CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3197
Family Name 5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-(piperidin-1-yl)butyl)urea Family
No. of Seeds 20 No. of Other Members 67
Family Centroid CFAMM00286238 Functional Category Investigative Drug with Natural Product
Superfamily 5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-(piperidin-1-yl)butyl)urea Superfamily
Class Class 1625

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Sodium channel Ligand iminostilbene derivative (tricyclic stru... 2 46
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Histamine H1 receptor Ligand Epinastine Family 2 26
Histamine H1 receptor Ligand Antazoline Family 5 57
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
D(2) dopamine receptor Ligand Nomifensine Family 6 100
Motilin receptor Ligand GSK962040 Family 30 457
Tumor necrosis factor Inhibitor Pirfenidone Family 2 38
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Nociceptin receptor Ligand J-113397 Family 3 14
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Delta-type opioid receptor Ligand Sb 227122 Family 7 5
NMDA receptor Ligand Aptiganel Hcl Family 2 82
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 19 186
Urokinase-type plasminogen activator Inhibitor N-(1-adamantyl)... 2 15
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 5 65
Tyrosine-protein phosphatase non-receptor type 1 Ligand [[4-(a... 1 7
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 9 19
5-hydroxytryptamine receptor 5A Ligand N,4-dimethyl-3,4-dihydr... 8 51
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 14 78
Androgen receptor Ligand LG-121071 Family 8 32
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-chloro-phenyl)... 5 50
Transient receptor potential cation channel subfamily V member... 6 33
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-[2-(... 5 72
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 3-(3-p... 7 17
Transient receptor potential cation channel subfamily V member... 4 38
Cholecystokinin receptor type A Ligand L-708474 Family 14 82
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 8 32
Androgen receptor Ligand YM-175735 Family 30 129
Aromatase Inhibitor 3-amino-4'-amino-trans-stilbene Family 5 47
Histamine H3 receptor Ligand N-benzyl-4-cyclopentylpiperazine-... 3 19
Cannabinoid receptor 1 Ligand 1-(bis(4-chlorophenyl)methyl)-3-... 4 44
Cannabinoid receptor 1 Ligand 1-[bis(4-iodophenyl)methyl]-3-(4... 4 13
Kinesin-like protein KIF11 Inhibitor N-{4'-[(trifluoromethyl)s... 3 1
Kinesin-like protein KIF11 Inhibitor N-(4'-bromo-3,3'-difluoro... 2 0
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 7 134
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 2 9
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 13
Dipeptidyl peptidase 4 Inhibitor (3s,4r)-3-butyl-1-phenylpiper... 2 40
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Histamine H3 receptor Ligand (r)-1-(4-nitrophenethyl)-2-methyl... 16 38
Phospholipase D1 Inhibitor Halopemide Family 17 111
Fructose-1,6-bisphosphatase 1 Inhibitor 1-(4-aminophenylsulfon... 2 1
Fatty-acid amide hydrolase 1 Inhibitor 1-biphenyl-4-ylmaleimid... 2 11
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 2 7
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 42
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
Sodium-dependent serotonin transporter Inhibitor Irindalone Fa... 16 9
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 45
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 12 4
D(2) dopamine receptor Ligand PD-168077 Family 6 5
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 4 24
Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-a... 1 15
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 2
Tyrosinase Inhibitor 1-hydroxy-3-phenylurea Family 2 10
Tyrosinase Inhibitor 1-hydroxy-3-(4-(trifluoromethyl)phenyl)ur... 2 3
Trypsin Inhibitor 1,3-di-p-tolyl-[1,3]diazetidine-2,4-dione Fa... 2 16
DNA topoisomerase Inhibitor 6-p-tolylamino-1h-pyrimidine-2,4-d... 3 17
DNA topoisomerase Inhibitor 6-(indan-5-ylamino)-1h-pyrimidine-... 2 0
DNA topoisomerase Inhibitor 6-(naphthalen-2-ylamino)-1h-pyrimi... 2 1
DNA topoisomerase Inhibitor 6-(3-iodo-phenylamino)-1h-pyrimidi... 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZBI0 family 2 16
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C8 inhib... 6 5
Growth hormone secretagogue receptor type 1 ligand AGN-PC-07ZB... 2 2
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 2 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 10
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 5 2
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 5 5
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 4
