CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID308
Family Name Nicotinic acetylcholine receptor Ligand Epibatidine Family
No. of Seeds 36 No. of Other Members 19
Family Centroid CFAMM00186923 Functional Category Investigative Drug
Superfamily Histamine H1 receptor ligand tricyclic antidepressant Superfamily
Class Class 88

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Acetylcholinesterase Inhibitor Tacrine Family 12 515
D(2) dopamine receptor Ligand Sertindole Family 3 173
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
G protein-activated inward rectifier potassium channel 4 Ligan... 3 48
Transient receptor potential cation channel subfamily V member... 16 295
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 23 63
Amg 423 family 7 47
ABC294640 family 5 75
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Carbonic anhydrase 2 Inhibitor Cyanamide Family 2 32
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 3 15
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 43 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-(4-phenylb... 6 32
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 10 18
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 6
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Histone deacetylase Inhibitor ST-5732 Family 8 6
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
5-hydroxytryptamine receptor 1A and D(1A) dopamine receptor li... 2 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 4 5
Sodium-dependent serotonin transporter inhibitor SureCN6087392... 1 1
Sodium-dependent serotonin transporter inhibitor SureCN6087152... 1 0
D(4) dopamine receptor and D(1A) dopamine receptor ligand 2-[[... 5 4
Prostaglandin G/H synthase 2 inhibitor SureCN6998947 family 1 1
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 0
Acetylcholine receptor subunit delta ligand Guanidine, N-[(6-c... 2 15
Acetylcholine receptor subunit delta and Neuronal acetylcholin... 3 5
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Sodium-dependent serotonin transporter inhibitor SureCN9171444... 2 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Glucocorticoid receptor and Androgen receptor ligand AGN-PC-0A... 3 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 5 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 10
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 5
Melanin-concentrating hormone receptor 2 and Sodium-dependent ... 2 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 2
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 8 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 0
5-hydroxytryptamine receptor 6 ligand 5-[3-(2-aminoethyl)indol... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 1
CGMP-dependent protein kinase inhibitor methyl 2-[[4-[5-(4-flu... 6 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 7
D(4) dopamine receptor and D(1A) dopamine receptor ligand AGN-... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 2 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 5
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 0
D(3) dopamine receptor and D(4) dopamine receptor ligand (7S)-... 1 2
CGMP-dependent protein kinase inhibitor AGN-PC-075INU family 1 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 10 1
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 2 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 0
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 5
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 17
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Thymidylate synthase inhibitor AGN-PC-00EUGY family 2 7
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 7
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 1 1
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2,3-dichlorop... 1 1
Farnesyl pyrophosphate synthase inhibitor [[(5-benzylpyridin-3... 1 0
Kinesin-like protein KIF11 inhibitor AGN-PC-077SFB family 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
methyl-1H-pyrrole NP (z)-2-((3,4-dimethyl-1h-pyrrol-2-yl)methy... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00186945 CHEMBL535619 Bioactive AGN-PC-07C16K
CFAMM00186911 CHEMBL54686 Bioactive CHEBI:186501
CFAMM00186937 CHEMBL6623 Bioactive (+/-)-Epibatidine
CFAMM00186952 CHEMBL357016 Bioactive (3R)-3-(5,6-dichloropyridin-3-yl)-7-azabicyclo[2.2.1]heptane
CFAMM00186917 CHEMBL56806 Bioactive SureCN8045774
CFAMM00186910 CHEMBL54902 Bioactive (1S)-3-(6-chloropyridin-3-yl)-7-azabicyclo[2.2.1]heptane
CFAMM00186929 CHEMBL513692 Bioactive (1R,3R,4R)-3-(6-chloropyridin-3-yl)-7-azabicyclo[2.2.1]heptane
CFAMM00186943 CHEMBL197526 Bioactive AGN-PC-075XGG
CFAMM00186935 CHEMBL537677 Bioactive AGN-PC-07C1DO
CFAMM00186915 CHEMBL366126 Bioactive AGN-PC-073R9I
CFAMM00186928 CHEMBL55003 Bioactive (1R,3S,4S)-3-(6-chloropyridin-3-yl)-7-methyl-7-azabicyclo[2.2.1]heptane
CFAMM00186921 CHEMBL186070 Bioactive (5R)-5-(6-chloropyridin-3-yl)-2-azabicyclo[2.2.1]heptane
CFAMM00186934 CHEMBL417027 Bioactive AGN-PC-073TSG
CFAMM00186948 CHEMBL298826 Bioactive Epibatidine
CFAMM00186914 CHEMBL1084416 Bioactive 3-[5-[(1S,3R,4R)-7-azabicyclo[2.2.1]heptan-3-yl]-2-chloropyridin-3-yl]-N,N-dimethylaniline
CFAMM00186927 CHEMBL94427 Bioactive homoepibatidine
CFAMM00186955 CHEMBL220476 Bioactive syn-isoepibatidine
CFAMM00186947 CHEMBL186302 Bioactive (5S)-5-(6-chloropyridin-3-yl)-3-azabicyclo[2.2.1]heptane
CFAMM00186913 CHEMBL406222 Bioactive 3-(4-chlorophenyl)deschloroepibatidine
CFAMM00186926 CHEMBL291961 Bioactive 3-(6-chloro-5-phenylpyridin-3-yl)-7-azabicyclo[2.2.1]heptane
CFAMM00186940 CHEMBL300467 Bioactive AGN-PC-00EXJ5
CFAMM00186946 CHEMBL185667 Bioactive AGN-PC-00GJGX
CFAMM00186912 CHEMBL1939774 Bioactive AGN-PC-0BTHVP
CFAMM00186939 CHEMBL300996 Bioactive (1S,3R,4R)-3-(6-chloropyridin-3-yl)-7-methyl-7-azabicyclo[2.2.1]heptane
CFAMM00186923 DNC000612 Investigative Drug Epibatidine
CFAMM00186936 DNC007888 Investigative Drug 6'-methylepibatidine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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