CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3242
Family Name 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine receptor 2C Ligand Nelotanserin Family
No. of Seeds 50 No. of Other Members 36
Family Centroid CFAMM00286941 Functional Category Investigative Drug
Superfamily 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine receptor 2C Ligand Nelotanserin Superfamily
Class Class 1322

Cousin Family NamesSeedsMembers
Mitogen-activated protein kinase 12 Inhibitor ARRY-797 Family 13 41
Mitogen-activated protein kinase 12 Inhibitor Birb 796 Family 20 43
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 31
SB1518 family 7 103
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
D(2) dopamine receptor and D(3) dopamine receptor Ligand Benzy... 2 9
Transient receptor potential cation channel subfamily V member... 7 17
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 5 0
Transient receptor potential cation channel subfamily V member... 2 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 6
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 6 2
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Rho-associated protein kinase 2 inhibitor 1-ethyl-1-[(3-methox... 15 8
P2Y purinoceptor 1 inhibitor 1-(4-tert-butylphenyl)-3-[2-(2-pr... 4 14
Cell division cycle 7-related protein kinase inhibitor SureCN4... 1 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 25 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 0
Sodium channel protein type 4 subunit alpha ligand AGN-PC-006B... 3 2
Adenosine receptor A3 ligand 2-(4-methoxyphenyl)-3H-pyrazolo[1... 1 0


External ID

Functional Category

Molecule Name

CFAMM00286930 CHEMBL604586 Bioactive AGN-PC-00ERV9
CFAMM00286957 CHEMBL565322 Bioactive AGN-PC-07CQRF
CFAMM00286971 CHEMBL599828 Bioactive AGN-PC-00DJEN
CFAMM00286929 CHEMBL568109 Bioactive AGN-PC-07CQRU
CFAMM00286979 CHEMBL597152 Bioactive AGN-PC-00BY1P
CFAMM00286901 CHEMBL597983 Bioactive AGN-PC-00C6ID
CFAMM00286970 CHEMBL599194 Bioactive AGN-PC-006WAI
CFAMM00286935 CHEMBL585387 Bioactive AGN-PC-07CQR8
CFAMM00286949 CHEMBL610208 Bioactive AGN-PC-008XLU
CFAMM00286962 CHEMBL596975 Bioactive AGN-PC-03ZNM6
CFAMM00286978 CHEMBL603609 Bioactive AGN-PC-00FWEL
CFAMM00286942 CHEMBL567458 Bioactive AGN-PC-07CQSO
CFAMM00286906 CHEMBL605001 Bioactive AGN-PC-00EL6X
CFAMM00286968 CHEMBL599193 Bioactive SureCN5056055
CFAMM00286921 CHEMBL606622 Bioactive AGN-PC-00ERMH
CFAMM00286934 CHEMBL599226 Bioactive AGN-PC-00E2XB
CFAMM00286912 CHEMBL591223 Bioactive SureCN171483
CFAMM00286983 CHEMBL569475 Bioactive AGN-PC-00CYO5
CFAMM00286905 CHEMBL567877 Bioactive AGN-PC-07CQSF
CFAMM00286920 CHEMBL598171 Bioactive SureCN5063270
CFAMM00286933 CHEMBL599225 Bioactive SureCN5055980
CFAMM00286947 CHEMBL565525 Bioactive AGN-PC-07CQTE
CFAMM00286926 CHEMBL571917 Bioactive AGN-PC-07CQSY
CFAMM00286953 CHEMBL603078 Bioactive AGN-PC-00FEL3
CFAMM00286904 CHEMBL602064 Bioactive SureCN5055885
CFAMM00286918 CHEMBL598173 Bioactive AGN-PC-00DWRZ
CFAMM00286982 CHEMBL606178 Bioactive SureCN5055873
CFAMM00286959 CHEMBL583624 Bioactive AGN-PC-07CQRL
CFAMM00286939 CHEMBL602873 Bioactive AGN-PC-00AQXV
CFAMM00286952 CHEMBL596753 Bioactive AGN-PC-007M3G
CFAMM00286965 CHEMBL603061 Bioactive AGN-PC-00CWWZ
CFAMM00286903 CHEMBL604082 Bioactive AGN-PC-005YRL
CFAMM00286917 CHEMBL566383 Bioactive AGN-PC-00APZN
CFAMM00286931 CHEMBL601097 Bioactive AGN-PC-00B0HT
CFAMM00286972 CHEMBL596735 Bioactive SureCN5063239
CFAMM00286924 CHEMBL606191 Bioactive SureCN5061405
CFAMM00286938 CHEMBL602874 Bioactive SureCN5052896
CFAMM00286951 CHEMBL608425 Bioactive SureCN5052895
CFAMM00286964 CHEMBL596976 Bioactive AGN-PC-00CI0W
CFAMM00286915 CHEMBL598378 Bioactive AGN-PC-00G4EN
CFAMM00286941 DNC011100 Investigative Drug NELOTANSERIN

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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