CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3178
Family Name NF-kappa-B Inhibitor Rocaglamide Family
No. of Seeds 8 No. of Other Members 8
Family Centroid CFAMM00285955 Functional Category Investigative Drug
Superfamily NF-kappa-B Inhibitor Rocaglamide Superfamily
Class Class 2689

Cousin Family NamesSeedsMembers
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
DNA topoisomerase 2-beta Inhibitor TOP-53 Family 2 12
Free fatty acid receptor 1 Ligand TAK-875 Family 2 54
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Endothelin-1 receptor Ligand PD156707 Family 41 211
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Androgen receptor Ligand Palodesangren E Family 12 43
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 6 6
Squalene synthase inhibitor (6R,7R)-1-[(4S,5R)-4-acetyloxy-5-m... 8 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 4
Endothelin-1 receptor ligand SureCN8117947 family 1 3
Eukaryotic initiation factor 4A-I inhibitor methyl (1R,2R,3S,3... 12 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00285959 CHEMBL2170561 Bioactive (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6-[[(2S,6S)-6-(hydroxymethyl)-1,4-dioxan-2-yl]oxy]-8-methoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide
CFAMM00285948 CHEMBL2170703 Bioactive (1R,2R,3S,3aR,8bS)-3a-(4-cyanophenyl)-1,8b-dihydroxy-6,8-dimethoxy-N,N-dimethyl-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide
CFAMM00285976 CHEMBL394528 Bioactive Aglafoline
CFAMM00285958 CHEMBL2170562 Bioactive (1R,2R,3S,3aR,8bS)-6-cyano-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide
CFAMM00285957 CHEMBL2170563 Bioactive (1R,2R,3S,3aR,8bS)-6-chloro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide
CFAMM00285937 CHEMBL2058177 Bioactive (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide
CFAMM00285960 CHEMBL2170560 Bioactive (1R,2R,3S,3aR,8bS)-6-[[(2S,3R,6R)-6-[(1S)-1,2-dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide
CFAMM00285955 DNC010821 Investigative Drug ROCAGLAMIDE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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