3-(4-methoxybenzylidene)indolin-2-one Family
No. of Seeds 1 No. of Other Members 60
Family Centroid CFAMM00283095 Functional Category Investigative Drug with Natural Product
Superfamily Histone deacetylase 2 and Metabotropic glutamate receptor 5 Binder Superfamily
Class Class 281

Cousin Family NamesSeedsMembers
Beta-1 adrenergic receptor Ligand Acebutolol Family 2 27
Sodium channel protein type 5 subunit alpha Ligand Proparacain... 2 26
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Histamine H1 receptor Ligand Tranilast Family 5 125
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Receptor tyrosine-protein kinase erbB-2 Inhibitor Mini-antibod... 1 0
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Potassium ... 1 15
Oxytocin receptor and Vasopressin V1a receptor Ligand L-371257... 8 92
MO15-related protein kinase Pfmrk Inhibitor 3-[3-(2-hydroxy-et... 1 6
Cytochrome P450 1B1 Inhibitor N-(2,4-dimethoxy-phenyl)-3,5-dim... 1 110
High affinity nerve growth factor receptor and RAF proto-oncog... 3 29
Substance-K receptor Ligand MEN-14933 Family 13 154
Mitogen-activated protein kinase 14 and Serine/threonine-prote... 1 1
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Oxysterols receptor LXR-alpha Ligand N-{4-[2-(4-methoxyphenyl)... 3 16
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 7 18
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Fatty-acid amide hydrolase 1 Inhibitor Phenylcarbamic Acid Bip... 3 7
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Histone deacetylase 2 Inhibitor N-(2-amino-5-(furan-2-yl)pheny... 3 7
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxy-phenyl)-... 1 3
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 16
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-(4... 2 6
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Metabotropic glutamate receptor 5 Ligand N-(3-(3-cyanobenzamid... 2 13
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Gamma-aminobutyric acid receptor Ligand 2-(2-amino-phenyl)-6-m... 4 23
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-02INEQ... 6 6
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 6 11
Trace amine-associated receptor 1 ligand EPPTB family 4 9
Histamine H3 receptor ligand SureCN2785624 family 2 0
Prostaglandin D2 receptor 2 ligand 2-[4-methoxy-3-[2-[[(1S)-1-... 5 28
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 1 2
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor ethyl ... 3 1
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 3 3
Mitogen-activated protein kinase 14 inhibitor Skepinone-L family 11 31
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 6 3
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
Receptor-type tyrosine-protein kinase FLT3 ligand (3Z)-5-chlor... 1 4
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
Adenosine receptor A3 and Adenosine receptor A1 ligand 4-metho... 3 1
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-(3-methoxy-2-me... 2 4
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 13
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 2
Lanosterol synthase inhibitor AGN-PC-07BZTC family 1 3
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 0
Trace amine-associated receptor 1 ligand ZINC07609882 family 2 0
Leukotriene B4 receptor 1 ligand 4-methoxy-3-[[(E)-3-(4-phenyl... 2 10
Amine oxidase [flavin-containing] B and Adenosine receptor A2b... 2 2
Caspase-3 inhibitor AGN-PC-00ELYM family 3 2
Inosine-5'-monophosphate dehydrogenase 2 inhibitor SureCN32423... 1 0
Adenosine receptor A3 ligand N-(4-methoxyphenyl)-2-oxo-1H-quin... 1 2
Dual specificity mitogen-activated protein kinase kinase 1 inh... 9 1
Acyl-CoA:cholesterol acyltransferase and Sterol O-acyltransfer... 1 0
Thioredoxin glutathione reductase and Microtubule-associated p... 1 2
Major prion protein and Microtubule-associated protein tau inh... 2 10
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 0
Cytochrome P450 2D6 inhibitor 2-[(3-butoxyphenoxy)methyl]-3-me... 1 0
Multidrug resistance protein 1 inhibitor 3,4,5-trimethoxy-N-(2... 4 0
Aldo-keto reductase family 1 member C3 and Aldo-keto reductase... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 3
Tubulin beta-2B chain and Similar to alpha-tubulin isoform 1 i... 1 1
Nuclear receptor ROR-gamma and Lethal factor ligand NSC211094 ... 1 3
ATP-sensitive inward rectifier potassium channel 11 ligand AGN... 2 0
Histone deacetylase 1 and Histone deacetylase 2 inhibitor 4-[3... 4 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
Beta-lactamase and Microtubule-associated protein tau inhibito... 1 1
NP (s)-3-(2,5-dioxo-2,3,4,5-tetrahydro-1h-benzo[e][1,4]diazepi... 3 0
N-(4-acetamidophenyl)-2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)... 1 0
4-(4-methoxyphenyl)-2,4,5,10-tetrahydro-1H-pyrrolo[3,4-c][1,5]... 4 0
3-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-1H-indol-2-one ... 3 1
methyl 2-[(7-bromo-1-benzoxepine-4-carbonyl)amino]benzoate NP ... 1 0
Putative NP ZINC04043041 Family 4 1
3-[(3-amino-4-methoxybenzoyl)amino]propanoate NP Agn-pc-09e1h5... 1 1
3,5-bis[[2-(4-methoxyphenoxy)acetyl]amino]benzoate NP Agn-pc-0... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00283095 DNC010329 Investigative Drug (Z)-5-Amino-3-(4-methoxybenzylidene)indolin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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