CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3232
Family Name 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 2A Ligand 1,6-bis(4-phenylpiperazin-1-yl)hexane Family
No. of Seeds 5 No. of Other Members 47
Family Centroid CFAMM00286730 Functional Category Investigative Drug
Superfamily 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 2A Binder Superfamily 2
Class Class 2707

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Sodium channel Ligand iminostilbene derivative (tricyclic stru... 2 46
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Mu-type opioid receptor ligand opiate Remifentanil Family 10 24
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Serotonin re-uptake inhibitor Dibenzazepine Clomipramine Family 2 23
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Nuclear receptor subfamily 1 group I member 3 ligand piperazin... 3 82
Calmodulin Inhibitor Aprindine Family 1 4
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Histamine H1 receptor Ligand Antazoline Family 5 57
D(2) dopamine receptor Ligand Nomifensine Family 6 100
Motilin receptor Ligand GSK962040 Family 30 457
Tumor necrosis factor Inhibitor Pirfenidone Family 2 38
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Potassium voltage-gated channel subfamily A member 3 Ligand CP... 4 26
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 14 78
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 1,3,... 3 4
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
5-hydroxytryptamine receptor 6 Ligand [2-(3h-indol-1-yl)-ethyl... 2 7
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 8 32
Androgen receptor Ligand YM-175735 Family 30 129
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Aromatase Inhibitor 3-amino-4'-amino-trans-stilbene Family 5 47
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 10
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 2 9
Dipeptidyl peptidase 4 Inhibitor (3s,4r)-3-butyl-1-phenylpiper... 2 40
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Histamine H3 receptor Ligand (r)-1-(4-nitrophenethyl)-2-methyl... 16 38
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Sphingosine kinase 2 Inhibitor (r)-2-amino-3-(4-octylphenylami... 1 16
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 3 34
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 0
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 2 7
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 42
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 45
Acetylcholinesterase Inhibitor (3-hydroxy-2-methyl-phenyl)-tri... 4 25
Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-a... 1 15
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 1 2
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 5 5
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 4
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 7 27
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 1
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 6
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 2A ligand AGN-PC-075LXD family 4 4
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 5
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 0
Sigma non-opioid intracellular receptor 1 ligand 1-[4-[1-adama... 4 23
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 2 3
Peroxisome proliferator-activated receptor delta ligand (Z)-2-... 1 0
Sigma non-opioid intracellular receptor 1 ligand 1-[(3-nitroph... 4 2
5-hydroxytryptamine receptor 7 ligand 1-[2-(4-nitrophenyl)phen... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-[[4... 7 11
Substance-P receptor ligand (2R,3R)-2-benzhydryl-N-(2-iodophen... 2 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand 4-[(... 2 3
Histamine H3 receptor ligand 1-[4-[4-(pyrrolidin-1-ylmethyl)ph... 4 2
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-[2-... 3 1
Histamine H3 receptor ligand SureCN3052824 family 4 14
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 0
Potassium voltage-gated channel subfamily H member 2 and D(3) ... 3 0
Type-2 angiotensin II receptor ligand SureCN3515537 family 1 0
5-hydroxytryptamine receptor 2B and Prostaglandin G/H synthase... 1 16
Retinal dehydrogenase 1 and Nuclear receptor ROR-gamma ligand ... 3 13
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 4
D(4) dopamine receptor ligand 2-[4-[(3E)-3-ethoxyimino-3-pheny... 1 0
Lysosomal Pro-X carboxypeptidase and Glutamate receptor ionotr... 1 0
Squalene monooxygenase inhibitor 3-[[[(E)-6,6-dimethylhept-2-e... 1 0
Sigma non-opioid intracellular receptor 1 and Sodium-dependent... 2 1
Cholinesterase inhibitor 10-[[(1R,9aR)-2,3,4,6,7,8,9,9a-octahy... 1 0
Trypanothione reductase inhibitor 6-bromo-2-methyl-4-phenyl-3-... 2 3
Sodium-dependent dopamine transporter inhibitor AGN-PC-006XV1 ... 3 0
Potassium voltage-gated channel subfamily A member 5 and Inter... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 3 4
Monoglyceride lipase and Fatty-acid amide hydrolase 1 inhibito... 1 4
3,3,5,5-tetramethyl-N-phenyl-1,2,4,6,7,8-hexahydronaphthalen-2... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00286719 CHEMBL111896 Bioactive 1-phenyl-4-(3-phenylpropyl)piperazine
CFAMM00286730 DNC011038 Investigative Drug 1,6-bis(4-phenylpiperazin-1-yl)hexane
CFAMM00286729 DNC011039 Investigative Drug 1,6-bis(4-m-tolylpiperazin-1-yl)hexane

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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