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04TGG7 family 2 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
B2 bradykinin receptor ligand AGN-PC-074WA4 family 2 3
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 5 14
Inosine-5'-monophosphate dehydrogenase inhibitor 1-[2-[3-[(E)-... 3 6
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
Melanin-concentrating hormone receptor 1 ligand 1-[(6S)-6-(3-c... 7 18
Melanin-concentrating hormone receptor 1 ligand 3-(3-chloro-4-... 8 24
Melanin-concentrating hormone receptor 1 ligand 3-(3-bromophen... 4 0
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Survival motor neuron protein and 15-hydroxyprostaglandin dehy... 1 4
C-C chemokine receptor type 3 ligand SureCN6703027 family 2 1
Mitogen-activated protein kinase 1 and M17 leucyl aminopeptida... 1 21
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
C-C chemokine receptor type 2 and C-C chemokine receptor type ... 2 8
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 6
D(3) dopamine receptor and D(2) dopamine receptor ligand 3-[4-... 4 23
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 1-(2-c... 1 1
Cathepsin K and Cathepsin L1 inhibitor 1-[(2S)-1-[[cyano(methy... 2 1
Melanin-concentrating hormone receptor 1 ligand 1-[[4-[4-(3-cy... 14 23
Melanin-concentrating hormone receptor 1 ligand 1-[2-[4-(3-cya... 3 2
Ribosyldihydronicotinamide dehydrogenase [quinone] and Melaton... 1 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 0
Bifunctional epoxide hydrolase 2 inhibitor 1-(2,3,4-trifluorop... 2 2
Bifunctional epoxide hydrolase 2 inhibitor 1-(2-adamantyl)-3-(... 2 4
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 2 6
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
Melanin-concentrating hormone receptor 1 ligand SureCN3845324 ... 7 4
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
C-C chemokine receptor type 3 and Sodium-dependent serotonin t... 12 2
Transient receptor potential cation channel subfamily V member... 9 38
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-cyc... 2 1
Sigma non-opioid intracellular receptor 1 ligand 1-[4-[1-adama... 4 23
D(3) dopamine receptor and D(2) dopamine receptor ligand RGH-1... 8 0
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
Bifunctional epoxide hydrolase 2 inhibitor 1-(3-acetylphenyl)-... 1 3
Regulator of G-protein signaling 4 and Regulator of G-protein ... 1 5
Melanin-concentrating hormone receptor 1 ligand SureCN14265866... 11 2
D(2) dopamine receptor and Potassium voltage-gated channel sub... 1 1
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 2 17
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 2
Melanin-concentrating hormone receptor 1 ligand SureCN14101999... 3 0
Nociceptin receptor ligand 2-[3-[1-[(1R)-1,2-dihydroacenaphthy... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 13
5-hydroxytryptamine receptor 7 ligand 1-[2-(4-nitrophenyl)phen... 1 0
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(cyanomethyl)-... 1 6
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00CYMY ... 1 0
Inosine-5'-monophosphate dehydrogenase inhibitor 1-(3,4-dichlo... 1 1
C-C chemokine receptor type 3 ligand 1-(3-acetylphenyl)-3-[3-[... 9 1
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor 1-(3,5... 2 0
Translocator protein inhibitor CHEMBL2332254 family 6 1
Receptor activity-modifying protein 1 and Calcitonin gene-rela... 2 4
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
Histamine H3 receptor and Histamine receptor H3 ligand N-[4-[3... 5 1
Histamine H3 receptor and Histamine receptor H3 ligand 1-cyclo... 3 4
Histamine H3 receptor and Histamine receptor H3 ligand 1-(3,5-... 4 0
Substance-P receptor ligand (2R,3R)-2-benzhydryl-N-(2-iodophen... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 1
C-X-C chemokine receptor type 3 and Muscarinic acetylcholine r... 1 0
Neuropeptide Y receptor type 5 ligand 3-[1-(3,5-difluorophenyl... 4 0
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
5-hydroxytryptamine receptor 7 ligand 2-[4-[4-(2-oxo-1,3,4,5-t... 1 0
Chitin synthase 1 inhibitor AC1O53V7 family 9 0
Substance-P receptor ligand N-[[3,5-bis(trifluoromethyl)phenyl... 1 0
C-C chemokine receptor type 3 ligand AGN-PC-073RIP family 2 4
Tryptase alpha/beta-1 and Tryptase delta inhibitor AGN-PC-03J1... 4 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Tryptase alpha/beta-1 and Tryptase delta inhibitor SureCN75047... 4 2
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
Melanin-concentrating hormone receptor 1 ligand SureCN13451707... 3 1
C-C chemokine receptor type 3 ligand AGN-PC-075BAT family 1 0
Dipeptidyl peptidase 4 inhibitor 4-[[(3S,5S)-5-[(2S)-2-cyanopy... 4 12
C-C chemokine receptor type 5 ligand AC1L9YPM family 3 6
