CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3122
Family Name Cytochrome P450 2D6 Inhibitor 4-methylaminomethyl-7-methoxycoumarin Family
No. of Seeds 3 No. of Other Members 80
Family Centroid CFAMM00284538 Functional Category Investigative Drug with Natural Product
Superfamily Cytochrome P450 2D6 Inhibitor 4-methylaminomethyl-7-methoxycoumarin Superfamily
Class Class 2426

Cousin Family NamesSeedsMembers
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Ipriflavone family 62 2480
Salicin family 5 629
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Acolbifene family 10 115
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Platelet-activating factor receptor Ligand L-652731 Family 5 116
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
DNA-dependent protein kinase catalytic subunit Inhibitor 4-mor... 7 54
Cannabinoid receptor 1 Ligand N-(3,5-dimethoxyphenethyl)oleami... 5 49
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 127
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 160
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-amino-2h-chromen... 2 3
Kappa-type opioid receptor Ligand Anisocoumarin H Family 3 5
Androgen receptor Ligand 2-methoxy-4-(o-tolyloxy)benzonitrile ... 5 12
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
NAD(P)H dehydrogenase [quinone] 1 Inhibitor Ethyl Bis(4-hydrox... 5 7
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Acetylcholinesterase Inhibitor 6-methyl-4-(4-phenylpiperazin-1... 6 622
Androgen receptor Ligand Palodesangren E Family 12 43
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
Neuropeptide S receptor and Prelamin-A/C ligand CHEMBL1352632 ... 1 25
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 5 334
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 191
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 0
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 0
Histamine H1 receptor ligand 7-[3-[4-[(4-chlorophenyl)methyl]p... 3 5
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-[(4... 3 53
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 3 2
Acetylcholinesterase and Butyrylcholinesterase inhibitor [3-[[... 1 65
C-C chemokine receptor type 4 ligand AGN-PC-07AKPI family 1 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 7
Amine oxidase [flavin-containing] B inhibitor (2S)-1-[[7-[(3-f... 2 15
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 1
NP Agn-pc-096s84 Family 40 0
propanoate NP 8-methyl-2-oxo-4-phenyl-2h-chromen-7-yl 3-((tert... 30 0
NP 2-(7-methoxy-4,8-dimethyl-2-oxo-2h-chromen-3-yl)-n-(3-(2-ox... 3 0
[(2S)-3-(4,8-dimethyl-2-oxochromen-7-yl)oxy-2-hydroxypropyl]-(... 1 1
NP Agn-pc-05g5on Family 11 0
9,10-dihydro-8H-pyrano[2,3-f][1,3]benzoxazin-9-ium-2-one NP Ag... 6 0
7-hydroxy-8-[[4-(2-hydroxyethyl)piperazin-1-ium-1-yl]methyl]ch... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00284549 CHEMBL593763 Bioactive AGN-PC-046YCF
CFAMM00284538 DNC010615 Investigative Drug 4-methylaminomethyl-7-methoxycoumarin
CFAMM00284553 DNC014138 Investigative Drug 4-(Aminomethyl)-7-(benzyloxy)-2H-chromen-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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