CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3145
Family Name Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibitor (r)-2-(2-naphthamido)-3-m-tolylpropanoic Acid Family
No. of Seeds 5 No. of Other Members 23
Family Centroid CFAMM00285354 Functional Category Investigative Drug with Natural Product
Superfamily Kappa-type opioid receptor and Delta-type opioid receptor Binder Superfamily 6
Class Class 884

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
DNA Binder Procarbazine Family 8 358
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Integrin beta-1 Inhibitor R411 Family 33 44
Dopamine reuptake Inhibitor Amineptine Family 2 5
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Neprilysin Inhibitor Thiorphan Family 41 68
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU85053 F... 6 8
Thymidylate synthase Inhibitor Sp-876 Family 7 117
Penicillin-binding protein 1B Inhibitor N-benzoyl-d-alanine Fa... 1 40
Poly [ADP-ribose] polymerase 1 Inhibitor 3,4-dihydro-5-methyl-... 3 2
Integrin alpha-V and Integrin beta-3 Inhibitor Cyclo-[-arg-gly... 5 38
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Integrin beta-3 Inhibitor L-709780 Family 9 10
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Integrin beta-3 Inhibitor DMP-728 Family 3 0
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Trifunctional purine biosynthetic protein adenosine-3 Inhibito... 2 11
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Serine/threonine-protein kinase Chk1 Inhibitor 6-(3-aminopropy... 2 7
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 3 10
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 3 18
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
Angiotensin-converting enzyme inhibitor (S)-1-((S)-5-benzamido... 5 2
Chymotrypsin-like elastase family member 2A and Chymotrypsinog... 2 18
Substance-K receptor ligand 4-(4-methylphenyl)-N-[1-[[(2S)-5-[... 6 0
Coagulation factor X and Cationic trypsin inhibitor AC1L1JML f... 11 32
Neprilysin and Aminopeptidase N inhibitor (2S)-2-[[(2S)-2-[[[a... 13 1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 inhibit... 1 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 3 13
Caspase-1 inhibitor (3S)-3-[[(2S)-4-(2-naphthalen-1-ylethylami... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7285564... 1 2
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN5686807 f... 7 2
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 1
Stromelysin-1 inhibitor 6-(4'-FLUORO-BIPHENYL-4-YL)-4-(3-METHY... 3 0
Caspase-1 inhibitor AGN-PC-075AEI family 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Mitogen-activated protein kinase 14 and Cytochrome P450 2C9 in... 2 0
Endothelin-converting enzyme 1 and Cathepsin D inhibitor N-[(2... 6 2
Beta-secretase 1 inhibitor (2S)-2-[(3R)-3-acetamido-3-(2-methy... 3 0
Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-7-benzamido-N-[... 7 18
Integrin alpha-4 and Integrin beta-7 inhibitor (2S)-2-[(2,6-di... 9 27
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(2,6-di... 2 4
Caspase-1 and Caspase-8 inhibitor N-[(6S)-3-(benzamidomethyl)-... 4 4
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN6949669... 12 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 1 2
Angiotensin-converting enzyme and Angiotensin-converting enzym... 1 0
Calpain-1 catalytic subunit inhibitor Peptidyl alpha-Ketoacid,... 1 0
Neprilysin inhibitor AGN-PC-02K4O6 family 2 0
Neprilysin inhibitor methyl (2S)-4-methyl-2-[[2-(sulfanylmethy... 3 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Breast cancer type 1 susceptibility protein inhibitor (2S)-2-[... 1 0
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 1 0
Coagulation factor X and Coagulation factor VII inhibitor AGN-... 1 2
Mitogen-activated protein kinase 8 inhibitor methyl 2-benzyl-1... 1 2
Receptor-type tyrosine-protein phosphatase C ligand SureCN6261... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00285357 DNC010684 Investigative Drug (R)-2-(2-naphthamido)-3-p-tolylpropanoic acid
CFAMM00285356 DNC010685 Investigative Drug (R)-2-(2-naphthamido)-5-phenylpent-4-ynoic acid
CFAMM00285355 DNC010686 Investigative Drug (R,)-2-(2-naphthamido)-5-phenylpent-4-enoic acid
CFAMM00285354 DNC010682 Investigative Drug (R)-2-(2-naphthamido)-3-m-tolylpropanoic acid
CFAMM00285353 DNC010683 Investigative Drug (R)-3-(2-naphthamido)-4-m-tolylbutanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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