CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFID3098
Family Name Galanin receptor type 1 and Galanin receptor type 2 Ligand Galantide Family
No. of Seeds 55 No. of Other Members 132
Family Centroid CFAMM00283937 Functional Category Investigative Drug with Natural Product
Superfamily Galanin receptor type 2 and Galanin receptor type 1 Binder Superfamily
Class Class 1389

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand phenylpiperazine derivative Arip... 3 53
SUR1-type K(ATP) channel and SUR2-type K(ATP) channel Ligand R... 1 16
Beta-2 adrenergic receptor Ligand Formoterol Family 16 63
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Potassium voltage-gated channel subfamily H member 2 Ligand Do... 5 30
Sodium channel protein type 5 subunit alpha Ligand Proparacain... 2 26
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Sodium channel protein type 10 subunit alpha and Sodium channe... 1 7
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
Integrin alpha-4 Inhibitor R1295 Family 18 59
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
D(2) dopamine receptor Ligand Aplindore Fumarate Family 2 30
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 3 27
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 3 67
Substance-P receptor Ligand Ezlopitant Family 10 207
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Mucosal addressin cell adhesion molecule 1 Inhibitor PF-005476... 64 96
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
Dp-b99 family 1 5
Beta-2 adrenergic receptor Ligand Olodaterol Family 16 27
PH-797804 family 6 28
Cinitapride family 4 22
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Neuropeptide Y receptor type 1 Ligand BMS-193885 Family 3 11
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
Beta-3 adrenergic receptor Ligand Cgp 12177 Family 3 8
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
5-hydroxytryptamine receptor 1A Ligand Du 125530 Family 2 0
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
5-hydroxytryptamine receptor 6 Ligand Sb 258585 Family 11 121
Tubulin Inhibitor WR85915 Family 3 15
Sodium channel protein type 10 subunit alpha Ligand A-803467 F... 2 81
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 7 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 20 33
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 20
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 7 23
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Liga... 40 90
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Potassium ... 1 15
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 4-(2... 4 31
Oxytocin receptor and Vasopressin V1a receptor Ligand L-371257... 8 92
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Histamine H3 receptor Ligand A-349821 Family 49 228
Extracellular calcium-sensing receptor Ligand 2-furan-2-yl-3-p... 4 119
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Alpha-1A adrenergic receptor Ligand Ro-11-04253 Family 1 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 31
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Oxysterols receptor LXR-alpha Ligand N-{4-[2-(4-methoxyphenyl)... 3 16
Amyloid beta A4 protein Inhibitor SB-13 Family 1 2
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 11 13
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
Sodium channel protein type 10 subunit alpha and Sodium channe... 2 13
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 12 44
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Cholesteryl ester transfer protein Inhibitor Tetrahydroquinoli... 3 8
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Fatty-acid amide hydrolase 1 Inhibitor 2-fluorophenyl 4-(octyl... 15 9
Fatty-acid amide hydrolase 1 Inhibitor Benzaldehyde O-4-ethoxy... 21 4
Fatty-acid amide hydrolase 1 Inhibitor Phenmedipham Family 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 9
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 28 24
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 7
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 8 39
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Acetylcholinesterase Inhibitor 6-methyl-4-(4-phenylpiperazin-1... 6 622
Fatty-acid amide hydrolase 1 Inhibitor 4-nitrophenyl 4-benzylp... 5 35
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Neuropeptide Y receptor type 1 Ligand N-arylpiperazine Derivat... 5 4
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00G... 16 4
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
D(4) dopamine receptor ligand AGN-PC-004XJQ family 2 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 17
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 6
