CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3226
Family Name Kinesin-like protein KIF11 Inhibitor 2-(trifluoromethyl)-9h-carbazole Family
No. of Seeds 5 No. of Other Members 0
Family Centroid CFAMM00286635 Functional Category Investigative Drug
Superfamily D(1B) dopamine receptor Ligand LE-300 Superfamily
Class Class 1105

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
Acetylcholinesterase Inhibitor Tacrine Family 12 515
D(2) dopamine receptor Ligand Sertindole Family 3 173
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 3 15
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
Fatty acid-binding protein, adipocyte and Fatty acid-binding p... 3 11
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Indoleamine 2,3-dioxygenase 1 Inhibitor N-[2-(indol-3-yl)ethyl... 2 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... 2 16
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 1
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 10 18
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 7,12-d... 1 0
Arachidonate 15-lipoxygenase Inhibitor PD-146176 Family 1 3
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 3-fluoro-5-(2-methylq... 3 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Trypsin Inhibitor 4-(5-nitro-indol-1-ylmethyl)-benzamidine Family 2 0
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
Progesterone receptor and Androgen receptor ligand 5-[4-[(Z)-C... 2 5
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 3
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 4 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 5 6
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 7 1
Capsid scaffolding protein inhibitor AC1O583J family 5 1
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 1
5-hydroxytryptamine receptor 1D ligand AGN-PC-01NTBS family 1 1
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 5
Prostaglandin G/H synthase 2 inhibitor SureCN6345015 family 6 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 1
Kinesin-like protein KIF11 inhibitor 9-(trifluoromethyl)-1,2,4... 4 1
Cytochrome P450 2C19 inhibitor CHEMBL1449918 family 1 0
Indoles Metabolite Ethyl 3-methyl-9H-carbazole-9-carboxylate F... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00286635 DNC011003 Investigative Drug 2-(trifluoromethyl)-9H-carbazole
CFAMM00286634 DNC011007 Investigative Drug 2-(difluoromethyl)-9H-carbazole
CFAMM00286633 DNC011018 Investigative Drug 9-methyl-2-(trifluoromethyl)-9H-carbazole
CFAMM00286637 DNC010998 Investigative Drug 2-methyl-6-(trifluoromethyl)-9H-carbazole
CFAMM00286636 DNC010999 Investigative Drug 3-(trifluoromethyl)-9H-carbazole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26230 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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