CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3167
Family Name DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)phenol Family
No. of Seeds 4 No. of Other Members 13
Family Centroid CFAMM00285704 Functional Category Investigative Drug
Superfamily Estradiol 17-beta-dehydrogenase 1 and DNA topoisomerase 1 Binder Superfamily
Class Class 1991

Cousin Family NamesSeedsMembers
Histamine N-methyltransferase inhibitor aminoquinoline Amodiaq... 8 23
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Histamine H1 receptor Ligand Doxylamine Family 2 91
Aromatic-L-amino-acid decarboxylase Inhibitor Vitamin B6 Family 6 13
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
DNA Binder Elliptinium Acetate Family 11 116
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Citric Acid family 2 58
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Cytochrome b Inhibitor 2-nonyl-4-hydroxyquinoline N-OXIDE Family 2 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Acetylcholinesterase Inhibitor Velnacrine Family 2 29
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Oestrogen receptor and Estrogen receptor beta Ligand ZK-119010... 2 16
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Oestrogen receptor and Estrogen receptor beta Ligand Estrogen ... 7 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
E3 ubiquitin-protein ligase Mdm2 Inhibitor NSC-66811 Family 4 27
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3,3'-pyrazine-2,5-... 2 14
Indoleamine 2,3-dioxygenase 1 Inhibitor 5-aminoquinolin-8-ol F... 3 16
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 5 69
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapol Family 3 41
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35
Androgen receptor Ligand 11-methyl-6,11-dihydro-5h-benzo[a]car... 7 9
Metabotropic glutamate receptor 5 Ligand 3-hydroxy-5-(2-methyl... 2 1
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 10
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 4
Insulin-like growth factor-binding protein 4 and Insulin-like ... 4 44
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 3 18
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4S,... 5 2
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00CFYH ... 2 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Glucocorticoid receptor ligand 1,1,1-trifluoro-2-[(1-methyl-3,... 3 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 5 8
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
D(4) dopamine receptor ligand AGN-PC-00SXAZ family 2 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Estrogen receptor beta and Estrogen receptor ligand 2-fluoro-4... 1 0
Proto-oncogene tyrosine-protein kinase receptor Ret ligand Sur... 1 1
Steroid hormone receptor ERR1 and Steroid hormone receptor ERR... 1 4
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Platelet-activating factor receptor ligand SureCN9852997 family 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 1 0
Estrogen receptor and Estrogen receptor beta ligand SureCN6841... 2 5
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 5
Nociceptin receptor and Potassium voltage-gated channel subfam... 3 9
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1,1,1... 12 3
Mitogen-activated protein kinase 14 inhibitor (4E)-4-[3-amino-... 1 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 7 1
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 2 4
Nuclear receptor ROR-gamma and Induced myeloid leukemia cell d... 1 1
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 2 8
Androgen receptor ligand SureCN1990713 family 1 0
Fatty acid synthase inhibitor SureCN4564627 family 1 2
Poly [ADP-ribose] polymerase 1 inhibitor N-(6-oxo-5H-benzo[c][... 1 3
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-074... 1 0
(E)-3-(2-hydroxyphenyl)-1-pyridin-4-ylprop-2-en-1-one NP (e)-3... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00285705 DNC010795 Investigative Drug 3-(6-phenyl-2,4'-bipyridin-4-yl)phenol
CFAMM00285690 DNC010788 Investigative Drug 3,3'-(4-phenylpyridine-2,6-diyl)diphenol
CFAMM00285704 DNC010793 Investigative Drug 3-(4-phenyl-2,4'-bipyridin-6-yl)phenol
CFAMM00285703 DNC010790 Investigative Drug 3-(2,6-diphenylpyridin-4-yl)phenol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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