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 10
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Cannabinoid receptor 2 ligand 8-butoxy-N-(2-fluoro-2-phenyleth... 12 7
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 3 5
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 2
Pyruvate kinase PKLR and Pyruvate kinase PKM inhibitor AGN-PC-... 1 1
Transient receptor potential cation channel subfamily V member... 1 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
Beta-1 adrenergic receptor ligand 1-[2-[[(2S)-3-(2-cyanophenox... 10 4
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 4 6
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 9 22
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 15 14
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(4-... 3 5
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 2
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 6
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 2
Mu-type opioid receptor ligand N-[(3S,4R)-1-[(2S)-2-hydroxy-2-... 11 4
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 0
Alpha-2A adrenergic receptor and 5-hydroxytryptamine receptor ... 7 10
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 8
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 4 2
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 0
D(4) dopamine receptor and D(2) dopamine receptor ligand 7-[[4... 1 23
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 2
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 11 4
Alpha-1A adrenergic receptor and 5-hydroxytryptamine receptor ... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-3... 2 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Kappa-type opioid receptor ligand AGN-PC-09M90I family 2 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
D(3) dopamine receptor and D(1A) dopamine receptor ligand N-[(... 6 14
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 1 0
Renin inhibitor 6-[[(2R)-1-[4-[3-[(2-methoxyphenyl)methoxy]pro... 3 1
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 8 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Estrogen receptor and Estrogen receptor beta ligand SureCN5681... 7 3
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 9 37
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 4 8
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-01ZLS4 family 2 8
Transient receptor potential cation channel subfamily V member... 3 15
Androgen receptor ligand (6R,7R)-6,7-diethyl-4-(trifluoromethy... 15 20
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Neuropeptide S receptor and Prelamin-A/C ligand CHEMBL1352632 ... 1 25
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
Survival motor neuron protein and DNA-(apurinic or apyrimidini... 1 5
Acetylcholinesterase inhibitor trimethyl-(2-methyl-3-propanoyl... 3 2
Acetylcholinesterase inhibitor AGN-PC-075N8G family 2 9
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 3 1
Neutrophil collagenase and Stromelysin-1 inhibitor 7-[[(2S)-2-... 10 9
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-075O... 14 27
Nischarin inhibitor SureCN7818902 family 2 12
Neutrophil collagenase inhibitor (3R)-2-[4-[4-(dimethylamino)p... 2 4
Neutrophil collagenase and Stromelysin-1 inhibitor tert-butyl ... 2 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 2
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 4 4
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 7 4
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 0
Sodium-dependent serotonin transporter inhibitor SureCN3890472... 2 0
5-hydroxytryptamine receptor 6 ligand 1-(4-methoxy-3-piperazin... 6 3
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
5-hydroxytryptamine receptor 6 ligand 6-bromo-1-(4-methoxy-3-p... 2 0
Substance-P receptor ligand (2S,4S)-1-N-(3-chlorophenyl)-2-N-[... 5 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
Neuropeptide S receptor and Survival motor neuron protein liga... 1 2
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
5-hydroxytryptamine receptor 6 ligand AGN-PC-0BRZ7B family 9 2
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-088O2I family 3 3
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-088O2K family 2 0
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Melanin-concentrating hormone receptor 1 ligand 1-[1-(1-methyl... 5 10
Carbonic anhydrase 12 and Probable transmembrane carbonic anhy... 2 0
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 1 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
DNA-dependent protein kinase catalytic subunit and Phosphatidy... 1 6
