CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3071
Family Name Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybenzylcarbamate Family
No. of Seeds 10 No. of Other Members 5
Family Centroid CFAMM00283472 Functional Category Investigative Drug
Superfamily Amyloid beta A4 protein Inhibitor Florbetapir F-18 Superfamily
Class Class 796

Cousin Family NamesSeedsMembers
Peroxisome proliferator-activated receptor gamma Ligand Piogli... 2 29
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Acetylcholinesterase Inhibitor Pyridostigmine Family 5 197
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Histamine H1 receptor Ligand Doxylamine Family 2 91
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 3 24
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(4-f... 2 5
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Neuronal acetylcholine receptor subunit beta-2 Ligand ABT-594 ... 4 5
Transient receptor potential cation channel subfamily V member... 2 12
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Translocator protein inhibitor SureCN13502542 family 20 2
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 8 8
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 6 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(2-methoxy-3-methylpy... 2 3
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 6 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
Histamine H3 receptor and D(3) dopamine receptor ligand BODILI... 1 0
P2Y purinoceptor 1 inhibitor 1-(4-tert-butylphenyl)-3-[2-(2-pr... 4 14
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Transient receptor potential cation channel subfamily V member... 6 1
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 2
Disintegrin and metalloproteinase domain-containing protein 17... 1 0
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 2
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
Pol polyprotein inhibitor N-benzyl-2,2-difluoro-4-[[(2S)-3-met... 1 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 6 0
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
Glutamate receptor ionotropic, NMDA 2B and Cytochrome P450 2D6... 2 3
Cytochrome P450 1A2 inhibitor 1-[3-[(3R)-1-(dimethylsulfamoyl)... 1 0
Lysophosphatidic acid receptor 1 and Lysophosphatidic acid rec... 3 6
Transient receptor potential cation channel subfamily V member... 3 2
Farnesyl pyrophosphate synthase inhibitor [phosphono-[[4-(4-pr... 6 0
Histone deacetylase 1 inhibitor 7-[3-fluoro-4-[[3-hydroxy-5-(h... 2 1
Hormone-sensitive lipase inhibitor AGN-PC-046LTD family 3 8
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 2
Muscleblind-like protein 1 and Lysosomal alpha-glucosidase inh... 2 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
Glutamate receptor ionotropic, NMDA 2B ligand AGN-PC-0A9UZU fa... 3 0
Butyrylcholinesterase and Muscarinic acetylcholine receptor M2... 1 0
Pol polyprotein inhibitor tert-butyl N-[(2S,3R)-3-hydroxy-4-[[... 1 1
3-(4-methoxyphenyl)-1-pyrrol-1-ylpropan-1-one NP Agn-pc-08zsfd... 1 1
4-methyl-7-(pyridin-3-ylmethylideneamino)chromen-2-one NP (e)-... 1 0
(4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00283467 CHEMBL597940 Bioactive [(E)-pyridin-3-ylmethylideneamino] N-(4-dodecoxyphenyl)carbamate
CFAMM00283475 CHEMBL598556 Bioactive [(E)-pyridin-3-ylmethylideneamino] N-(4-octoxyphenyl)carbamate
CFAMM00283473 CHEMBL597728 Bioactive [(E)-pyridin-3-ylmethylideneamino] N-(4-pentoxyphenyl)carbamate
CFAMM00283465 CHEMBL598557 Bioactive [(E)-pyridin-3-ylmethylideneamino] N-(4-nonoxyphenyl)carbamate
CFAMM00283471 CHEMBL597729 Bioactive [(E)-pyridin-3-ylmethylideneamino] N-(4-hexoxyphenyl)carbamate
CFAMM00283462 CHEMBL605005 Bioactive [(E)-pyridin-3-ylmethylideneamino] N-(4-heptoxyphenyl)carbamate
CFAMM00283477 CHEMBL598764 Bioactive [(E)-pyridin-3-ylmethylideneamino] N-(4-undecoxyphenyl)carbamate
CFAMM00283476 CHEMBL598558 Bioactive [(E)-pyridin-3-ylmethylideneamino] N-(4-decoxyphenyl)carbamate
CFAMM00283472 DNC010406 Investigative Drug pyridin-3-yl 4-butoxybenzylcarbamate
CFAMM00283461 DNC010427 Investigative Drug nicotinaldehyde O-4-ethoxyphenylcarbamoyl oxime

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48712 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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