CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3230
Family Name Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 11B1, mitochondrial Inhibitor 4'-(pyridin-4-ylmethyl)biphenyl-3,4-diamine Family
No. of Seeds 2 No. of Other Members 4
Family Centroid CFAMM00286697 Functional Category Investigative Drug
Superfamily Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 11B1, mitochondrial Inhibitor 4'-(pyridin-4-ylmethyl)biphenyl-3,4-diamine Superfamily
Class Class 1022

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Amrino... 3 55
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Neuronal acetylcholine receptor subunit alpha-4 Ligand Varenic... 3 54
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Muscarinic acetylcholine receptor M4 Ligand Tropicamide Family 3 73
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Thromboxane A2 receptor Ligand Ridogrel Family 7 83
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
26S proteasome Inhibitor Bortezomib Family 7 65
Histamine H1 receptor Ligand (s)-(+)-dimethindene Maleate Family 6 12
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
G protein-activated inward rectifier potassium channel 4 Ligan... 3 48
Transient receptor potential cation channel subfamily V member... 15 158
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Neuromedin-K receptor Ligand SB222200 Family 17 235
Thromboxane A2 receptor Ligand Bibv 308 Family 14 40
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Coagulation factor X Inhibitor Otamixaban Family 9 21
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
Histone deacetylase 1 Inhibitor Pyroxamide Family 4 13
Amg 423 family 7 47
ABC294640 family 5 75
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Aromatase Inhibitor Rogletimide Family 1 2
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 22
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 5
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Histone deacetylase Inhibitor ST-5732 Family 8 6
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Transient receptor potential cation channel subfamily V member... 3 1
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 3 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
Epidermal growth factor receptor ligand AGN-PC-07Q1HU family 4 17
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 1
Thromboxane-A synthase and Thromboxane A2 receptor ligand (E)-... 2 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 13 1
Cathepsin K inhibitor SureCN2155973 family 3 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Platelet-activating factor receptor ligand YM-461 family 1 11
Metabotropic glutamate receptor 2 and Metabotropic glutamate r... 5 3
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Prostaglandin E synthase inhibitor AGN-PC-09QHBK family 3 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 2
Neuropeptide Y receptor type 5 ligand (5E)-5-[(4S,5S)-4-(4-flu... 18 3
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Cell division cycle 7-related protein kinase and Protein DBF4 ... 1 5
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 4
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 8 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 3 2
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
G-protein coupled bile acid receptor 1 ligand 1-[4-[(1R,3E)-1-... 1 1
Cathepsin K inhibitor AGN-PC-046RTV family 4 1
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
C-C chemokine receptor type 2 ligand SureCN5947024 family 11 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 1 2
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Histone deacetylase 1 inhibitor AGN-PC-0456JP family 1 0
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
Neuropeptide Y receptor type 5 ligand SureCN4464548 family 17 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1
Thymidylate synthase inhibitor AGN-PC-00EUGY family 2 7
Rho-associated protein kinase 2 and Rho-associated protein kin... 1 0
D(4) dopamine receptor ligand SureCN4006627 family 1 0
NADPH oxidase 4 inhibitor AGN-PC-09M5SP family 1 1
DNA polymerase beta inhibitor AE-406/41056622 family 1 1
Trypsin-1 and Coagulation factor X inhibitor 3-[5-(4-carbamimi... 1 0
Potassium voltage-gated channel subfamily A member 5 and Inter... 2 0
Potassium voltage-gated channel subfamily H member 2 ligand 1-... 1 0
Cytochrome P450 3A4 inhibitor N-[2-fluoro-4-(4-fluorophenyl)ph... 2 1
Kinesin-like protein KIF11 inhibitor AGN-PC-077SFB family 1 0
Putative NP ZINC38570085 Family 14 0
Putative NP ZINC03999850 Family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00286697 DNC011036 Investigative Drug 4'-(Pyridin-4-ylmethyl)biphenyl-3,4-diamine
CFAMM00286700 DNC011105 Investigative Drug N-(4'-Isonicotinoylbiphenyl-3-yl)acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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