Trace amine-associated receptor 1 ligand EPPTB family 4 9
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor N-[(1S,5aR,9... 2 2
Vasopressin V1b receptor ligand AGN-PC-09QGT9 family 4 123
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 11 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 3 0
Gonadotropin-releasing hormone receptor ligand SureCN5756131 f... 5 7
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 5 2
Mitogen-activated protein kinase 14 inhibitor 3-bromo-1-(2,6-d... 5 11
Integrin beta-1 and Integrin alpha-4 inhibitor AGN-PC-02YIN5 f... 3 5
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 1
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Sodium/bile acid cotransporter and Glucocorticoid receptor lig... 4 8
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 5
Cannabinoid receptor 2 ligand 8-butoxy-N-[2-(4-fluorophenyl)et... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-[2-... 3 0
Cannabinoid receptor 2 ligand 8-butoxy-7-methoxy-2-oxo-1H-quin... 1 0
Neuropeptide Y receptor type 5 ligand 2-(7-chloro-3-oxo-1,4-be... 3 3
Neuropeptide Y receptor type 5 ligand N-[[4-[2-[7-(trifluorome... 1 1
Histamine H3 receptor ligand SureCN1373218 family 2 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 5
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 16 6
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 0
Transient receptor potential cation channel subfamily V member... 1 0
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Histamine H3 receptor ligand 1-methyl-5-[4-[3-[(2R)-2-methylpy... 5 5
Histamine H3 receptor ligand 5-[4-[3-[(2R)-2-methylpyrrolidin-... 2 3
Renin and Cytochrome P450 3A4 inhibitor SureCN6719989 family 2 0
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 2 3
MAP kinase-activated protein kinase 2 inhibitor 5-(4-cyanophen... 3 8
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 1
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Cathepsin S and Cathepsin K inhibitor arylaminoethyl amide, 7 ... 2 0
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 3
C-C chemokine receptor type 1 ligand SureCN3164653 family 2 1
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 4 19
Sodium-dependent serotonin transporter inhibitor 2-[2-[(dimeth... 3 3
Renin inhibitor 5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4... 5 9
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(4... 10 0
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(2... 2 0
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-(2,... 2 11
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 0
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 3 3
Translocator protein inhibitor AGN-PC-00CH84 family 3 0
D(2) dopamine receptor and Muscarinic acetylcholine receptor M... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Translocator protein inhibitor [11C]DAA1106 family 15 2
Translocator protein inhibitor N-[(2,5-dimethoxyphenyl)methyl]... 1 0
Microsomal triglyceride transfer protein large subunit inhibit... 3 0
Translocator protein inhibitor N-methyl-2-[2-oxo-5-[4-(trifluo... 9 3
Translocator protein inhibitor N-methyl-2-[5-(N-methylanilino)... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Motilin receptor ligand SureCN14564469 family 1 6
Galanin receptor type 3 and Alpha-1A adrenergic receptor ligan... 2 16
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 3
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
C-C chemokine receptor type 3 ligand 1-[(3R)-1-[(6-fluoronapht... 2 6
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 6 3
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 3
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 0
Cathepsin K inhibitor (1R,2R)-N-(cyanomethyl)-2-[4-(3-methoxyp... 2 1
C-C chemokine receptor type 1 ligand N-[2-[(2S)-3-(5-chlorospi... 5 0
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 2 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN3178516 family 3 1
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
C-X-C chemokine receptor type 3 ligand N-(2-ethoxyethyl)-N-[(1... 1 1
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 10 1
Translocator protein inhibitor CHEMBL2332256 family 1 0
C-C chemokine receptor type 1 ligand N-[2-[(2S)-3-(5-chlorospi... 4 0
C-C chemokine receptor type 1 ligand N-[2-[(2S)-2-amino-3-(5-f... 3 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 5 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 1
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 3 0
Growth hormone secretagogue receptor type 1 ligand SureCN47962... 8 0
Growth hormone secretagogue receptor type 1 ligand SureCN48020... 3 0
