CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3216
Family Name Cytochrome P450 3A4 Inhibitor 5-(2-phenethylpiperazin-1-yl)-1h-indazole Family
No. of Seeds 12 No. of Other Members 35
Family Centroid CFAMM00286492 Functional Category Investigative Drug
Superfamily Cytochrome P450 3A4 and Acetylcholinesterase Binder Superfamily
Class Class 826

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Transient receptor potential cation channel subfamily V member... 12 108
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
NKP-1339 family 3 7
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
Prothrombin Inhibitor 4-[3-(4-chlorophenyl)-1h-pyrazol-5-yl]pi... 7 39
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
Acetylcholinesterase Inhibitor 3-[2-(1-benzyl-piperidin-4-yl)-... 2 9
Methionine aminopeptidase 2 Inhibitor 5-p-tolyl-1h-[1,2,3]tria... 3 20
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 6
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 19 12
Calcium-activated potassium channel subunit alpha-1 Ligand 1-(... 3 3
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand N-(1h... 2 12
Kappa-type opioid receptor and Potassium voltage-gated channel... 10 10
5-hydroxytryptamine receptor 6 Ligand 4-(piperazin-1-yl)-3-tos... 18 75
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Serine/threonine-protein kinase 17A and Myosin light chain kin... 3 7
Tyrosine-protein kinase ITK/TSK inhibitor (3Z)-3-(6-methylindo... 2 40
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 5 11
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00AP1L ... 14 7
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 18
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
cAMP-dependent protein kinase catalytic subunit PRKX and Ribos... 1 2
cAMP-dependent protein kinase catalytic subunit PRKX and Ribos... 1 1
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
C-C chemokine receptor type 3 ligand 1-(3-chloro-2H-indazol-5-... 1 1
Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... 4 5
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 6
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 1
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 3 0
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 5 0
Glucocorticoid receptor ligand 6-benzyl-1-(4-fluorophenyl)-4a-... 2 0
Sigma non-opioid intracellular receptor 1 ligand 1-phenyl-4-(2... 1 0
Histone deacetylase 1 inhibitor N-hydroxy-N',N'-bis[2-(1H-inda... 1 0
Cell division cycle 7-related protein kinase and Dual specific... 3 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Aurora kinase B and Aurora kinase A inhibitor SureCN5594082 fa... 2 3
Aurora kinase B and Aurora kinase A inhibitor N-[3-[(E)-2-[5-(... 1 0
Microtubule-associated protein tau inhibitor CHEMBL1544706 family 1 0
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
Rho-associated protein kinase 2 and Cytochrome P450 3A4 inhibi... 3 5
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 7
P2X purinoceptor 7 inhibitor N-cyano-N'-(2-methylphenyl)-4-[2-... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00286450 CHEMBL224510 Bioactive AGN-PC-0D4HQF
CFAMM00286491 CHEMBL1169916 Bioactive SureCN2258781
CFAMM00286469 CHEMBL224594 Bioactive AGN-PC-035SXO
CFAMM00286475 CHEMBL1172525 Bioactive SureCN2254592
CFAMM00286474 CHEMBL1172524 Bioactive SureCN2252433
CFAMM00286480 CHEMBL224535 Bioactive N-[1-[(4-aminophenyl)methyl]piperidin-3-yl]-1H-indazol-5-amine
CFAMM00286472 CHEMBL1172526 Bioactive SureCN2257310
CFAMM00286465 CHEMBL388516 Bioactive SureCN660050
CFAMM00286456 DNC013674 Investigative Drug D-189
CFAMM00286492 DNC010967 Investigative Drug 5-(2-phenethylpiperazin-1-yl)-1H-indazole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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