CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3233
Family Name 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 2A Ligand 1,6-bis(4-(3-methoxyphenyl)piperazin-1-yl)hexane Family
No. of Seeds 9 No. of Other Members 28
Family Centroid CFAMM00286780 Functional Category Investigative Drug with Natural Product
Superfamily 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 2A Binder Superfamily 3
Class Class 1166

Cousin Family NamesSeedsMembers
Potassium voltage-gated channel subfamily H member 2 Ligand Do... 5 30
Acetylcholinesterase Inhibitor Edrophonium Family 7 40
Acetylcholinesterase Inhibitor Neostigmine Family 4 76
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
Cholesteryl ester transfer protein Inhibitor CP-800569 Family 5 81
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 3 67
Substance-P receptor Ligand Ezlopitant Family 10 207
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
Dp-b99 family 1 5
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
Peptidyl-prolyl cis-trans isomerase A Inhibitor 7-amino-4-meth... 4 59
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
Mineralocorticoid receptor and Androgen receptor Ligand AL-43 ... 79 235
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 20
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Carbonic anhydrase 2 Inhibitor 4-methoxyphenylsulfamide Family 2 27
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Cholesteryl ester transfer protein Inhibitor Tetrahydroquinoli... 3 8
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Fatty-acid amide hydrolase 1 Inhibitor Propan-2-one O-4-(hexyl... 12 4
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Fatty-acid amide hydrolase 1 Inhibitor Phenmedipham Family 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 9
Fatty-acid amide hydrolase 1 Inhibitor 4-nitrophenyl 4-benzylp... 5 35
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00G... 16 4
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 10
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 4 6
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 2
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 4 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 2
Mitogen-activated protein kinase 1 and Muscarinic acetylcholin... 1 1
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 8 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Estrogen receptor and Estrogen receptor beta ligand SureCN5681... 7 3
Survival motor neuron protein and DNA-(apurinic or apyrimidini... 1 5
Acetylcholinesterase inhibitor trimethyl-(2-methyl-3-propanoyl... 3 2
Acetylcholinesterase inhibitor AGN-PC-075N8G family 2 9
Sodium-dependent serotonin transporter inhibitor SureCN3890472... 2 0
Survival motor neuron protein and ATP-dependent DNA helicase Q... 1 4
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 2 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 9
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 11 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Histamine H3 receptor ligand 5-[4-[3-[(2R)-2-methylpyrrolidin-... 2 3
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 2 3
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 1
Translocator protein inhibitor [11C]DAA1106 family 15 2
Histamine H3 receptor ligand SureCN6109532 family 1 0
Cathepsin K inhibitor (1R,2R)-N-(cyanomethyl)-2-[4-(3-methoxyp... 2 1
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 10 1
Translocator protein inhibitor CHEMBL2332259 family 2 0
Angiotensin-converting enzyme inhibitor AGN-PC-076HUS family 2 3
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 1
5-hydroxytryptamine receptor 7 ligand 1-(2-methoxyphenyl)-4-[2... 6 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2
D(3) dopamine receptor and D(2) dopamine receptor ligand (5R)-... 2 0
Coagulation factor X and Cationic trypsin inhibitor 3-[(E)-3-[... 3 2
Delta-type opioid receptor and Kappa-type opioid receptor liga... 5 0
5-hydroxytryptamine receptor 1A ligand AGN-PC-0034EG family 5 2
5-hydroxytryptamine receptor 1A ligand (1R,2R)-2-[4-(2,3-dihyd... 2 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Substance-P receptor ligand CP 141938 family 1 0
5-hydroxytryptamine receptor 1A ligand AGN-PC-00FVK4 family 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 2
Sigma non-opioid intracellular receptor 1 ligand (5S)-5-[(4-hy... 1 5
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand Desac... 2 3
Melanin-concentrating hormone receptor 1 ligand SureCN6779516 ... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 1 0
Acetylcholinesterase and Cholinesterase inhibitor [3-hydroxy-5... 2 4
Kappa-type opioid receptor ligand AGN-PC-077Q4X family 1 1
Histamine H3 receptor ligand SureCN3057839 family 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 1 7
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 0
Prelamin-A/C and Nonstructural protein 1 inhibitor CHEMBL14536... 1 2
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 6
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 0
Leukotriene A-4 hydrolase inhibitor AGN-PC-087BON family 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand (5Z,8... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00286800 CHEMBL136148 Bioactive SureCN9605247
CFAMM00286793 CHEMBL129790 Bioactive AGN-PC-00G32K
CFAMM00286786 CHEMBL545721 Bioactive AGN-PC-07BZHB
CFAMM00286799 CHEMBL193861 Bioactive 1-phenyl-4-[[4-(1-propan-2-ylpiperidin-4-yl)oxyphenyl]methyl]piperazine
CFAMM00286792 CHEMBL542906 Bioactive AGN-PC-07BZHP
CFAMM00286802 CHEMBL1173143 Bioactive AGN-PC-00DDJP
CFAMM00286780 DNC011040 Investigative Drug 1,6-bis(4-(3-methoxyphenyl)piperazin-1-yl)hexane

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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