CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3082
Family Name 5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropylchroman-3-amine Family
No. of Seeds 9 No. of Other Members 14
Family Centroid CFAMM00283602 Functional Category Investigative Drug with Natural Product
Superfamily Alpha adrenergic receptor Ligand Phenoxybenzamine Superfamily
Class Class 280

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
Beta-2 adrenergic receptor Ligand Bambuterol Family 4 9
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Histamine H1 receptor Ligand Diphenhydramine Family 5 75
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 4 35
Substance-P receptor Ligand Ezlopitant Family 10 207
D(3) dopamine receptor Ligand U-99194A Family 7 33
Acolbifene family 10 115
Dapoxetine family 3 40
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
DNA-dependent protein kinase catalytic subunit Inhibitor 4-mor... 7 54
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Histamine H3 receptor Ligand 1-(3-(2-(3-methoxyphenoxy)ethoxy)... 3 9
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
Cytochrome P450 2D6 Inhibitor 4-methylaminomethyl-7-methoxycou... 3 80
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Tyrosinase Inhibitor 1-(3-phenoxypropyl)-4-(piperidin-1-yl)pip... 2 13
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 10 6
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
Sigma non-opioid intracellular receptor 1 and 3-beta-hydroxyst... 15 11
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand N,N-... 3 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 7 0
D(3) dopamine receptor ligand S 14297 family 1 2
Substance-P receptor ligand AGN-PC-02K8FR family 1 3
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 7 4
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 5 334
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 117
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Estrogen receptor and Estrogen receptor beta ligand (2R,3R,4S)... 3 0
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Transporter and 5-hydroxytryptamine receptor 2C ligand CHEMBL1... 5 5
Histamine H3 receptor ligand SureCN6071181 family 2 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
5-hydroxytryptamine receptor 7 and Alpha-2C adrenergic recepto... 3 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 7
Substance-P receptor ligand SureCN8415737 family 3 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
Cathepsin B and Cathepsin S inhibitor (4S,5R)-4-(2,3-dimethylp... 1 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 1 0
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
Estrogen receptor and Estrogen receptor beta ligand SureCN8476... 2 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 2
Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... 3 9
C-C chemokine receptor type 4 ligand AGN-PC-07AKPI family 1 5
Histamine H3 receptor ligand (NE)-N-[2-[2-(dimethylamino)ethox... 3 2
DNA-(apurinic or apyrimidinic site) lyase and Inositol monopho... 1 22
Putative NP ZINC38197498 Family 28 0
NP 1-(7-hydroxyspiro[chroman-2,4'-piperidin]-1'-yl)ethanone Fa... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00283597 CHEMBL99713 Bioactive SureCN8823612
CFAMM00283605 CHEMBL41491 Bioactive AGN-PC-004FC4
CFAMM00283592 CHEMBL2112053 Bioactive (3S)-8-(2,6-dimethoxyphenyl)-N,N-dimethyl-3,4-dihydro-2H-chromen-3-amine
CFAMM00283601 CHEMBL183329 Bioactive (3R)-8-(2,6-dimethoxyphenyl)-N,N-dimethyl-3,4-dihydro-2H-chromen-3-amine
CFAMM00283588 DNC012100 Investigative Drug (5-Methoxy-chroman-3-yl)-dipropyl-amine
CFAMM00283602 DNC010463 Investigative Drug (R)-8-phenyl-N,N-dipropylchroman-3-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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