Nociceptin receptor and Mu-type opioid receptor ligand SureCN7... 13 22
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 8
Histamine H3 receptor and Histamine receptor H3 ligand 1-[4-[3... 2 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-(3,5-... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 4-met... 3 3
5-hydroxytryptamine receptor 7 ligand 1-(2-methoxyphenyl)-4-[2... 6 2
Nociceptin receptor and Mu-type opioid receptor ligand N-ethyl... 8 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 8
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 10
Poly [ADP-ribose] polymerase 1 inhibitor 3-chloro-N-cyclopropy... 1 2
Poly [ADP-ribose] polymerase 1 inhibitor N-ethyl-4-[4-[(8-meth... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor 6-[[4-(4-chlorophenyl... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2
Ghrelin/growth hormone secretagogue receptor and Cytochrome P4... 5 20
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 3
D(3) dopamine receptor and D(2) dopamine receptor ligand (5R)-... 2 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-ethylbutanoyl)... 11 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 2
Coagulation factor X and Cationic trypsin inhibitor 3-[(E)-3-[... 3 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 5
Glutamate receptor ionotropic, NMDA 2B and Potassium voltage-g... 2 1
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 7 1
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 10 2
Oxytocin receptor ligand SureCN8092936 family 2 0
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 20 23
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 4 2
Progesterone receptor ligand CHEMBL252850 family 2 0
Progesterone receptor ligand CHEMBL253735 family 2 0
Mitogen-activated protein kinase 14 inhibitor (2R)-2-amino-N-[... 9 0
Urotensin-2 receptor and Kappa-type opioid receptor ligand 6,7... 2 0
Alpha-1D adrenergic receptor and D(2) dopamine receptor ligand... 3 0
Urotensin-2 receptor and Cytochrome P450 3A4 ligand 5-chloro-3... 2 1
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 2
5-hydroxytryptamine receptor 1A ligand SureCN10513645 family 9 1
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Delta-type opioid receptor and Kappa-type opioid receptor liga... 5 0
5-hydroxytryptamine receptor 1A ligand AGN-PC-0034EG family 5 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 7
5-hydroxytryptamine receptor 1A ligand 3-hydroxy-6-iodo-2-[2-[... 2 0
C-C chemokine receptor type 5 ligand dimethyl-[[4-[[7-(4-methy... 7 8
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Hormone-sensitive lipase inhibitor SureCN7553414 family 1 1
5-hydroxytryptamine receptor 1A ligand (1R,2R)-2-[4-(2,3-dihyd... 2 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 10
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 4 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Neuropeptide Y receptor type 5 ligand 3-[4-(4-fluorophenoxy)ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZ6 family 3 6
Mu-type opioid receptor ligand AGN-PC-00NCMO family 3 1
Substance-P receptor ligand CP 141938 family 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 2
Urotensin-2 receptor ligand SureCN4431593 family 1 7
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 13
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 1-acety... 6 7
Sigma non-opioid intracellular receptor 1 ligand (5S)-5-[(4-hy... 1 5
Glucagon receptor and Adenylate cyclase type 1 ligand AGN-PC-0... 3 1
D(3) dopamine receptor ligand rac S 33138 family 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 0
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 1-benzo... 6 7
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 1 0
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(3-hydr... 1 0
Transient receptor potential cation channel subfamily V member... 1 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 16 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-00RZQT family 3 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1
Histamine H3 receptor ligand AGN-PC-00AE5Q family 13 13
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJY family 5 4
Prothrombin and Coagulation factor X inhibitor AGN-PC-04SR80 f... 5 24
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KFD family 1 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 9
Histamine H3 receptor and Potassium voltage-gated channel subf... 28 30
Histamine H3 receptor ligand AGN-PC-03Z8HJ family 4 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
Growth hormone secretagogue receptor type 1 ligand N-[4-[(2S)-... 1 0
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 2 2
