CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3235
Family Name 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine receptor 2C Ligand 6-chloro-n-(pyridin-3-yl)indoline-1-carboxamide Family
No. of Seeds 5 No. of Other Members 9
Family Centroid CFAMM00286863 Functional Category Investigative Drug
Superfamily 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine receptor 2C Ligand 6-chloro-n-(pyridin-3-yl)indoline-1-carboxamide Superfamily
Class Class 88

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Acetylcholinesterase Inhibitor Tacrine Family 12 515
D(2) dopamine receptor Ligand Sertindole Family 3 173
Histamine H1 receptor Ligand Triprolidine Family 19 316
Transient receptor potential cation channel subfamily V member... 15 158
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 6 66
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Amg 423 family 7 47
ABC294640 family 5 75
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 1,3-... 7 2
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... 2 16
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Urotensin-2 receptor Ligand Palosuran Family 4 4
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Transient receptor potential cation channel subfamily V member... 3 1
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 4
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 1 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Metabotropic glutamate receptor 5 ligand [(E)-(1,2-dicyclohexy... 1 4
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... 15 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Prostaglandin E synthase inhibitor AGN-PC-09QHBK family 3 1
Prostaglandin E synthase and Aldo-keto reductase family 1 memb... 3 12
C-X-C chemokine receptor type 3 ligand (6aR,9R)-N-phenyl-4-(2-... 5 0
Neuronal acetylcholine receptor subunit alpha-7 ligand 1-(4-me... 1 0
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Cholesteryl ester transfer protein inhibitor 1-[(1S)-1-(5-chlo... 1 4
Cytochrome P450 2C9 and Cytochrome P450 1A2 inhibitor SB 22128... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 10 1
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Sterol O-acyltransferase 1 inhibitor SureCN7073167 family 4 2
N-formyl peptide receptor 2 ligand 1-(1-methyl-3-oxo-5-propan-... 3 1
Reverse transcriptase/RNaseH inhibitor (4s)-6-chloro-4-cyclopr... 5 3
Nonstructural protein 1 and Cruzipain inhibitor CHEMBL1331578 ... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00286864 DNC011044 Investigative Drug N-(pyridin-3-yl)indoline-1-carboxamide
CFAMM00286863 DNC011042 Investigative Drug 6-chloro-N-(pyridin-3-yl)indoline-1-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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