CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3100
Family Name Amine oxidase [flavin-containing] A and Amine oxidase [flavin-containing] B Inhibitor (+/-)-2-(4'-butoxyphenyl)thiomorpholin-5-one Family
No. of Seeds 10 No. of Other Members 15
Family Centroid CFAMM00283999 Functional Category Investigative Drug with Natural Product
Superfamily Amine oxidase [flavin-containing] A and Amine oxidase [flavin-containing] B Inhibitor (+/-)-2-(4'-butoxyphenyl)thiomorpholin-5-one Superfamily
Class Class 412

Cousin Family NamesSeedsMembers
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Dulo... 8 6
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Zucapsacin family 7 177
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Substance-P receptor Ligand Ezlopitant Family 10 207
Dapoxetine family 3 40
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(3,5-dimethoxyphenethyl)oleami... 5 49
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Potassium voltage-gated channel subfamily A member 5 Ligand 3-... 2 14
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
Indoleamine 2,3-dioxygenase 1 Inhibitor S-(4-methoxybenzyl)iso... 1 2
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
5-hydroxytryptamine receptor 1A Ligand Tertatolol Family 1 1
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Voltage-dependent calcium channel gamma-1 subunit Ligand 4-(3-... 3 18
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Cathepsin K inhibitor [1-(3-methoxyphenyl)-2-methylpropan-2-yl... 2 10
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor S-[3-(4-m... 1 2
Leukotriene A-4 hydrolase inhibitor 3-[3-(4-benzylphenoxy)prop... 2 0
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Histamine H3 receptor ligand SureCN5093910 family 3 16
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 14 1
Macrophage metalloelastase and Collagenase 3 inhibitor (2S)-N-... 2 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 1-benzy... 13 3
Melatonin receptor type 1A ligand 4-(2,3-dihydro-1,4-benzoxath... 1 0
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
Survival motor neuron protein and Thioredoxin glutathione redu... 1 0
Trace amine-associated receptor 1 ligand SureCN13886619 family 1 1
Trace amine-associated receptor 1 ligand 4-[4-(2-AMINO-ETHYL)-... 1 0
Dipeptidyl peptidase 4 inhibitor SureCN3165078 family 2 6
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 3
Beta-secretase 1 and Cathepsin D inhibitor 3-(dibutylsulfamoyl... 2 0
NP N-(2-methoxyphenethyl)-5-((3as,4s,6ar)-2-oxohexahydro-1h-th... 2 0
Putative NP ZINC04061066 Family 18 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00284015 DNC010541 Investigative Drug (+/-)-2-(4'-Benzyloxyphenyl)thiomorpholine
CFAMM00284006 DNC014220 Investigative Drug (+/-)-2-(4'-Methoxyphenyl)thiomorpholin-5-one
CFAMM00284013 DNC010547 Investigative Drug (+/-)-2-(4'-Propoxyphenyl)thiomorpholin-5-one
CFAMM00284019 DNC010549 Investigative Drug (+/-)-2-(4'-Methoxyphenyl)thiomorpholine
CFAMM00284012 DNC010546 Investigative Drug (+/-)-2-(4'-Ethoxyphenyl)thiomorpholine
CFAMM00283999 DNC010545 Investigative Drug (+/-)-2-(4'-Butoxyphenyl)thiomorpholin-5-one
CFAMM00284018 DNC010548 Investigative Drug (+/-)-2-(4'-Ethoxyphenyl)thiomorpholin-5-one
CFAMM00284017 DNC010543 Investigative Drug (+/-)-2-(4'-Butoxyphenyl)thiomorpholine
CFAMM00284010 DNC010544 Investigative Drug (+/-)-2-(4'-Benzyloxyphenyl)thiomorpholin-5-one
CFAMM00284016 DNC010542 Investigative Drug (+/-)-2-(4'-Propoxyphenyl)thiomorpholine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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