CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3207
Family Name Urotensin-2 receptor Ligand Palosuran Family
No. of Seeds 4 No. of Other Members 4
Family Centroid CFAMM00286301 Functional Category Investigative Drug
Superfamily Lethal factor and Urotensin-2 receptor Binder Superfamily
Class Class 1856

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Saquinavir Family 64 428
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
D(2) dopamine receptor Ligand Sertindole Family 3 173
Histamine H1 receptor Ligand Triprolidine Family 19 316
Transient receptor potential cation channel subfamily V member... 15 158
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Neuromedin-K receptor Ligand SB222200 Family 17 235
Glucagon receptor Ligand Dwlip-gcgrrx Family 5 26
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Amg 423 family 7 47
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Lethal factor Inhibitor N,n'-bis(4-amino-2-methylquinolin-6-yl... 2 11
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 43 17
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 9
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Sodium-dependent serotonin transporter Inhibitor 6-nitroquipaz... 18 21
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Amine oxidase [flavin-containing] A Inhibitor 3-benzyl-n-(2-mo... 2 3
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
5-hydroxytryptamine receptor 3A and D(2) dopamine receptor Lig... 1 0
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-(4-cy... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Cathepsin K and Potassium voltage-gated channel subfamily H me... 5 1
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 13 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Histamine H4 receptor ligand 4-[(3R)-3-(methylamino)pyrrolidin... 7 6
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Cannabinoid receptor 2 ligand 1-[[4-[5-fluoro-6-(piperidin-1-y... 21 2
Melanin-concentrating hormone receptor 2 ligand N,N-dimethyl-3... 2 2
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 2
Melanin-concentrating hormone receptor 1 ligand SureCN6198980 ... 13 0
Monoglyceride lipase and Fatty-acid amide hydrolase 1 inhibito... 11 15
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Neuromedin-K receptor and Potassium voltage-gated channel subf... 13 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 0
Fatty-acid amide hydrolase 1 inhibitor 1-[3-[4-(6-phenylhexyl)... 1 0
Motilin receptor ligand SureCN2768052 family 3 0
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 7 7
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 5 0
Cholinesterase and Acetylcholinesterase inhibitor [2,2-dimethy... 2 0
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
CGMP-dependent protein kinase inhibitor AGN-PC-078XQ0 family 1 1
Corticotropin-releasing factor receptor 1 ligand 5-N,5-N-bis(c... 2 0
N-formyl peptide receptor 2 ligand 1-(1-methyl-3-oxo-5-propan-... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00286301 DNC010935 Investigative Drug PALOSURAN
CFAMM00286300 DNC013697 Investigative Drug PF-622

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26233 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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