CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID319
Family Name D(4) dopamine receptor Ligand Fauc 113 Family
No. of Seeds 14 No. of Other Members 96
Family Centroid CFAMM00187182 Functional Category Investigative Drug
Superfamily D(4) dopamine receptor and cAMP-specific 3',5'-cyclic phosphodiesterase 4B Binder Superfamily
Class Class 1532

Cousin Family NamesSeedsMembers
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Acetylcholinesterase Inhibitor Tacrine Family 12 515
D(2) dopamine receptor Ligand Sertindole Family 3 173
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
PF-4217903 family 14 65
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Prothrombin Inhibitor 4-[3-(4-chlorophenyl)-1h-pyrazol-5-yl]pi... 7 39
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A1 and Adenosine receptor A2a Ligand FK-838... 4 19
Metabotropic glutamate receptor 5 Ligand 3-(3-pyridin-2-yl-pyr... 4 24
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 6
Mitogen-activated protein kinase kinase kinase 8 and Stromelys... 6 53
Calcium-activated potassium channel subunit alpha-1 Ligand 1-(... 3 3
Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... 2 16
Kappa-type opioid receptor and Potassium voltage-gated channel... 10 10
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Cytochrome P450 3A4 Inhibitor 5-(2-phenethylpiperazin-1-yl)-1h... 12 35
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 9 22
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 6
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YT9... 28 20
Corticotropin-releasing factor receptor 1 ligand 3,7-dimethyl-... 3 4
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 4 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YUB... 2 0
Acetylcholinesterase and Cholinesterase inhibitor 3,8-DIAMINO-... 2 3
Smoothened homolog inhibitor AC1P6IWE family 1 0
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 1
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Tyrosine-protein kinase ITK/TSK inhibitor (3Z)-3-(6-methylindo... 2 40
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00AP1L ... 14 7
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 1
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 6
Mitogen-activated protein kinase kinase kinase 8 inhibitor Sur... 11 2
Alpha-1A adrenergic receptor and D(2) dopamine receptor ligand... 1 0
Motilin receptor ligand SureCN2004322 family 2 1
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 3 0
Casein kinase I isoform delta and Casein kinase I isoform epsi... 1 0
Glucocorticoid receptor ligand 1-[(4aS)-6-(4-tert-butylphenyl)... 27 3
Glucocorticoid receptor ligand 6-benzyl-1-(4-fluorophenyl)-4a-... 2 0
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Cannabinoid receptor 1 ligand AGN-PC-07NHJ5 family 9 1
Sigma non-opioid intracellular receptor 1 ligand 1-phenyl-4-(2... 1 0
Progesterone receptor ligand AGN-PC-074LWG family 1 1
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 3 22
Nociceptin receptor ligand SureCN3543370 family 1 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 6 4
Transient receptor potential cation channel subfamily V member... 1 0
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 3 2
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
TGF-beta receptor type-1 ligand 6-bromo-4-(2-(6-methylpyridin-... 1 3
TGF-beta receptor type-1 ligand SureCN373106 family 4 1
Extracellular calcium-sensing receptor ligand SureCN2220343 fa... 1 0
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 1 4
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 0
1,5-dioxidopyrrolo[3,2-c]pyridin-5-ium NP Agn-pc-0639xa Family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00187224 CHEMBL160626 Bioactive SureCN5021444
CFAMM00187190 CHEMBL160454 Bioactive [3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]pyrazolo[1,5-a]pyridin-7-yl]-trimethylsilane
CFAMM00187232 CHEMBL210955 Bioactive AGN-PC-0762PZ
CFAMM00187257 CHEMBL155913 Bioactive 3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-7-phenylpyrazolo[1,5-a]pyridine
CFAMM00187174 CHEMBL156851 Bioactive 3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-7-ethynyl-2-methylpyrazolo[1,5-a]pyridine
CFAMM00187236 CHEMBL160932 Bioactive 3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-2-methylpyrazolo[1,5-a]pyridine-7-carbonitrile
CFAMM00187242 CHEMBL7506 Bioactive 3-[[4-(2-chlorophenyl)piperazin-1-yl]methyl]pyrazolo[1,5-a]pyridine
CFAMM00187199 CHEMBL160952 Bioactive 3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-7-ethynylpyrazolo[1,5-a]pyridine
CFAMM00187213 CHEMBL269202 Bioactive 3-[[4-(3-chlorophenyl)piperazin-1-yl]methyl]pyrazolo[1,5-a]pyridine
CFAMM00187219 CHEMBL432059 Bioactive 6-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]pyrazolo[1,5-a]pyridine
CFAMM00187158 CHEMBL423247 Bioactive 3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-7-methylpyrazolo[1,5-a]pyridine
CFAMM00187212 CHEMBL310843 Bioactive FAUC 213
CFAMM00187240 CHEMBL7508 Bioactive 3-[[4-(4-iodophenyl)piperazin-1-yl]methyl]pyrazolo[1,5-a]pyridine
CFAMM00187182 DNC000641 Investigative Drug FAUC 113

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27746 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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