Histamine H3 receptor ligand AGN-PC-077MDJ family 2 1
Orexin receptor type 2 and Orexin receptor type 1 ligand AGN-P... 2 0
Hormone-sensitive lipase inhibitor [4-[(4-tert-butylcyclohexan... 2 1
Lanosterol synthase inhibitor AGN-PC-07BZTC family 1 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 12
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
Histamine H3 receptor ligand SureCN3057839 family 1 0
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 9 0
Acyl-CoA desaturase and Acyl-CoA desaturase 1 inhibitor SureCN... 1 0
Cathepsin E and Cathepsin D inhibitor SureCN2529506 family 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 1 7
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor SureCN8058778 family 13 4
Sterol O-acyltransferase 1 inhibitor SureCN6152927 family 7 3
Histamine H3 receptor ligand AGN-PC-07ZCFA family 1 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor AGN-PC-007ZS... 3 3
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 9
Mitogen-activated protein kinase 14 inhibitor AGN-PC-00A4QT fa... 2 0
Peptide deformylase inhibitor (2S)-N-(cyclopropylmethyl)-N-[2-... 1 0
C-C chemokine receptor type 3 ligand SureCN6700764 family 2 2
5-hydroxytryptamine receptor 7 ligand 4-[4-(2-ethoxyphenyl)pip... 2 5
Prelamin-A/C and Nonstructural protein 1 inhibitor CHEMBL14536... 1 2
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 1 1
Leukotriene B4 receptor 1 ligand 4-methoxy-3-[[(E)-3-(4-phenyl... 2 10
Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)... 4 16
Transient receptor potential cation channel subfamily V member... 2 7
DNA polymerase III PolC-type inhibitor 6-(3-ethyl-4-methylanil... 1 0
Calcitonin gene-related peptide type 1 receptor ligand 2-(4-me... 4 4
P2X purinoceptor 7 inhibitor SureCN3722920 family 4 0
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 2 0
C-X-C chemokine receptor type 3 ligand 1-[1-[[(1S,5R)-6,6-dime... 2 3
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 6
Coagulation factor X inhibitor N-[1-[2-fluoro-4-(2-methylsulfo... 2 2
Gonadotropin-releasing hormone receptor ligand CHEMBL260816 fa... 1 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Arachidonate 5-lipoxygenase inhibitor ethyl (E)-3-(10H-phenoxa... 1 1
Cathepsin K inhibitor N-[2-(4-methoxyanilino)ethyl]-4-methyl-2... 1 1
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN9818603 f... 2 2
Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... 3 9
Cyclin-dependent kinase 4 inhibitor SureCN3563106 family 1 1
Elongation of very long chain fatty acids protein 6 inhibitor ... 2 7
Sterol O-acyltransferase 1 inhibitor SureCN5812305 family 1 0
Menin and Histone-lysine N-methyltransferase 2A inhibitor CHEM... 1 0
Huntingtin and Retinal dehydrogenase 1 inhibitor CHEMBL1467512... 1 0
Beta-lactamase and 4'-phosphopantetheinyl transferase ffp inhi... 1 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075HBO ... 2 44
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-[2-... 1 1
Multidrug resistance protein 1 inhibitor (1R)-2-[4-(2-methoxyp... 2 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor AGN-PC-04F7M... 1 3
Acyl-CoA:cholesterol acyltransferase inhibitor [2,6-di(propan-... 1 0
4,4,6-trimethyl-1,3-dihydroimidazo[1,2-a]indol-2-one NP ZINC02... 37 0
NP (s)-3-(2,5-dioxo-2,3,4,5-tetrahydro-1h-benzo[e][1,4]diazepi... 3 0
4-(4-methoxyphenyl)-2,4,5,10-tetrahydro-1H-pyrrolo[3,4-c][1,5]... 4 0
8,10,10-trimethyl-3,4-dihydro-1H-pyrimido[1,2-a]indol-2-one NP... 14 0
3-[(3-amino-4-methoxybenzoyl)amino]propanoate NP Agn-pc-09e1h5... 1 1
3,5-bis[[2-(4-methoxyphenoxy)acetyl]amino]benzoate NP Agn-pc-0... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00283851 CHEMBL184486 Bioactive STK289176
CFAMM00283825 CHEMBL351642 Bioactive N-(2-methoxyphenyl)-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
CFAMM00283952 CHEMBL1642484 Bioactive SureCN2890948
CFAMM00283873 CHEMBL2070789 Bioactive N-(2-cyclopentyloxyphenyl)-2-fluoro-N-[(2-methoxyphenyl)methyl]acetamide
CFAMM00283822 CHEMBL167362 Bioactive N-(2-ethoxyphenyl)-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
CFAMM00283951 CHEMBL1642485 Bioactive AGN-PC-00CBXJ
CFAMM00283788 CHEMBL150129 Bioactive SureCN6909154
CFAMM00283950 CHEMBL1642482 Bioactive SureCN1753676
CFAMM00283904 CHEMBL257171 Bioactive 6,7-dimethyl-4-[2-oxo-2-[3-phenyl-2-(pyrrolidin-1-ylmethyl)piperidin-1-yl]ethyl]-1,4-benzoxazin-3-one
CFAMM00283777 CHEMBL220641 Bioactive AGN-PC-00CO11
CFAMM00283937 DNC010530 Investigative Drug GALANTIDE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

22656 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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