CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3135
Family Name Sodium-dependent dopamine transporter and Sodium-dependent noradrenaline transporter Inhibitor PF-18298 Family
No. of Seeds 19 No. of Other Members 28
Family Centroid CFAMM00285132 Functional Category Investigative Drug
Superfamily Substance-K receptor and Substance-P receptor Ligand DNK-333 Superfamily
Class Class 496

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Tumor necrosis factor Inhibitor Thalidomide Family 3 50
Acetylcholinesterase Inhibitor Ambenonium Family 4 71
DNA Binder Procarbazine Family 8 358
Neuromedin-K receptor Ligand Osanetant Family 38 192
Motilin receptor Ligand GSK962040 Family 30 457
Kappa-type opioid receptor Ligand Asimadoline Family 14 54
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
C-C chemokine receptor type 5 Ligand Tak-220 Family 8 56
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Poly [ADP-ribose] polymerase 1 Inhibitor 3,4-dihydro-5-methyl-... 3 2
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 10 52
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 2 23
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Metabotropic glutamate receptor 5 Ligand N-(3-acetamidophenyl)... 4 20
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Sigma non-opioid intracellular receptor 1 ligand NCI60_038428 ... 5 9
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [2... 2 4
Substance-K receptor and Substance-P receptor ligand N-[4-[[4-... 1 4
C-C chemokine receptor type 5 ligand N-[(1S)-3-[(3aS,6aR)-5-(2... 1 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 15 24
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 5 3
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... 1 1
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 16 11
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 10 18
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 6
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2,5-dichlor... 3 4
Vasopressin V2 receptor ligand [2-chloro-4-(prop-2-enylamino)p... 3 14
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 18 4
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 6
Substance-P receptor ligand 4-[1-[2-[1-(cyclopropylmethyl)-3-(... 10 6
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 2
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 9 0
Substance-K receptor ligand (5S)-1-(2-cyclopropylethyl)-5-(3,4... 10 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 5 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 3 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 2 0
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Prelamin-A/C and Lysine-specific demethylase 4E inhibitor 4-(4... 2 3
5-hydroxytryptamine receptor 1A ligand U93385 family 4 1
Substance-K receptor and Substance-P receptor ligand N-[(2Z,3R... 26 4
Neuromedin-K receptor ligand (1S,2R)-1-(3,4-dichlorophenyl)-N-... 8 0
Prothrombin inhibitor AGN-PC-09QJ23 family 2 5
Prostaglandin D2 receptor 2 ligand SureCN4942606 family 2 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 6 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 24 11
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 7 4
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 7 31
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 7 16
Mitogen-activated protein kinase 14 inhibitor 4-chloro-N-cyclo... 2 0
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-[... 6 0
Kappa-type opioid receptor ligand 3,4-dichloro-N-[2-[[(1S)-2-[... 1 0
Prothrombin inhibitor SureCN6921523 family 4 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075C6K ... 3 22
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 3
Renin and Potassium voltage-gated channel subfamily H member 2... 3 2
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 2
Peptide deformylase inhibitor (2S)-N-benzoyl-1-[(2R)-2-(cyclop... 2 2
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 6 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 3
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 3
Prolyl endopeptidase and Seprase inhibitor [(2R)-1-[2-[(2,5-di... 3 2
Growth hormone secretagogue receptor type 1 ligand N-[4,6-dich... 2 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
P2X purinoceptor 7 inhibitor AGN-PC-050YNC family 1 6
P2X purinoceptor 7 inhibitor SureCN3726471 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-050YWL family 2 4
P2X purinoceptor 7 inhibitor SureCN3652462 family 5 2
P2X purinoceptor 7 inhibitor SureCN8516206 family 5 1
P2X purinoceptor 7 inhibitor (2S)-N-[[2-chloro-3-(trifluoromet... 3 0
P2X purinoceptor 7 inhibitor SureCN3659568 family 3 0
B1 bradykinin receptor ligand N-[(1R)-1-[4-(3-chloro-2-propano... 1 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-chloro-5-... 3 1
Histamine H3 receptor ligand AGN-PC-0CW63F family 1 1
C-C chemokine receptor type 1 ligand 4-chloro-N-[(2R)-1-[(4S)-... 6 3
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 4
Histamine H3 receptor ligand AGN-PC-01WA6E family 10 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 4
Coagulation factor X inhibitor N-(4-chlorophenyl)-2-[[4-(2-oxo... 2 0
Substance-K receptor and Neuromedin-K receptor ligand SureCN78... 2 4
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
Mu-type opioid receptor ligand CHEMBL303404 family 1 1
Substance-P receptor and Substance-K receptor ligand 2-[3-[1-[... 10 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[5-... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 5
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Kappa-type opioid receptor ligand 2-[2-[bis(methylsulfonyl)ami... 3 1
Urotensin-2 receptor and Kappa-type opioid receptor ligand Sur... 2 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
C-C chemokine receptor type 5 ligand N-benzyl-N-[(3R)-1-[(1S,5... 1 3
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 4 0
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[(3,4-dichlo... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor N-... 9 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor N-... 1 0
Neuromedin-K receptor and Substance-K receptor ligand AGN-PC-0... 2 0
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
C-C chemokine receptor type 5 ligand AC1MHP8Y family 1 0
Interstitial collagenase and 72 kDa type IV collagenase inhibi... 1 1
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 4 6
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor N-[(2S)-1-[[... 1 3
Transient receptor potential M8 protein ligand 1-[(2S)-2-(2-ch... 4 2
C-C chemokine receptor type 2 ligand AGN-PC-00D2HV family 2 2
Voltage-dependent T-type calcium channel subunit alpha-1I and ... 1 0
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 1 0
Voltage-dependent T-type calcium channel subunit alpha-1H and ... 2 0
Putative Bioactive [3-[benzoyl(hydroxy)amino]-1-(3,4-dichlorop... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00285160 CHEMBL1079263 Bioactive 2,3-dichloro-N-(2H-pyran-4-yl)-N-[(3S)-pyrrolidin-3-yl]benzamide
CFAMM00285159 CHEMBL1079264 Bioactive 2,3-dichloro-N-phenyl-N-[(3S)-pyrrolidin-3-yl]benzamide
CFAMM00285149 CHEMBL2337500 Bioactive (3aR,9bS)-6,7-dichloro-1,2,3,3a,4,9b-hexahydropyrrolo[3,4-c]isoquinolin-5-one;hydrochloride
CFAMM00285156 CHEMBL567725 Bioactive SureCN6412100
CFAMM00285168 CHEMBL571536 Bioactive 3,4-dichloro-N-ethyl-2-methyl-N-[(3R)-pyrrolidin-3-yl]benzamide
CFAMM00285132 DNC010654 Investigative Drug PF-18298

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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