CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3214
Family Name Prostaglandin G/H synthase 1 Inhibitor 1-(4-aminosulfonylphenyl)-2-(4-pyridyl)acetylene Family
No. of Seeds 3 No. of Other Members 18
Family Centroid CFAMM00286412 Functional Category Investigative Drug
Superfamily Plasminogen and Prostaglandin G/H synthase 1 Binder Superfamily
Class Class 433

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family 2 99
Solute carrier family 12 member 1 Inhibitor Torasemide Family 13 75
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 5 60
Rho-associated protein kinase 1 Inhibitor Rho-kinase Inhibitor... 6 39
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-(4-phenylb... 6 32
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Plasminogen and Urokinase-type plasminogen activator Inhibitor... 3 26
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 2-(4-... 8 25
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 22
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(n-o... 3 12
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(met... 4 15
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(cya... 4 4
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Prostaglandin G/H synthase 2 Inhibitor 1-(4-(methylsulfonyl)ph... 1 2
Motilin receptor and Cytochrome P450 2D6 ligand 7-[[6-(4-chlor... 2 1
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 10 2
Thromboxane-A synthase inhibitor 4-chloro-N-[8-pyridin-3-yl-5-... 1 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 5 10
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 3 7
Nicotinamide phosphoribosyltransferase and Prelamin-A/C inhibi... 1 0
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6
5-hydroxytryptamine receptor 2A ligand SureCN5215979 family 2 10
5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3
5-hydroxytryptamine receptor 6 and Muscarinic acetylcholine re... 7 3
5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... 8 4
Carbonic anhydrase 12 and Carbonic anhydrase 9 inhibitor 4-(4-... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
Metabotropic glutamate receptor 5 ligand AGN-PC-00CRVW family 1 0
Presenilin-1 and Presenilin-2 inhibitor AGN-PC-050UV6 family 2 2
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 7 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 5 2
5-hydroxytryptamine receptor 7 ligand 6-[(2R)-2-[2-(4-methylpi... 1 0
Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 3 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1,1,1... 12 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor [1-[4... 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Nuclear receptor ROR-gamma and Prelamin-A/C ligand 13463-41-7 ... 1 7
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[4-(... 3 0
Cytochrome P450 3A4 inhibitor N-[2-fluoro-4-(4-fluorophenyl)ph... 2 1
Kinesin-like protein KIF11 inhibitor AGN-PC-077SFB family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00286412 DNC013539 Investigative Drug 1-(4-aminosulfonylphenyl)-2-(4-pyridyl)acetylene
CFAMM00286411 DNC013538 Investigative Drug 1-(4-aminosulfonylphenyl)-2-(2-pyridyl)acetylene
CFAMM00286402 DNC010952 Investigative Drug 4-Benzythiopyridine-3-sulfonamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27515 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543