Somatostatin receptor type 1 ligand AGN-PC-078XL6 family 9 9
Sodium-dependent noradrenaline transporter inhibitor SureCN408... 5 12
Transient receptor potential cation channel subfamily V member... 1 1
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 1 0
Neuropeptide Y receptor type 5 ligand SureCN6214451 family 3 1
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 4 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRYI family 2 0
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 3 5
Melanin-concentrating hormone receptor 1 and Alpha-1A adrenerg... 1 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZK family 3 0
5-hydroxytryptamine receptor 4 ligand 2-oxo-N-[(1R,5S)-8-(2-pi... 13 5
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-[2-... 3 1
D(1A) dopamine receptor and D(3) dopamine receptor ligand 1-[4... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 4 3
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 1 0
Potassium voltage-gated channel subfamily H member 2 and D(3) ... 3 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
ATP-binding cassette sub-family C member 9 and ATP-sensitive i... 1 2
DNA polymerase III PolC-type inhibitor HB-EMAU family 17 7
C-X-C chemokine receptor type 3 ligand 3-[3,5-bis(trifluoromet... 3 5
Sterol O-acyltransferase 1 inhibitor SureCN7565101 family 2 10
Mu-type opioid receptor ligand 1-[[(3S)-2-[[(2R)-1-[(4-cyanoph... 1 0
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN9352718 f... 2 3
Mu-type opioid receptor ligand N-[4-[[(2R)-2-[[[(3S)-3-[(pheny... 1 0
Reverse transcriptase/RNaseH inhibitor (4S)-6-fluoro-4-(3-meth... 7 1
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN13328411 ... 4 2
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2,6-di(propa... 7 2
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN9614694 f... 3 14
Melanin-concentrating hormone receptor 1 ligand N-[1-[3-(4-chl... 1 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 3
Mu-type opioid receptor ligand 1-phenyl-3-[[(3S)-2-[[(2R)-1-(t... 1 1
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2,6-di(propa... 2 0
Squalene monooxygenase inhibitor 3-[[[(E)-6,6-dimethylhept-2-e... 1 0
Extracellular calcium-sensing receptor ligand 478963-46-1 family 2 2
Metabotropic glutamate receptor 2 ligand 4-[4-(methylamino)phe... 1 4
Cytochrome P450 2C9 and Cytochrome P450 2D6 inhibitor N'-(4-he... 1 0
Dihydrofolate reductase inhibitor 5-[[4-(dimethylamino)phenyl]... 1 0
1,3-diazatricyclo[3.3.1.1~3,7~]decan-6-one NP ZINC19320094 Family 6 0
NP (1r,5r)-n-(naphthalen-1-yl)-8-oxo-4,5,6,8-tetrahydro-1h-1,5... 2 0
3,3,5,5-tetramethyl-N-phenyl-1,2,4,6,7,8-hexahydronaphthalen-2... 2 0
2,8-dimethyl-N-phenyl-1,2,3,4,4a,9b-hexahydropyrido[4,3-b]indo... 4 2
4,5,6,8-tetrahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocine-3... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00286192 CHEMBL1818393 Bioactive 1-(2-adamantyl)-3-(4-cyanophenyl)urea
CFAMM00286167 CHEMBL1360431 Bioactive 1-cyclohexyl-3-[4-(propan-2-yl)phenyl]urea
CFAMM00286199 CHEMBL176077 Bioactive 1-[(1R,2S)-2-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]-3-(2-methylphenyl)urea
CFAMM00286241 CHEMBL2031932 Bioactive 1-cyclohexyl-3-(4-hexylphenyl)urea
CFAMM00286255 CHEMBL362466 Bioactive 1-[(1R,2S)-2-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]-3-phenylurea
CFAMM00286219 CHEMBL2031927 Bioactive 1-(cyclohexylmethyl)-3-(4-propan-2-ylphenyl)urea
CFAMM00286166 CHEMBL193330 Bioactive 1-(2-fluorophenyl)-3-[(1R,2S)-2-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]urea
CFAMM00286218 CHEMBL1672132 Bioactive 1-[(1S,2R)-2-phenylcyclopropyl]-3-(1-phenylpiperidin-4-yl)urea
CFAMM00286246 CHEMBL364673 Bioactive 1-(5-fluoro-2-methylphenyl)-3-[(1R,2S)-2-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]urea
CFAMM00286224 CHEMBL2387294 Bioactive 1,3-bis[4-[2-(dimethylamino)ethyl]phenyl]urea
CFAMM00286172 CHEMBL364263 Bioactive 1-(3-fluorophenyl)-3-[(1R,2S)-2-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]urea
CFAMM00286230 CHEMBL194141 Bioactive 1-(4-fluorophenyl)-3-[(1R,2S)-2-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]urea
CFAMM00286179 CHEMBL2029374 Bioactive 1-(4-tert-butylphenyl)-3-cyclohexylurea
CFAMM00286210 CHEMBL1080076 Bioactive AGN-PC-07ZBSR
CFAMM00286185 CHEMBL2029927 Bioactive 1-phenyl-3-[3-[2-(4-phenylpiperazin-1-yl)ethyl]phenyl]urea
CFAMM00286236 CHEMBL175679 Bioactive 1-[(1R,2S)-2-[(4-benzylpiperidin-1-yl)methyl]cyclohexyl]-3-(3-cyanophenyl)urea
CFAMM00286205 DNC014629 Investigative Drug 1-(3,3-Diphenyl-allyl)-3-m-tolyl-urea
CFAMM00286238 DNC010890 Investigative Drug 1-(biphenyl-4-yl)-3-(4-(piperidin-1-yl)butyl)urea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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