CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3124
Family Name Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(furan-2-yl)-3,4'-bipyridin-6-yl)acetamide Family
No. of Seeds 21 No. of Other Members 108
Family Centroid CFAMM00284613 Functional Category Investigative Drug with Natural Product
Superfamily Adenosine receptor A1 and Adenosine receptor A2a Binder Superfamily 9
Class Class 2579

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Kinetin family 2 39
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Neuronal acetylcholine receptor subunit alpha-4 Ligand TC-5619... 3 61
Adenosine receptor A2a Ligand BIIB014 Family 26 92
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
MK-3328 family 2 32
Smoothened homolog Inhibitor LDE225 Family 3 76
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
MK-6096 family 3 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand CGS-15... 24 47
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 37
Serine/threonine-protein kinase Chk1 Inhibitor N-(5,6-diphenyl... 9 100
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Fatty-acid amide hydrolase 1 Inhibitor 1-(oxazolo[4,5-b]pyridi... 19 34
Adenosine receptor A1 and Adenosine receptor A2a Ligand ZM-241... 2 5
Vascular endothelial growth factor receptor 1 and Vascular end... 4 44
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Mitogen-activated protein kinase 14 Inhibitor CP-808844 Family 39 43
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
5-hydroxytryptamine receptor 3A and Neuronal acetylcholine rec... 1 3
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-amin... 3 15
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Coagulation factor X and Prothrombin Inhibitor BMS-344577 Family 13 12
5-hydroxytryptamine receptor 2C Ligand 4-(piperazin-1-yl)furo[... 3 11
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Sodium-dependent serotonin transporter Inhibitor 4-furan-2-yl-... 2 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Divapl... 3 47
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
Reverse transcriptase/RNaseH inhibitor AC1LALKM family 2 19
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 6
Peroxisome proliferator-activated receptor delta ligand SureCN... 8 19
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 1 0
Potassium voltage-gated channel subfamily H member 2 and Neuro... 3 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 9 3
Histamine H4 receptor and Histamine H3 receptor ligand SureCN6... 17 51
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 1
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
Adenosine receptor A2a ligand SureCN6867940 family 13 13
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Receptor-type tyrosine-protein kinase FLT3 and Hepatocyte grow... 7 56
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Gonadotropin-releasing hormone receptor ligand AGN-PC-034WF4 f... 8 23
Dipeptidyl peptidase 8 and Dipeptidyl peptidase 9 inhibitor Su... 3 1
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 6 9
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 3
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
Ferritin light chain and Ras-related protein Rab-9A inhibitor ... 1 11
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 8 0
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Adenosine receptor A3 and Adenosine receptor A2b ligand CHEMBL... 5 0
Survival motor neuron protein and Neuropeptide S receptor liga... 1 2
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 7 4
Cathepsin S and Cathepsin K inhibitor N-[(2S)-3-(1-methylcyclo... 2 0
Cytochrome P450 2C19 and Inositol monophosphatase 1 inhibitor ... 1 0
Inosine-5'-monophosphate dehydrogenase inhibitor SureCN1318237... 2 12
Mu-type opioid receptor ligand Mirfentanil family 1 0
Histamine H3 receptor ligand SureCN7251693 family 3 1
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 5 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Adenosine receptor A2b and Adenosine receptor A2a ligand AGN-P... 2 0
Adenosine kinase inhibitor 7-[(4aS,7aS)-6-benzyl-3,4,4a,5,7,7a... 2 1
Adenosine receptor A2a ligand 5-[[[(2R)-1-[(2-chloropyridin-4-... 5 0
Adenosine receptor A2a ligand 2-(furan-2-yl)-7-[3-[(4-phenylpi... 11 2
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
5-hydroxytryptamine receptor 1F ligand AGN-PC-075AYH family 2 1
Adenosine receptor A2a ligand 7-(3,4-dimethoxyphenyl)-2-(furan... 6 1
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 1 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 5
Fatty-acid amide hydrolase 1 inhibitor 2-(1,3-dihydroisoindol-... 2 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 2 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 6 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor CHEM... 1 0
Adenosine receptor A3 ligand CHEMBL1834703 family 2 1
Vascular endothelial growth factor receptor 1 and Vascular end... 11 38
Histamine H4 receptor ligand 8-fluoro-4-[(3R)-3-(methylamino)p... 6 1
Histamine H4 receptor ligand 8-chloro-4-[(3R)-3-(methylamino)p... 1 1
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Histamine H4 receptor and Histamine H3 receptor ligand 7-(fura... 2 2
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1938684 ... 5 6
Prothrombin inhibitor SureCN6925359 family 6 18
Melanin-concentrating hormone receptor 1 ligand N-[1-(1,3-benz... 2 5
Adenosine receptor A2a ligand 9-[(6-chloro-1,3-benzodioxol-5-y... 1 0
Histamine H3 receptor ligand 2-(4-piperidin-1-ylpiperidin-1-yl... 1 3
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 0
Adenosine receptor A2b ligand 2-[5-(2,6-dioxo-1,3-dipropyl-7H-... 1 0
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 1 0
