CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3238
Family Name Cathepsin S Inhibitor 6-(3-(trifluoromethyl)phenyl)picolinonitrile Family
No. of Seeds 7 No. of Other Members 2
Family Centroid CFAMM00286882 Functional Category Investigative Drug
Superfamily Cathepsin S and Metabotropic glutamate receptor 5 Binder Superfamily
Class Class 2102

Cousin Family NamesSeedsMembers
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-(4-phenylb... 6 32
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 9 24
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 3
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Metabotropic glutamate receptor 5 Ligand 3-fluoro-5-(2-methylq... 3 2
Metabotropic glutamate receptor 5 Ligand 3-chloro-5-(2-methylq... 3 4
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SQ6 family 3 0
Lysosomal alpha-glucosidase inhibitor CHEMBL1575891 family 1 0
Potassium voltage-gated channel subfamily H member 2 ligand 1-... 1 0
Kinesin-like protein KIF11 inhibitor AGN-PC-077SFB family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00286877 CHEMBL1784609 Bioactive AGN-PC-0A9RFW
CFAMM00286876 CHEMBL1784608 Bioactive AGN-PC-07N6GM
CFAMM00286874 CHEMBL2089182 Bioactive 6-[2-(3-cyano-5-fluorophenyl)ethynyl]pyridine-2-carbonitrile
CFAMM00286881 CHEMBL2089179 Bioactive 3-[2-(6-ethylpyridin-2-yl)ethynyl]benzonitrile
CFAMM00286880 CHEMBL2089174 Bioactive 6-[2-(3-cyanophenyl)ethynyl]pyridine-2-carbonitrile
CFAMM00286882 DNC011063 Investigative Drug 6-(3-(trifluoromethyl)phenyl)picolinonitrile
CFAMM00286878 DNC014063 Investigative Drug 3-[(6-Methylpyridin-2-yl)ethynyl]benzonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543