MAP kinase-activated protein kinase 2 inhibitor 4-[5-[4-(4-pip... 1 11
Tubulin beta-4A chain and Tubulin beta-2B chain inhibitor N-(2... 1 4
Glycogen synthase kinase-3 beta inhibitor 2-(furan-3-yl)-N-[2-... 3 3
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 8
Activated CDC42 kinase 1 inhibitor 6-[4-(2-morpholin-4-ylethox... 7 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Tyrosine-protein kinase SYK inhibitor 4-[[3-[8-[(5,6-dimethoxy... 2 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 3 3
Scavenger receptor class B member 1 ligand 2-[9-[3-(4,6-dimeth... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 6
Vascular endothelial growth factor receptor 2 and Platelet-der... 16 11
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 2
Adenosine receptor A2a and Adenosine receptor A1 ligand 5-[(7S... 6 1
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Protein-cysteine N-palmitoyltransferase porcupine inhibitor N-... 4 4
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
G-protein coupled bile acid receptor 1 ligand 2-ethyl-6-[3-[4-... 4 6
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
MAP kinase-activated protein kinase 2 inhibitor 4-[4-oxo-8-pip... 4 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0DB8TJ family 2 0
G1/S-specific cyclin-E1 and Cyclin-dependent kinase 2 inhibito... 1 4
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Metabotropic glutamate receptor 5 and Cytochrome P450 3A4 liga... 3 7
Tyrosine-protein kinase ITK/TSK and Aurora kinase B inhibitor ... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 3
Adenosine receptor A2a ligand 3-[(2-bromophenyl)methyl]-8-(fur... 2 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Adenosine receptor A2a ligand 8-(furan-2-yl)-3-[2-[4-(1,3-thia... 2 2
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 5
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 25 5
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 29 1
Adenosine receptor A2a and Adenosine receptor A1 ligand 1-[(2-... 2 0
Cathepsin K and Cathepsin L1 inhibitor AC1NR9VX family 2 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 1
Mitogen-activated protein kinase 14 inhibitor 4-[4-(4-fluoroph... 1 5
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 1 2
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-075YVI ... 1 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor Isoquinoli... 1 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 3 0
Platelet-activating factor receptor ligand AGN-PC-00GDIY family 1 1
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6
Adenosine receptor A2b and Adenosine receptor A1 ligand [4-(2,... 6 15
Transient receptor potential cation channel subfamily V member... 2 0
C-C chemokine receptor type 3 ligand SureCN6338683 family 1 2
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-03J2ZU f... 1 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 2 2
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 2 0
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 19 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 2
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-077D0D family 3 0
Protein kinase C theta type and Protein kinase C delta type in... 5 4
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 1 3
Collagenase 3 inhibitor SureCN1316041 family 4 3
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Adenosine receptor A2a and Adenosine receptor A1 ligand triazi... 3 0
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 0
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M5I2 fa... 1 3
Serine/threonine-protein kinase Chk1 and Cyclin-A2 inhibitor S... 1 0
Diacylglycerol O-acyltransferase 1 inhibitor SureCN2789698 family 2 8
Fatty-acid amide hydrolase 1 inhibitor (Z)-1-(4-pyrimidin-4-yl... 1 0
Aurora kinase B and Aurora kinase A inhibitor N-(furan-2-ylmet... 2 1
Metabotropic glutamate receptor 5 ligand 3-fluoro-5-(5-pyridin... 1 0
Diacylglycerol O-acyltransferase 1 inhibitor 3-[[1-[5-[[2-(3-m... 1 1
Diacylglycerol O-acyltransferase 1 inhibitor 2-[[4-[5-[(3-meth... 2 6
G-protein coupled bile acid receptor 1 ligand N-[3,5-bis(trifl... 1 0
Diacylglycerol O-acyltransferase 1 inhibitor ethyl 4-[5-[[2-(3... 5 8
Nonstructural protein 1 and Beta-lactamase inhibitor CHEMBL138... 1 0
Arachidonate 15-lipoxygenase and Nonstructural protein 1 inhib... 1 0
Beta-lactamase and Nonstructural protein 1 inhibitor CHEMBL146... 1 0
Metabotropic glutamate receptor 5 ligand AGN-PC-09QKEE family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00284662 CHEMBL594676 Bioactive SureCN930795
CFAMM00284589 CHEMBL1672619 Bioactive AGN-PC-00SHBM
CFAMM00284682 CHEMBL1082005 Bioactive AGN-PC-07Z9TK
CFAMM00284620 CHEMBL571672 Bioactive SureCN928883
CFAMM00284718 CHEMBL608102 Bioactive AGN-PC-076XLF
CFAMM00284639 CHEMBL173949 Bioactive 2,4,6-trifluoro-N-[3-(1-methylpiperidin-4-yl)furo[3,2-b]pyridin-5-yl]benzamide
CFAMM00284588 CHEMBL1672612 Bioactive AGN-PC-00SHHQ
CFAMM00284627 CHEMBL345120 Bioactive N-[1-(2-phenylethyl)piperidin-4-yl]-N-pyridin-2-ylfuran-2-carboxamide
CFAMM00284587 CHEMBL1672611 Bioactive AGN-PC-00SHHS
CFAMM00284699 CHEMBL1079803 Bioactive AGN-PC-07Z9SD
CFAMM00284586 CHEMBL1672615 Bioactive AGN-PC-00SHHT
CFAMM00284698 CHEMBL1079804 Bioactive AGN-PC-07ZZ36
CFAMM00284712 CHEMBL347188 Bioactive N-(2-(4-Methylpyridinyl))-N-(1-phenethyl-4-piperidinyl)-2-furamide
CFAMM00284622 CHEMBL177258 Bioactive 4-fluoro-N-[3-(1-methylpiperidin-4-yl)furo[3,2-b]pyridin-5-yl]benzamide
CFAMM00284590 CHEMBL1081812 Bioactive AGN-PC-07ZZ34
CFAMM00284613 DNC010621 Investigative Drug N-(2-(furan-2-yl)-3,4'-bipyridin-6-yl)acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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